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Obesity is associated with increased relative risk of diffuse large B-cell lymphoma: a meta-analysis of observational studies.

Abstract

BACKGROUND

The relation between body mass index (BMI) and incidence of diffuse large B-cell lymphoma (DLBCL) has been suggested, but no systematic review has been undertaken.

MATERIAL AND METHODS

We performed a literature search through December 2012. Meta-analyses were performed to quantify the relative risk (RR) of DLBCL incidence in overweight and obese persons compared with normal weight individuals using the random-effects model. Subset analyses were performed according to study design, sex, and geographic region. Overweight was defined as a BMI 25 to 29.9 kg/m(2), and obesity was defined as a BMI of 30 kg/m(2). Meta-regression, using an unrestricted maximum likelihood model, was performed to evaluate the linear association between BMI and odds of DLBCL.

RESULTS

Our study included 6 case-control and 10 cohort studies. The RR of DLBCL in overweight individuals was 1.14 (95% confidence interval [CI], 1.04-1.24; P = .004), and in obese individuals, RR was 1.29 (95% CI, 1.16-1.43; P < .001). The RR of DLBCL in overweight men and women was 1.22 and 1.27, respectively. In overweight individuals, both prospective and case-control studies showed an RR of 1.13. The RR of DLBCL in obese men and women was 1.40 and 1.34, respectively. In obese individuals, the RR in prospective studies was 1.25 and in case-control studies it was 1.33. Meta-regression analysis showed a 14% increase in DLBCL incidence for each 10 kg/m(2) increase in BMI.

CONCLUSION

An increased BMI is associated with higher RR of DLBCL regardless of sex. Also, there seems to be a linear association between BMI and DLBCL incidence.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Hematologic Malignancies, Dana Farber Cancer Institute, Boston, MA. Electronic address: jorgej_castillo@dfci.harvard.edu.

    ,

    Division of Hematology and Oncology, Rhode Island Hospital, Providence, RI.

    ,

    Division of Hematology and Oncology, Rhode Island Hospital, Providence, RI.

    ,

    Department of Medicine, Rhode Island Hospital, Providence, RI.

    ,

    Division of Hematology and Oncology, Moffitt Cancer Center and Research Institute, Tampa, FL.

    Service of Endocrinology, Prima CARE, Fall River, MA.

    Source

    MeSH

    Case-Control Studies
    Cohort Studies
    Female
    Humans
    Lymphoma, Large B-Cell, Diffuse
    Male
    Obesity
    Observational Studies as Topic
    Overweight
    Regression Analysis
    Risk Factors

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Systematic Review

    Language

    eng

    PubMed ID

    24360912

    Citation

    Castillo, Jorge J., et al. "Obesity Is Associated With Increased Relative Risk of Diffuse Large B-cell Lymphoma: a Meta-analysis of Observational Studies." Clinical Lymphoma, Myeloma & Leukemia, vol. 14, no. 2, 2014, pp. 122-30.
    Castillo JJ, Ingham RR, Reagan JL, et al. Obesity is associated with increased relative risk of diffuse large B-cell lymphoma: a meta-analysis of observational studies. Clin Lymphoma Myeloma Leuk. 2014;14(2):122-30.
    Castillo, J. J., Ingham, R. R., Reagan, J. L., Furman, M., Dalia, S., & Mitri, J. (2014). Obesity is associated with increased relative risk of diffuse large B-cell lymphoma: a meta-analysis of observational studies. Clinical Lymphoma, Myeloma & Leukemia, 14(2), pp. 122-30. doi:10.1016/j.clml.2013.10.005.
    Castillo JJ, et al. Obesity Is Associated With Increased Relative Risk of Diffuse Large B-cell Lymphoma: a Meta-analysis of Observational Studies. Clin Lymphoma Myeloma Leuk. 2014;14(2):122-30. PubMed PMID: 24360912.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Obesity is associated with increased relative risk of diffuse large B-cell lymphoma: a meta-analysis of observational studies. AU - Castillo,Jorge J, AU - Ingham,Randall R, AU - Reagan,John L, AU - Furman,Michael, AU - Dalia,Samir, AU - Mitri,Joanna, Y1 - 2013/11/14/ PY - 2013/05/09/received PY - 2013/10/01/revised PY - 2013/10/21/accepted PY - 2013/12/24/entrez PY - 2013/12/24/pubmed PY - 2014/12/15/medline KW - Body mass index KW - Epidemiology KW - Lymphoma KW - Meta-analysis KW - Obesity SP - 122 EP - 30 JF - Clinical lymphoma, myeloma & leukemia JO - Clin Lymphoma Myeloma Leuk VL - 14 IS - 2 N2 - BACKGROUND: The relation between body mass index (BMI) and incidence of diffuse large B-cell lymphoma (DLBCL) has been suggested, but no systematic review has been undertaken. MATERIAL AND METHODS: We performed a literature search through December 2012. Meta-analyses were performed to quantify the relative risk (RR) of DLBCL incidence in overweight and obese persons compared with normal weight individuals using the random-effects model. Subset analyses were performed according to study design, sex, and geographic region. Overweight was defined as a BMI 25 to 29.9 kg/m(2), and obesity was defined as a BMI of 30 kg/m(2). Meta-regression, using an unrestricted maximum likelihood model, was performed to evaluate the linear association between BMI and odds of DLBCL. RESULTS: Our study included 6 case-control and 10 cohort studies. The RR of DLBCL in overweight individuals was 1.14 (95% confidence interval [CI], 1.04-1.24; P = .004), and in obese individuals, RR was 1.29 (95% CI, 1.16-1.43; P < .001). The RR of DLBCL in overweight men and women was 1.22 and 1.27, respectively. In overweight individuals, both prospective and case-control studies showed an RR of 1.13. The RR of DLBCL in obese men and women was 1.40 and 1.34, respectively. In obese individuals, the RR in prospective studies was 1.25 and in case-control studies it was 1.33. Meta-regression analysis showed a 14% increase in DLBCL incidence for each 10 kg/m(2) increase in BMI. CONCLUSION: An increased BMI is associated with higher RR of DLBCL regardless of sex. Also, there seems to be a linear association between BMI and DLBCL incidence. SN - 2152-2669 UR - https://www.unboundmedicine.com/medline/citation/24360912/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S2152-2650(13)00463-1 DB - PRIME DP - Unbound Medicine ER -