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[Impact of vitamin D in neurological diseases and neurorehabilitation: from dementia to multiple sclerosis. Part I: the role of vitamin D in the prevention and treatment of multiple sclerosis].

Abstract

The world-wide incidence of vitamin D deficiency is high, independently of age. Multiple sclerosis is a chronic disorder, occuring in those who possess or are exposed to a combination of genetic and environmental risk factors. One of the environmental factors associated with the development is vitamin D. Vitamin D is an immunomodulatory agent, its role is verified in many of autoimmune diseases. Vitamin D inhibits IL-6, IL-17 and IL-23 secretions which are crucial in Th1 and Th17 differentiation and also decreases proinflammatorical cytokine production. Moreover it enhances the immunosuppressive IL-10 cytokine secretion and inhibits the T-reg cell development. These cytokines and cells are essential for the pathomechanism of multiple sclerosis. Data have shown, that the vitamin D levels above 100 nmol/l (40 ng/ml) is essential for the prevention of multiple sclerosis. Below this level the vitamin D supplementation is reasonable. In pregnancy, the vitamin D deficiency at the last two semester increases the risk for the multiple sclerosis of the infant. The optimal vitamin D level for multiple sclerosis patients is 100-150 nmol/l (40-60 ng/ml). There is no consensus for the role of vitamin D in multiple sclerosis yet, but until the achieving this, the diagnosis and the treatment of the vitamin D deficiency is crucial for scelrosis multiplex patients and in cases of elevated risk. Data shows, that in patient with multiple sclerosis the normal vitamin D level is suboptimal, however the exact role of vitamin D and doses must be clarified by interventional studies.

Authors+Show Affiliations

Budai Irgalmasrendi Kórház (1023 Budapest, Frankel Leó út 54.) és Pálmai-Med Egészségügyi Központ. vitamindspeer@gmail.com

Source

Ideggyogyaszati szemle 66:9-10 2013 Sep 30 pg 293-303

MeSH

Dementia
Dietary Supplements
Drug Administration Schedule
Female
Humans
Hypercalcemia
Immunologic Factors
Multiple Sclerosis
Pregnancy
Pregnancy Complications
Sunlight
Vitamin D
Vitamin D Deficiency
Vitamins

Pub Type(s)

English Abstract
Journal Article
Review

Language

hun

PubMed ID

24358684

Citation

Speer, Gábor. "[Impact of Vitamin D in Neurological Diseases and Neurorehabilitation: From Dementia to Multiple Sclerosis. Part I: the Role of Vitamin D in the Prevention and Treatment of Multiple Sclerosis]." Ideggyogyaszati Szemle, vol. 66, no. 9-10, 2013, pp. 293-303.
Speer G. [Impact of vitamin D in neurological diseases and neurorehabilitation: from dementia to multiple sclerosis. Part I: the role of vitamin D in the prevention and treatment of multiple sclerosis]. Ideggyogy Sz. 2013;66(9-10):293-303.
Speer, G. (2013). [Impact of vitamin D in neurological diseases and neurorehabilitation: from dementia to multiple sclerosis. Part I: the role of vitamin D in the prevention and treatment of multiple sclerosis]. Ideggyogyaszati Szemle, 66(9-10), pp. 293-303.
Speer G. [Impact of Vitamin D in Neurological Diseases and Neurorehabilitation: From Dementia to Multiple Sclerosis. Part I: the Role of Vitamin D in the Prevention and Treatment of Multiple Sclerosis]. Ideggyogy Sz. 2013 Sep 30;66(9-10):293-303. PubMed PMID: 24358684.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Impact of vitamin D in neurological diseases and neurorehabilitation: from dementia to multiple sclerosis. Part I: the role of vitamin D in the prevention and treatment of multiple sclerosis]. A1 - Speer,Gábor, PY - 2013/12/24/entrez PY - 2013/12/24/pubmed PY - 2014/1/25/medline SP - 293 EP - 303 JF - Ideggyogyaszati szemle JO - Ideggyogy Sz VL - 66 IS - 9-10 N2 - The world-wide incidence of vitamin D deficiency is high, independently of age. Multiple sclerosis is a chronic disorder, occuring in those who possess or are exposed to a combination of genetic and environmental risk factors. One of the environmental factors associated with the development is vitamin D. Vitamin D is an immunomodulatory agent, its role is verified in many of autoimmune diseases. Vitamin D inhibits IL-6, IL-17 and IL-23 secretions which are crucial in Th1 and Th17 differentiation and also decreases proinflammatorical cytokine production. Moreover it enhances the immunosuppressive IL-10 cytokine secretion and inhibits the T-reg cell development. These cytokines and cells are essential for the pathomechanism of multiple sclerosis. Data have shown, that the vitamin D levels above 100 nmol/l (40 ng/ml) is essential for the prevention of multiple sclerosis. Below this level the vitamin D supplementation is reasonable. In pregnancy, the vitamin D deficiency at the last two semester increases the risk for the multiple sclerosis of the infant. The optimal vitamin D level for multiple sclerosis patients is 100-150 nmol/l (40-60 ng/ml). There is no consensus for the role of vitamin D in multiple sclerosis yet, but until the achieving this, the diagnosis and the treatment of the vitamin D deficiency is crucial for scelrosis multiplex patients and in cases of elevated risk. Data shows, that in patient with multiple sclerosis the normal vitamin D level is suboptimal, however the exact role of vitamin D and doses must be clarified by interventional studies. SN - 0019-1442 UR - https://www.unboundmedicine.com/medline/citation/24358684/[Impact_of_vitamin_D_in_neurological_diseases_and_neurorehabilitation:_from_dementia_to_multiple_sclerosis__Part_I:_the_role_of_vitamin_D_in_the_prevention_and_treatment_of_multiple_sclerosis]_ L2 - http://www.diseaseinfosearch.org/result/4969 DB - PRIME DP - Unbound Medicine ER -