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Dermatological disorders in chronic kidney disease with and without maintenance hemodialysis.
JNMA J Nepal Med Assoc 2013 Apr-Jun; 52(190):365-71JJ

Abstract

INTRODUCTION

Dermatological disorders are common complications of CKD affecting all most all patients. Present study aimed to evaluate these disorders in CKD with and without Maintenance Hemodialysis and their association with age, sex, severity and duration of CKD and dialysis.

METHODS

It is a cross-sectional comparative study. Eighty-three patients with established CKD, without MHD (n=35) and with MHD (n= 48), were examined for dermatological disorders.

RESULTS

The mean age of patients were 46±15.6 years with male to female ratio of 1.18:1. Among CKD without MHD, six patients were in stage 4 and 29 patients were in stage 5 with estimated GFR (24.4±3.9 and 5.6±2.9) ml/1.73m2/min respectively by MDRD equation. CKD without and with MHD had similar age, sex, blood urea, hemoglobin. Dermatological disorders were found in 100% CKD patients with pallor 76 (91.5%), xerosis 63 (75.9%), pigmentary changes 54 (65%), pruritus 50 (60.2%), skin infection 40 (48.2%), vascular changes 14 (16.8%), mucosal changes 56 (67.5%), hair changes 49 (59%), non -specific nail changes 68 (81.9%) and specific nail changes 12 (14.4%). Specific 8 (22.8%) vs 4 (8.3%), p<0.03 and non- specific 32 (91.4%) vs 36 (75%), p<0.05 nail changes and hair abnormalities 26 (74.3%) vs. 23 (47.9%), p<0.01 were significantly lower in MHD patients.

CONCLUSIONS

Dermatological disorders were present in all CKD patients with significantly lower nail and hair changes in MHD. A further longitudinal study is necessary to find out pathophysiology and effect of treatment in these disorders.

Authors+Show Affiliations

Department of Dermatology, Shree Birendra Hospital, Kathmandu, Nepal.Department of Nephrology, National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal.Department of Dermatology, National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

24362662

Citation

Shah, Aparna, et al. "Dermatological Disorders in Chronic Kidney Disease With and Without Maintenance Hemodialysis." JNMA; Journal of the Nepal Medical Association, vol. 52, no. 190, 2013, pp. 365-71.
Shah A, Hada R, Kayastha BM. Dermatological disorders in chronic kidney disease with and without maintenance hemodialysis. JNMA J Nepal Med Assoc. 2013;52(190):365-71.
Shah, A., Hada, R., & Kayastha, B. M. (2013). Dermatological disorders in chronic kidney disease with and without maintenance hemodialysis. JNMA; Journal of the Nepal Medical Association, 52(190), pp. 365-71.
Shah A, Hada R, Kayastha BM. Dermatological Disorders in Chronic Kidney Disease With and Without Maintenance Hemodialysis. JNMA J Nepal Med Assoc. 2013;52(190):365-71. PubMed PMID: 24362662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dermatological disorders in chronic kidney disease with and without maintenance hemodialysis. AU - Shah,Aparna, AU - Hada,Rajani, AU - Kayastha,Bhasker Mahan Mehar, PY - 2013/12/24/entrez PY - 2013/12/24/pubmed PY - 2014/7/18/medline SP - 365 EP - 71 JF - JNMA; journal of the Nepal Medical Association JO - JNMA J Nepal Med Assoc VL - 52 IS - 190 N2 - INTRODUCTION: Dermatological disorders are common complications of CKD affecting all most all patients. Present study aimed to evaluate these disorders in CKD with and without Maintenance Hemodialysis and their association with age, sex, severity and duration of CKD and dialysis. METHODS: It is a cross-sectional comparative study. Eighty-three patients with established CKD, without MHD (n=35) and with MHD (n= 48), were examined for dermatological disorders. RESULTS: The mean age of patients were 46±15.6 years with male to female ratio of 1.18:1. Among CKD without MHD, six patients were in stage 4 and 29 patients were in stage 5 with estimated GFR (24.4±3.9 and 5.6±2.9) ml/1.73m2/min respectively by MDRD equation. CKD without and with MHD had similar age, sex, blood urea, hemoglobin. Dermatological disorders were found in 100% CKD patients with pallor 76 (91.5%), xerosis 63 (75.9%), pigmentary changes 54 (65%), pruritus 50 (60.2%), skin infection 40 (48.2%), vascular changes 14 (16.8%), mucosal changes 56 (67.5%), hair changes 49 (59%), non -specific nail changes 68 (81.9%) and specific nail changes 12 (14.4%). Specific 8 (22.8%) vs 4 (8.3%), p<0.03 and non- specific 32 (91.4%) vs 36 (75%), p<0.05 nail changes and hair abnormalities 26 (74.3%) vs. 23 (47.9%), p<0.01 were significantly lower in MHD patients. CONCLUSIONS: Dermatological disorders were present in all CKD patients with significantly lower nail and hair changes in MHD. A further longitudinal study is necessary to find out pathophysiology and effect of treatment in these disorders. SN - 0028-2715 UR - https://www.unboundmedicine.com/medline/citation/24362662/Dermatological_disorders_in_chronic_kidney_disease_with_and_without_maintenance_hemodialysis_ L2 - http://www.diseaseinfosearch.org/result/3996 DB - PRIME DP - Unbound Medicine ER -