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Hypovitaminosis D and executive dysfunction in older adults with memory complaint: a memory clinic-based study.

Abstract

BACKGROUND

Hypovitaminosis D is associated with executive dysfunction as a whole. The purpose of this cross-sectional study was to determine whether lower vitamin D levels were associated with mental flexibility, information updating, or cognitive and motor inhibition among older adults.

METHODS

One hundred Caucasian older community dwellers with memory complaint (mean, 71.02 ± 0.74 years; 52.0% female) were divided into 3 groups according to serum 25-hydroxyvitamin D (25-OHD) concentration (deficiency <25 nmol/l, insufficiency 25-50 nmol/l, sufficiency >50 nmol/l). Executive functions were assessed with error rates by executing the Trail Making Test-B (TMT-B) for mental flexibility, the N-Back Test for information updating, the Stroop Interference Test for cognitive inhibition, and the Go/No-Go score for motor inhibition. Age, gender, BMI, education level, number of morbidities, depressive symptoms, Mini-Mental State Examination score, calcemia, estimated glomerular filtration rate and season tested were considered as potential confounders.

RESULTS

Compared to participants with vitamin D insufficiency and sufficiency, those with vitamin D deficiency had a poorer TMT-B performance (p = 0.019 and p = 0.017, respectively) but similar N-Back (p = 0.175), Stroop (p = 0.135) and Go/No-Go (p = 0.224) scores. Cognitive performance did not differ between participants with insufficient and sufficient vitamin D levels. Vitamin D deficiency was associated with poorer performance on TMT-B (adjusted β = 1.48, p = 0.011), but not on N-Back (p = 0.665), Stroop (p = 0.817) or Go/No-Go (p = 0.971).

CONCLUSION

Vitamin D deficiency was associated with poorer mental flexibility among older community dwellers with memory complaint.

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  • Authors+Show Affiliations

    ,

    Division of Geriatric Medicine and Memory Clinic, Department of Neuroscience, Angers University Hospital, UPRES EA 4638, Angers, France.

    , ,

    Source

    MeSH

    Aged
    Cognition Disorders
    Executive Function
    Female
    Humans
    Male
    Memory Disorders
    Neuropsychological Tests
    Vitamin D
    Vitamin D Deficiency

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24356580

    Citation

    Annweiler, Cédric, et al. "Hypovitaminosis D and Executive Dysfunction in Older Adults With Memory Complaint: a Memory Clinic-based Study." Dementia and Geriatric Cognitive Disorders, vol. 37, no. 5-6, 2014, pp. 286-93.
    Annweiler C, Maby E, Meyerber M, et al. Hypovitaminosis D and executive dysfunction in older adults with memory complaint: a memory clinic-based study. Dement Geriatr Cogn Disord. 2014;37(5-6):286-93.
    Annweiler, C., Maby, E., Meyerber, M., & Beauchet, O. (2014). Hypovitaminosis D and executive dysfunction in older adults with memory complaint: a memory clinic-based study. Dementia and Geriatric Cognitive Disorders, 37(5-6), pp. 286-93. doi:10.1159/000356483.
    Annweiler C, et al. Hypovitaminosis D and Executive Dysfunction in Older Adults With Memory Complaint: a Memory Clinic-based Study. Dement Geriatr Cogn Disord. 2014;37(5-6):286-93. PubMed PMID: 24356580.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Hypovitaminosis D and executive dysfunction in older adults with memory complaint: a memory clinic-based study. AU - Annweiler,Cédric, AU - Maby,Elodie, AU - Meyerber,Marine, AU - Beauchet,Olivier, Y1 - 2013/12/17/ PY - 2013/09/27/accepted PY - 2013/12/21/entrez PY - 2013/12/21/pubmed PY - 2015/2/3/medline SP - 286 EP - 93 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 37 IS - 5-6 N2 - BACKGROUND: Hypovitaminosis D is associated with executive dysfunction as a whole. The purpose of this cross-sectional study was to determine whether lower vitamin D levels were associated with mental flexibility, information updating, or cognitive and motor inhibition among older adults. METHODS: One hundred Caucasian older community dwellers with memory complaint (mean, 71.02 ± 0.74 years; 52.0% female) were divided into 3 groups according to serum 25-hydroxyvitamin D (25-OHD) concentration (deficiency <25 nmol/l, insufficiency 25-50 nmol/l, sufficiency >50 nmol/l). Executive functions were assessed with error rates by executing the Trail Making Test-B (TMT-B) for mental flexibility, the N-Back Test for information updating, the Stroop Interference Test for cognitive inhibition, and the Go/No-Go score for motor inhibition. Age, gender, BMI, education level, number of morbidities, depressive symptoms, Mini-Mental State Examination score, calcemia, estimated glomerular filtration rate and season tested were considered as potential confounders. RESULTS: Compared to participants with vitamin D insufficiency and sufficiency, those with vitamin D deficiency had a poorer TMT-B performance (p = 0.019 and p = 0.017, respectively) but similar N-Back (p = 0.175), Stroop (p = 0.135) and Go/No-Go (p = 0.224) scores. Cognitive performance did not differ between participants with insufficient and sufficient vitamin D levels. Vitamin D deficiency was associated with poorer performance on TMT-B (adjusted β = 1.48, p = 0.011), but not on N-Back (p = 0.665), Stroop (p = 0.817) or Go/No-Go (p = 0.971). CONCLUSION: Vitamin D deficiency was associated with poorer mental flexibility among older community dwellers with memory complaint. SN - 1421-9824 UR - https://www.unboundmedicine.com/medline/citation/24356580/Hypovitaminosis_D_and_executive_dysfunction_in_older_adults_with_memory_complaint:_a_memory_clinic_based_study_ L2 - https://www.karger.com?DOI=10.1159/000356483 DB - PRIME DP - Unbound Medicine ER -