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Xanthones from Swertia mussotii and their α-glycosidase inhibitory activities.
Planta Med. 2014 Feb; 80(2-3):201-8.PM

Abstract

Two new xanthones, 1,8-dihydroxy-3-methoxyxanthone 7-O-[α-L-rhamnopyranosyl(1 → 2)-β-D-glucopyranoside] (1) and 1,8- dihydroxy-3-methoxyxanthone 7-O-[α-L-rhamnopyranosyl(1 → 3)-α-L-rhamno-pyranosyl (1 → 2)-β-D-xylopyranoside] (2), together with 26 known xanthones (3-28), were isolated from the aqueous ethanol extract of the traditional Chinese herb Swertia mussotii. Their structures were elucidated via spectroscopic analyses including 2D NMR. The inhibition of α-glucosidase by the isolated xanthones was evaluated by an in vitro high-throughput screening assay. Our results indicated that 1,3,5,8-tetrahydroxyxanthone is the best inhibitor with an IC50 value of 5.33 ± 0.09 µM, while the O-glycosylated xanthones were poor α-glycosidase inhibitors.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China.

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China.

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China.

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China.

State key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China.

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China.

MeSH

Glycoside HydrolasesNuclear Magnetic Resonance, BiomolecularPlant ExtractsSoftwareSwertiaXanthones

Pub Type(s)

Journal Article

Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24356906

Citation

Luo, Cui-Ting, et al. "Xanthones From Swertia Mussotii and Their Α-glycosidase Inhibitory Activities." Planta Medica, vol. 80, no. 2-3, 2014, pp. 201-8.

Luo CT, Zheng HH, Mao SS, et al. Xanthones from Swertia mussotii and their α-glycosidase inhibitory activities. Planta Med. 2014;80(2-3):201-8.

Luo, C. T., Zheng, H. H., Mao, S. S., Yang, M. X., Luo, C., & Chen, H. (2014). Xanthones from Swertia mussotii and their α-glycosidase inhibitory activities. Planta Medica, 80(2-3), 201-8. https://doi.org/10.1055/s-0033-1360173

Luo CT, et al. Xanthones From Swertia Mussotii and Their Α-glycosidase Inhibitory Activities. Planta Med. 2014;80(2-3):201-8. PubMed PMID: 24356906.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Xanthones from Swertia mussotii and their α-glycosidase inhibitory activities. AU - Luo,Cui-Ting, AU - Zheng,Huan-huan, AU - Mao,Shuang-Shuang, AU - Yang,Mao-xun, AU - Luo,Cheng, AU - Chen,Heru, Y1 - 2013/12/19/ PY - 2013/12/21/entrez PY - 2013/12/21/pubmed PY - 2014/11/8/medline SP - 201 EP - 8 JF - Planta medica JO - Planta Med VL - 80 IS - 2-3 N2 - Two new xanthones, 1,8-dihydroxy-3-methoxyxanthone 7-O-[α-L-rhamnopyranosyl(1 → 2)-β-D-glucopyranoside] (1) and 1,8- dihydroxy-3-methoxyxanthone 7-O-[α-L-rhamnopyranosyl(1 → 3)-α-L-rhamno-pyranosyl (1 → 2)-β-D-xylopyranoside] (2), together with 26 known xanthones (3-28), were isolated from the aqueous ethanol extract of the traditional Chinese herb Swertia mussotii. Their structures were elucidated via spectroscopic analyses including 2D NMR. The inhibition of α-glucosidase by the isolated xanthones was evaluated by an in vitro high-throughput screening assay. Our results indicated that 1,3,5,8-tetrahydroxyxanthone is the best inhibitor with an IC50 value of 5.33 ± 0.09 µM, while the O-glycosylated xanthones were poor α-glycosidase inhibitors. SN - 1439-0221 UR - https://www.unboundmedicine.com/medline/citation/24356906/Xanthones_from_Swertia_mussotii_and_their_α_glycosidase_inhibitory_activities_ DB - PRIME DP - Unbound Medicine ER -