Tags

Type your tag names separated by a space and hit enter

Serum levels of irisin in gestational diabetes mellitus during pregnancy and after delivery.
Cytokine. 2014 Feb; 65(2):153-8.C

Abstract

OBJECTIVE

Irisin has recently been introduced as a novel an exercise-inducible myokine which improves glucose metabolism in mice. However, regulation of circulating irisin in gestational diabetes mellitus (GDM) and in the peripartal period has not been assessed so far.

METHODS

Circulating irisin was quantified in 74 GDM patients and in 74 healthy, pregnant, gestational age-matched controls. In a subset of these patients (44 GDM, 41 controls), postpartum follow-up data were also available. In a second study population of 40 healthy women with singleton pregnancies undergoing elective Cesarean section, irisin was assessed in maternal serum before and within 24h after delivery, as well as in umbilical cord blood and in placental tissue.

RESULTS

In the first study population, median [interquartile range] irisin levels were significantly higher in GDM patients as compared to controls after delivery (previous GDM: 446.3 [146.9]μg/l; controls: 378.0 [111.4]μg/l) but not during pregnancy (GDM: 482.1 [132.1]μg/l; controls: 466.6 [178.0]μg/l). Interestingly, fasting insulin (FI) was independently and positively associated with serum irisin in multivariate analysis during pregnancy. In agreement with these findings, relative changes (ratio) of FI independently and positively predicted relative changes of irisin (ratio) in the second study population.

CONCLUSIONS

The myokine irisin is independently associated with FI in pregnancy. The physiological significance of these findings needs to be assessed in future experiments.

Authors+Show Affiliations

University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany. Electronic address: thomas.ebert@medizin.uni-leipzig.de.University of Leipzig, Department of Obstetrics, 04103 Leipzig, Germany.University of Leipzig, Department of Obstetrics, 04103 Leipzig, Germany.University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany.University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany.University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany.University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany.University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany.University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany.Centre for Trophoblast Research, Medical School, Wayne State University, Detroit, MI, USA.University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany.University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany.University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24355429

Citation

Ebert, Thomas, et al. "Serum Levels of Irisin in Gestational Diabetes Mellitus During Pregnancy and After Delivery." Cytokine, vol. 65, no. 2, 2014, pp. 153-8.
Ebert T, Stepan H, Schrey S, et al. Serum levels of irisin in gestational diabetes mellitus during pregnancy and after delivery. Cytokine. 2014;65(2):153-8.
Ebert, T., Stepan, H., Schrey, S., Kralisch, S., Hindricks, J., Hopf, L., Platz, M., Lossner, U., Jessnitzer, B., Drewlo, S., Blüher, M., Stumvoll, M., & Fasshauer, M. (2014). Serum levels of irisin in gestational diabetes mellitus during pregnancy and after delivery. Cytokine, 65(2), 153-8. https://doi.org/10.1016/j.cyto.2013.11.009
Ebert T, et al. Serum Levels of Irisin in Gestational Diabetes Mellitus During Pregnancy and After Delivery. Cytokine. 2014;65(2):153-8. PubMed PMID: 24355429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum levels of irisin in gestational diabetes mellitus during pregnancy and after delivery. AU - Ebert,Thomas, AU - Stepan,Holger, AU - Schrey,Susanne, AU - Kralisch,Susan, AU - Hindricks,Janka, AU - Hopf,Lisa, AU - Platz,Martin, AU - Lossner,Ulrike, AU - Jessnitzer,Beate, AU - Drewlo,Sascha, AU - Blüher,Matthias, AU - Stumvoll,Michael, AU - Fasshauer,Mathias, Y1 - 2013/12/16/ PY - 2013/06/27/received PY - 2013/09/16/revised PY - 2013/11/24/accepted PY - 2013/12/21/entrez PY - 2013/12/21/pubmed PY - 2014/9/12/medline KW - AFABP KW - BMI KW - C reactive protein KW - CRP KW - ELISA KW - FFA KW - FG KW - FGF-21 KW - FI KW - GDM KW - Gestational diabetes mellitus KW - HDL KW - HOMA-IR KW - HbA1c KW - Irisin KW - LDL KW - Myokine KW - OGTT KW - Pregnancy KW - T2DM KW - TG KW - WHR KW - adipocyte fatty acid-binding protein KW - body mass-index KW - enzyme-linked immunosorbent assay KW - fasting glucose KW - fasting insulin KW - fibroblast growth factor-21 KW - free fatty acids KW - gestational diabetes mellitus KW - glycosylated hemoglobin A1c KW - high density lipoprotein KW - homeostasis model assessment of insulin resistance KW - low density lipoprotein KW - oral glucose tolerance test KW - triglycerides KW - type 2 diabetes mellitus KW - waist to hip-ratio SP - 153 EP - 8 JF - Cytokine JO - Cytokine VL - 65 IS - 2 N2 - OBJECTIVE: Irisin has recently been introduced as a novel an exercise-inducible myokine which improves glucose metabolism in mice. However, regulation of circulating irisin in gestational diabetes mellitus (GDM) and in the peripartal period has not been assessed so far. METHODS: Circulating irisin was quantified in 74 GDM patients and in 74 healthy, pregnant, gestational age-matched controls. In a subset of these patients (44 GDM, 41 controls), postpartum follow-up data were also available. In a second study population of 40 healthy women with singleton pregnancies undergoing elective Cesarean section, irisin was assessed in maternal serum before and within 24h after delivery, as well as in umbilical cord blood and in placental tissue. RESULTS: In the first study population, median [interquartile range] irisin levels were significantly higher in GDM patients as compared to controls after delivery (previous GDM: 446.3 [146.9]μg/l; controls: 378.0 [111.4]μg/l) but not during pregnancy (GDM: 482.1 [132.1]μg/l; controls: 466.6 [178.0]μg/l). Interestingly, fasting insulin (FI) was independently and positively associated with serum irisin in multivariate analysis during pregnancy. In agreement with these findings, relative changes (ratio) of FI independently and positively predicted relative changes of irisin (ratio) in the second study population. CONCLUSIONS: The myokine irisin is independently associated with FI in pregnancy. The physiological significance of these findings needs to be assessed in future experiments. SN - 1096-0023 UR - https://www.unboundmedicine.com/medline/citation/24355429/Serum_levels_of_irisin_in_gestational_diabetes_mellitus_during_pregnancy_and_after_delivery_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1043-4666(13)00759-X DB - PRIME DP - Unbound Medicine ER -