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Intake of total omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid and risk of coronary heart disease in the Spanish EPIC cohort study.
Nutr Metab Cardiovasc Dis 2014; 24(3):321-7NM

Abstract

BACKGROUND AND AIMS

The evidence about the benefits of omega-3 fatty acid intake on coronary heart disease (CHD) is not consistent. We thus aimed to assess the relation between dietary intake of total omega-3 fatty acids (from plant and marine foods) and marine polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on the risk of CHD in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC).

METHODS AND RESULTS

The analysis included 41,091 men and women aged 20-69 years, recruited from 1992 to 1996 and followed-up until December 2004. Omega-3 fatty acid intake was estimated from a validated dietary questionnaire. Only participants with definite incident CHD event were considered as cases. Cox regression models were used to assess the association between the intake of total omega-3 fatty acids, EPA or DHA and CHD. A total of 609 participants (79% men) had a definite CHD event. Mean intakes of total omega-3 fatty acids, EPA and DHA were very similar in the cases and in the cohort, both in men and women. In the multivariate adjusted model, omega-3 fatty acids, EPA and DHA were not related to incident CHD in either men or women. The hazard ratios (HR) for omega-3 were 1.23 in men (95% CI 0.94-15.9, p = 0.20); and 0.77 in women (95% CI 0.46-1.30, p = 0.76).

CONCLUSION

In the Spanish EPIC cohort, with a relatively high intake of fish, no association was found between EPA, DHA and total omega-3 fatty acid intake and risk of CHD.

Authors+Show Affiliations

Public Health Department of Gipuzkoa, Government of the Basque Country, and BioDonostia Research Institute, San Sebastian, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain. Electronic address: epicss-san@ej-gv.es.Primary Care Research Unit OSIs of Gipuzkoa, Basque Health Service-Osakidetza, San Sebastian, Spain; Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Spain.Public Health Department of Gipuzkoa, Government of the Basque Country, and BioDonostia Research Institute, San Sebastian, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain.Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain.Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain; Navarre Public Health Institute, Pamplona, Spain.Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain; Andalusian School of Public Health, Granada, Spain.Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain; Department of Sociosanitary Science, University of Murcia School of Medicine, Murcia, Spain.Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain.Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain; Andalusian School of Public Health, Granada, Spain.Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain; Andalusian School of Public Health, Granada, Spain.Public Health Department of Gipuzkoa, Government of the Basque Country, and BioDonostia Research Institute, San Sebastian, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain.Public Health Department of Gipuzkoa, Government of the Basque Country, and BioDonostia Research Institute, San Sebastian, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain.Public Health Department of Gipuzkoa, Government of the Basque Country, and BioDonostia Research Institute, San Sebastian, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain.Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain; Navarre Public Health Institute, Pamplona, Spain.Public Health and Health Planning Directorate, Oviedo, Spain.Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain; Navarre Public Health Institute, Pamplona, Spain.Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Barcelona, Spain.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24360762

Citation

Amiano, P, et al. "Intake of Total Omega-3 Fatty Acids, Eicosapentaenoic Acid and Docosahexaenoic Acid and Risk of Coronary Heart Disease in the Spanish EPIC Cohort Study." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 24, no. 3, 2014, pp. 321-7.
Amiano P, Machón M, Dorronsoro M, et al. Intake of total omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid and risk of coronary heart disease in the Spanish EPIC cohort study. Nutr Metab Cardiovasc Dis. 2014;24(3):321-7.
Amiano, P., Machón, M., Dorronsoro, M., Chirlaque, M. D., Barricarte, A., Sánchez, M. J., ... González, C. A. (2014). Intake of total omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid and risk of coronary heart disease in the Spanish EPIC cohort study. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 24(3), pp. 321-7. doi:10.1016/j.numecd.2013.08.011.
Amiano P, et al. Intake of Total Omega-3 Fatty Acids, Eicosapentaenoic Acid and Docosahexaenoic Acid and Risk of Coronary Heart Disease in the Spanish EPIC Cohort Study. Nutr Metab Cardiovasc Dis. 2014;24(3):321-7. PubMed PMID: 24360762.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of total omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid and risk of coronary heart disease in the Spanish EPIC cohort study. AU - Amiano,P, AU - Machón,M, AU - Dorronsoro,M, AU - Chirlaque,M Dolores, AU - Barricarte,A, AU - Sánchez,M-J, AU - Navarro,C, AU - Huerta,J M, AU - Molina-Montes,E, AU - Sánchez-Cantalejo,E, AU - Urtizberea,M, AU - Arriola,L, AU - Larrañaga,N, AU - Ardanaz,E, AU - Quirós,J R, AU - Moreno-Iribas,C, AU - González,C A, Y1 - 2013/12/20/ PY - 2013/02/15/received PY - 2013/07/19/revised PY - 2013/08/19/accepted PY - 2013/12/24/entrez PY - 2013/12/24/pubmed PY - 2014/11/15/medline KW - Cohort studies KW - Coronary heart disease KW - DHA KW - EPA KW - Omega-3 fatty acids SP - 321 EP - 7 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 24 IS - 3 N2 - BACKGROUND AND AIMS: The evidence about the benefits of omega-3 fatty acid intake on coronary heart disease (CHD) is not consistent. We thus aimed to assess the relation between dietary intake of total omega-3 fatty acids (from plant and marine foods) and marine polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on the risk of CHD in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC). METHODS AND RESULTS: The analysis included 41,091 men and women aged 20-69 years, recruited from 1992 to 1996 and followed-up until December 2004. Omega-3 fatty acid intake was estimated from a validated dietary questionnaire. Only participants with definite incident CHD event were considered as cases. Cox regression models were used to assess the association between the intake of total omega-3 fatty acids, EPA or DHA and CHD. A total of 609 participants (79% men) had a definite CHD event. Mean intakes of total omega-3 fatty acids, EPA and DHA were very similar in the cases and in the cohort, both in men and women. In the multivariate adjusted model, omega-3 fatty acids, EPA and DHA were not related to incident CHD in either men or women. The hazard ratios (HR) for omega-3 were 1.23 in men (95% CI 0.94-15.9, p = 0.20); and 0.77 in women (95% CI 0.46-1.30, p = 0.76). CONCLUSION: In the Spanish EPIC cohort, with a relatively high intake of fish, no association was found between EPA, DHA and total omega-3 fatty acid intake and risk of CHD. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/24360762/Intake_of_total_omega_3_fatty_acids_eicosapentaenoic_acid_and_docosahexaenoic_acid_and_risk_of_coronary_heart_disease_in_the_Spanish_EPIC_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(13)00203-2 DB - PRIME DP - Unbound Medicine ER -