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[Absorption and pharmacokinetics of radix rehmanniae in rats].
Yao Xue Xue Bao. 2013 Sep; 48(9):1464-70.YX

Abstract

In this paper, absorption and pharmacokinetic study of Radix Rehmanniae was studied by liquid chromatography coupled with mass spectrometry method after oral administration to rats. By comparing the chromatograms of ultraviolet, full scan, extracted ion and selective reaction monitoring (SRM) of standard solution, Radix Rehmanniae, blank plasma and rat plasma post drug administration, catalpol and ajugol were found to be the main compounds absorbed from Radix Rehmanniae. Plasma concentrations of aucubin, dihydrocatalpol, rehmannioside A (or rehmannioside B/ melittoside) and rehmannioside D were very low. Quantitative method for catalpol and aucubin and semi-quantitative method for other compounds in rat plasma were established. The pharmacokinetic study of those absorbed components was conducted after oral administration of 6 g x kg(-1) Radix Rehmanniae water extract to rats. Cmax, t(1/2) and AUC(0-infinity) of catalpol and ajugol were (2349.05 +/- 1438.34) and (104.25 +/- 82.05) ng x mL(-1), (0.86 +/- 0.32) and (0.96 +/- 0.37) h, (4407.58 +/- 2734.89) and (226.66 +/- 188.38) ng x h x mL(-1), respectively. tmax was at 1.00 h for catalpol and ajugol. Both catalpol and ajugol were absorbed and excreted rapidly.

Authors+Show Affiliations

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

MeSH

Administration, OralAnimalsArea Under CurveDrugs, Chinese HerbalFemaleIridoid GlucosidesIridoid GlycosidesMaleMolecular StructurePlant RootsPlants, MedicinalPyransRatsRats, Sprague-DawleyRehmannia

Pub Type(s)

Journal Article

Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

24358782

Citation

Zhong, Jie, et al. "[Absorption and Pharmacokinetics of Radix Rehmanniae in Rats]." Yao Xue Xue Bao = Acta Pharmaceutica Sinica, vol. 48, no. 9, 2013, pp. 1464-70.

Zhong J, Tan ZD, Wang TM, et al. [Absorption and pharmacokinetics of radix rehmanniae in rats]. Yao Xue Xue Bao. 2013;48(9):1464-70.

Zhong, J., Tan, Z. D., Wang, T. M., Shi, R., & Ma, Y. M. (2013). [Absorption and pharmacokinetics of radix rehmanniae in rats]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 48(9), 1464-70.

Zhong J, et al. [Absorption and Pharmacokinetics of Radix Rehmanniae in Rats]. Yao Xue Xue Bao. 2013;48(9):1464-70. PubMed PMID: 24358782.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - [Absorption and pharmacokinetics of radix rehmanniae in rats]. AU - Zhong,Jie, AU - Tan,Zhao-dan, AU - Wang,Tian-ming, AU - Shi,Rong, AU - Ma,Yue-ming, PY - 2013/12/24/entrez PY - 2013/12/24/pubmed PY - 2016/2/3/medline SP - 1464 EP - 70 JF - Yao xue xue bao = Acta pharmaceutica Sinica JO - Yao Xue Xue Bao VL - 48 IS - 9 N2 - In this paper, absorption and pharmacokinetic study of Radix Rehmanniae was studied by liquid chromatography coupled with mass spectrometry method after oral administration to rats. By comparing the chromatograms of ultraviolet, full scan, extracted ion and selective reaction monitoring (SRM) of standard solution, Radix Rehmanniae, blank plasma and rat plasma post drug administration, catalpol and ajugol were found to be the main compounds absorbed from Radix Rehmanniae. Plasma concentrations of aucubin, dihydrocatalpol, rehmannioside A (or rehmannioside B/ melittoside) and rehmannioside D were very low. Quantitative method for catalpol and aucubin and semi-quantitative method for other compounds in rat plasma were established. The pharmacokinetic study of those absorbed components was conducted after oral administration of 6 g x kg(-1) Radix Rehmanniae water extract to rats. Cmax, t(1/2) and AUC(0-infinity) of catalpol and ajugol were (2349.05 +/- 1438.34) and (104.25 +/- 82.05) ng x mL(-1), (0.86 +/- 0.32) and (0.96 +/- 0.37) h, (4407.58 +/- 2734.89) and (226.66 +/- 188.38) ng x h x mL(-1), respectively. tmax was at 1.00 h for catalpol and ajugol. Both catalpol and ajugol were absorbed and excreted rapidly. SN - 0513-4870 UR - https://www.unboundmedicine.com/medline/citation/24358782/[Absorption_and_pharmacokinetics_of_radix_rehmanniae_in_rats]_ DB - PRIME DP - Unbound Medicine ER -