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Investigation of relationships among gastroesophageal reflux disease subtypes using narrow band imaging magnifying endoscopy.
World J Gastroenterol. 2013 Dec 07; 19(45):8391-7.WJ

Abstract

AIM

To investigate the relationships among subtypes of gastroesophageal reflux disease (GERD) using narrow band imaging (NBI) magnifying endoscopy.

METHODS

A reflux disease questionnaire was used to screen 120 patients representing the three subtypes of GERD (n = 40 for each subtypes): nonerosive reflux disease (NERD), reflux esophagitis (RE) and Barrett's esophagus (BE). NBI magnifying endoscopic procedure was performed on the patients as well as on 40 healthy controls. The demographic and clinical characteristics, and NBI magnifying endoscopic features, were recorded and compared among the groups. Targeted biopsy and histopathological examination were conducted if there were any abnormalities. SPSS 18.0 software was used for all statistical analysis.

RESULTS

Compared with healthy controls, a significantly higher proportion of GERD patients had increased number of intrapapillary capillary loops (IPCLs) (78.3% vs 20%, P < 0.05), presence of microerosions (41.7% vs 0%, P < 0.05), and a non-round pit pattern below the squamocolumnar junction (88.3% vs 30%, P < 0.05). The maximum (228 ± 4.8 vs 144 ± 4.7, P < 0.05), minimum (171 ± 3.8 vs 103 ± 4.4, P < 0.05), and average (199 ± 3.9 vs 119 ± 3.9, P < 0.05) numbers of IPCLs/field were also significantly greater in GERD patients. However, comparison among groups of the three subtypes showed no significant differences or any linear trend, except that microerosions were present in 60% of the RE patients, but in only 35% and 30% of the NERD and BE patients, respectively (P < 0.05).

CONCLUSION

Patients with GERD, irrespective of subtype, have similar micro changes in the distal esophagus. The three forms of the disease are probably independent of each other.

Authors+Show Affiliations

Jing Lv, Dong Liu, Shi-Yang Ma, Jun Zhang, Department of Gastroenterology, the Second Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an 710004, Shaanxi Province, China.Jing Lv, Dong Liu, Shi-Yang Ma, Jun Zhang, Department of Gastroenterology, the Second Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an 710004, Shaanxi Province, China.Jing Lv, Dong Liu, Shi-Yang Ma, Jun Zhang, Department of Gastroenterology, the Second Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an 710004, Shaanxi Province, China.Jing Lv, Dong Liu, Shi-Yang Ma, Jun Zhang, Department of Gastroenterology, the Second Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an 710004, Shaanxi Province, China.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24363532

Citation

Lv, Jing, et al. "Investigation of Relationships Among Gastroesophageal Reflux Disease Subtypes Using Narrow Band Imaging Magnifying Endoscopy." World Journal of Gastroenterology, vol. 19, no. 45, 2013, pp. 8391-7.
Lv J, Liu D, Ma SY, et al. Investigation of relationships among gastroesophageal reflux disease subtypes using narrow band imaging magnifying endoscopy. World J Gastroenterol. 2013;19(45):8391-7.
Lv, J., Liu, D., Ma, S. Y., & Zhang, J. (2013). Investigation of relationships among gastroesophageal reflux disease subtypes using narrow band imaging magnifying endoscopy. World Journal of Gastroenterology, 19(45), 8391-7. https://doi.org/10.3748/wjg.v19.i45.8391
Lv J, et al. Investigation of Relationships Among Gastroesophageal Reflux Disease Subtypes Using Narrow Band Imaging Magnifying Endoscopy. World J Gastroenterol. 2013 Dec 7;19(45):8391-7. PubMed PMID: 24363532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation of relationships among gastroesophageal reflux disease subtypes using narrow band imaging magnifying endoscopy. AU - Lv,Jing, AU - Liu,Dong, AU - Ma,Shi-Yang, AU - Zhang,Jun, PY - 2013/06/19/received PY - 2013/09/24/revised PY - 2013/10/19/accepted PY - 2013/12/24/entrez PY - 2013/12/24/pubmed PY - 2014/6/13/medline KW - Gastroesophageal reflux KW - Gastroesophageal reflux disease KW - Intrapapillary capillary loops KW - Magnifying endoscopy KW - Narrow band imaging SP - 8391 EP - 7 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 19 IS - 45 N2 - AIM: To investigate the relationships among subtypes of gastroesophageal reflux disease (GERD) using narrow band imaging (NBI) magnifying endoscopy. METHODS: A reflux disease questionnaire was used to screen 120 patients representing the three subtypes of GERD (n = 40 for each subtypes): nonerosive reflux disease (NERD), reflux esophagitis (RE) and Barrett's esophagus (BE). NBI magnifying endoscopic procedure was performed on the patients as well as on 40 healthy controls. The demographic and clinical characteristics, and NBI magnifying endoscopic features, were recorded and compared among the groups. Targeted biopsy and histopathological examination were conducted if there were any abnormalities. SPSS 18.0 software was used for all statistical analysis. RESULTS: Compared with healthy controls, a significantly higher proportion of GERD patients had increased number of intrapapillary capillary loops (IPCLs) (78.3% vs 20%, P < 0.05), presence of microerosions (41.7% vs 0%, P < 0.05), and a non-round pit pattern below the squamocolumnar junction (88.3% vs 30%, P < 0.05). The maximum (228 ± 4.8 vs 144 ± 4.7, P < 0.05), minimum (171 ± 3.8 vs 103 ± 4.4, P < 0.05), and average (199 ± 3.9 vs 119 ± 3.9, P < 0.05) numbers of IPCLs/field were also significantly greater in GERD patients. However, comparison among groups of the three subtypes showed no significant differences or any linear trend, except that microerosions were present in 60% of the RE patients, but in only 35% and 30% of the NERD and BE patients, respectively (P < 0.05). CONCLUSION: Patients with GERD, irrespective of subtype, have similar micro changes in the distal esophagus. The three forms of the disease are probably independent of each other. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/24363532/Investigation_of_relationships_among_gastroesophageal_reflux_disease_subtypes_using_narrow_band_imaging_magnifying_endoscopy_ L2 - http://www.wjgnet.com/1007-9327/full/v19/i45/8391.htm DB - PRIME DP - Unbound Medicine ER -