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Airflow obstruction and left ventricular filling pressure in suspected chronic obstructive pulmonary disease.
Respir Physiol Neurobiol. 2014 Feb 01; 192:85-9.RP

Abstract

Left ventricular (LV) filling impairment is present in patients with chronic obstructive pulmonary disease (COPD). Airflow obstruction is related to reduced LV end-diastolic volume, stroke volume, and cardiac output. The ratio of peak early diastolic filling velocity of the mitral inflow to peak early diastolic velocity of the mitral annulus (E/e'), an echocardiographic parameter, can be applied as a surrogate marker of LV filling pressures. Forty-seven individuals with suspected COPD underwent pulmonary function tests and echocardiography. The ratio of forced expiratory volume in 1s to forced vital capacity (FEV1/FVC) and the E/e' ratio were determined. Multivariate linear regression analysis showed that the FEV1/FVC ratio (β=0.01; 95% confidence interval, 0.001-0.019; p=0.036) independently predicted the log transformed E/e' ratio. An increase of FEV1/FVC ratio (in percentage) by 1 unit was associated with an increase of the E/e' ratio multiplied by 1.01. Airflow obstruction inversely predicts LV filling pressure in suspected COPD cases.

Authors+Show Affiliations

Department of Chest Medicine, En Chu Kong Hospital, Taiwan.Department of Chest Medicine, En Chu Kong Hospital, Taiwan.Department of Laboratory Medicine, En Chu Kong Hospital, Taiwan.Department of Cardiology, En Chu Kong Hospital, Taiwan.Department of Chest Medicine, En Chu Kong Hospital, Taiwan.Department of Chest Medicine, En Chu Kong Hospital, Taiwan.Department of Cardiology, En Chu Kong Hospital, Taiwan. Electronic address: yuehjuhtw@yahoo.com.tw.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24361463

Citation

Yu, Yung-Huey, et al. "Airflow Obstruction and Left Ventricular Filling Pressure in Suspected Chronic Obstructive Pulmonary Disease." Respiratory Physiology & Neurobiology, vol. 192, 2014, pp. 85-9.
Yu YH, Chen MZ, Wen LL, et al. Airflow obstruction and left ventricular filling pressure in suspected chronic obstructive pulmonary disease. Respir Physiol Neurobiol. 2014;192:85-9.
Yu, Y. H., Chen, M. Z., Wen, L. L., Chu, C. C., Chiang, C. T., Chen, C. H., & Lin, Y. J. (2014). Airflow obstruction and left ventricular filling pressure in suspected chronic obstructive pulmonary disease. Respiratory Physiology & Neurobiology, 192, 85-9. https://doi.org/10.1016/j.resp.2013.12.008
Yu YH, et al. Airflow Obstruction and Left Ventricular Filling Pressure in Suspected Chronic Obstructive Pulmonary Disease. Respir Physiol Neurobiol. 2014 Feb 1;192:85-9. PubMed PMID: 24361463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Airflow obstruction and left ventricular filling pressure in suspected chronic obstructive pulmonary disease. AU - Yu,Yung-Huey, AU - Chen,Ming-Zen, AU - Wen,Li-Li, AU - Chu,Ching-Chi, AU - Chiang,Chih-Teng, AU - Chen,Chung-Hua, AU - Lin,Yueh-Juh, Y1 - 2013/12/19/ PY - 2013/09/23/received PY - 2013/11/14/revised PY - 2013/12/10/accepted PY - 2013/12/24/entrez PY - 2013/12/24/pubmed PY - 2014/9/24/medline KW - A KW - Airflow obstruction KW - COPD KW - E KW - E/A KW - E/e′ KW - Echocardiography KW - FEV1 KW - FEV1/FVC KW - FVC KW - GOLD KW - Global Initiative for Chronic Obstructive Lung Disease KW - LV KW - LVEF KW - Left ventricular filling pressure KW - SpO2 KW - arterial oxygen saturation by pulse oximetry KW - chronic obstructive pulmonary disease KW - e′ KW - forced expiratory volume in 1s KW - forced vital capacity KW - left ventricular KW - left ventricular ejection fraction KW - lnE/e′ KW - peak early diastolic filling velocities of the mitral inflow KW - peak early diastolic velocity of the septal mitral annulus KW - peak late diastolic filling velocities of the mitral inflow KW - ratio of early to late peak diastolic filling velocities of the mitral inflow KW - ratio of forced expiratory volume in 1s to forced vital capacity KW - the log transformed ratio of peak early diastolic filling velocity of the mitral inflow to peak early diastolic velocity of the mitral annulus KW - the ratio of peak early diastolic filling velocity of the mitral inflow to peak early diastolic velocity of the mitral annulus SP - 85 EP - 9 JF - Respiratory physiology & neurobiology JO - Respir Physiol Neurobiol VL - 192 N2 - Left ventricular (LV) filling impairment is present in patients with chronic obstructive pulmonary disease (COPD). Airflow obstruction is related to reduced LV end-diastolic volume, stroke volume, and cardiac output. The ratio of peak early diastolic filling velocity of the mitral inflow to peak early diastolic velocity of the mitral annulus (E/e'), an echocardiographic parameter, can be applied as a surrogate marker of LV filling pressures. Forty-seven individuals with suspected COPD underwent pulmonary function tests and echocardiography. The ratio of forced expiratory volume in 1s to forced vital capacity (FEV1/FVC) and the E/e' ratio were determined. Multivariate linear regression analysis showed that the FEV1/FVC ratio (β=0.01; 95% confidence interval, 0.001-0.019; p=0.036) independently predicted the log transformed E/e' ratio. An increase of FEV1/FVC ratio (in percentage) by 1 unit was associated with an increase of the E/e' ratio multiplied by 1.01. Airflow obstruction inversely predicts LV filling pressure in suspected COPD cases. SN - 1878-1519 UR - https://www.unboundmedicine.com/medline/citation/24361463/Airflow_obstruction_and_left_ventricular_filling_pressure_in_suspected_chronic_obstructive_pulmonary_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1569-9048(13)00395-9 DB - PRIME DP - Unbound Medicine ER -