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Hypovitaminosis D and executive dysfunction in older adults with memory complaint: a memory clinic-based study.
Dement Geriatr Cogn Disord 2014; 37(5-6):286-93DG

Abstract

BACKGROUND

Hypovitaminosis D is associated with executive dysfunction as a whole. The purpose of this cross-sectional study was to determine whether lower vitamin D levels were associated with mental flexibility, information updating, or cognitive and motor inhibition among older adults.

METHODS

One hundred Caucasian older community dwellers with memory complaint (mean, 71.02 ± 0.74 years; 52.0% female) were divided into 3 groups according to serum 25-hydroxyvitamin D (25-OHD) concentration (deficiency <25 nmol/l, insufficiency 25-50 nmol/l, sufficiency >50 nmol/l). Executive functions were assessed with error rates by executing the Trail Making Test-B (TMT-B) for mental flexibility, the N-Back Test for information updating, the Stroop Interference Test for cognitive inhibition, and the Go/No-Go score for motor inhibition. Age, gender, BMI, education level, number of morbidities, depressive symptoms, Mini-Mental State Examination score, calcemia, estimated glomerular filtration rate and season tested were considered as potential confounders.

RESULTS

Compared to participants with vitamin D insufficiency and sufficiency, those with vitamin D deficiency had a poorer TMT-B performance (p = 0.019 and p = 0.017, respectively) but similar N-Back (p = 0.175), Stroop (p = 0.135) and Go/No-Go (p = 0.224) scores. Cognitive performance did not differ between participants with insufficient and sufficient vitamin D levels. Vitamin D deficiency was associated with poorer performance on TMT-B (adjusted β = 1.48, p = 0.011), but not on N-Back (p = 0.665), Stroop (p = 0.817) or Go/No-Go (p = 0.971).

CONCLUSION

Vitamin D deficiency was associated with poorer mental flexibility among older community dwellers with memory complaint.

Authors+Show Affiliations

Division of Geriatric Medicine and Memory Clinic, Department of Neuroscience, Angers University Hospital, UPRES EA 4638, Angers, France.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24356580

Citation

Annweiler, Cédric, et al. "Hypovitaminosis D and Executive Dysfunction in Older Adults With Memory Complaint: a Memory Clinic-based Study." Dementia and Geriatric Cognitive Disorders, vol. 37, no. 5-6, 2014, pp. 286-93.
Annweiler C, Maby E, Meyerber M, et al. Hypovitaminosis D and executive dysfunction in older adults with memory complaint: a memory clinic-based study. Dement Geriatr Cogn Disord. 2014;37(5-6):286-93.
Annweiler, C., Maby, E., Meyerber, M., & Beauchet, O. (2014). Hypovitaminosis D and executive dysfunction in older adults with memory complaint: a memory clinic-based study. Dementia and Geriatric Cognitive Disorders, 37(5-6), pp. 286-93. doi:10.1159/000356483.
Annweiler C, et al. Hypovitaminosis D and Executive Dysfunction in Older Adults With Memory Complaint: a Memory Clinic-based Study. Dement Geriatr Cogn Disord. 2014;37(5-6):286-93. PubMed PMID: 24356580.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypovitaminosis D and executive dysfunction in older adults with memory complaint: a memory clinic-based study. AU - Annweiler,Cédric, AU - Maby,Elodie, AU - Meyerber,Marine, AU - Beauchet,Olivier, Y1 - 2013/12/17/ PY - 2013/09/27/accepted PY - 2013/12/21/entrez PY - 2013/12/21/pubmed PY - 2015/2/3/medline SP - 286 EP - 93 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 37 IS - 5-6 N2 - BACKGROUND: Hypovitaminosis D is associated with executive dysfunction as a whole. The purpose of this cross-sectional study was to determine whether lower vitamin D levels were associated with mental flexibility, information updating, or cognitive and motor inhibition among older adults. METHODS: One hundred Caucasian older community dwellers with memory complaint (mean, 71.02 ± 0.74 years; 52.0% female) were divided into 3 groups according to serum 25-hydroxyvitamin D (25-OHD) concentration (deficiency <25 nmol/l, insufficiency 25-50 nmol/l, sufficiency >50 nmol/l). Executive functions were assessed with error rates by executing the Trail Making Test-B (TMT-B) for mental flexibility, the N-Back Test for information updating, the Stroop Interference Test for cognitive inhibition, and the Go/No-Go score for motor inhibition. Age, gender, BMI, education level, number of morbidities, depressive symptoms, Mini-Mental State Examination score, calcemia, estimated glomerular filtration rate and season tested were considered as potential confounders. RESULTS: Compared to participants with vitamin D insufficiency and sufficiency, those with vitamin D deficiency had a poorer TMT-B performance (p = 0.019 and p = 0.017, respectively) but similar N-Back (p = 0.175), Stroop (p = 0.135) and Go/No-Go (p = 0.224) scores. Cognitive performance did not differ between participants with insufficient and sufficient vitamin D levels. Vitamin D deficiency was associated with poorer performance on TMT-B (adjusted β = 1.48, p = 0.011), but not on N-Back (p = 0.665), Stroop (p = 0.817) or Go/No-Go (p = 0.971). CONCLUSION: Vitamin D deficiency was associated with poorer mental flexibility among older community dwellers with memory complaint. SN - 1421-9824 UR - https://www.unboundmedicine.com/medline/citation/24356580/Hypovitaminosis_D_and_executive_dysfunction_in_older_adults_with_memory_complaint:_a_memory_clinic_based_study_ L2 - https://www.karger.com?DOI=10.1159/000356483 DB - PRIME DP - Unbound Medicine ER -