Tags

Type your tag names separated by a space and hit enter

Humanin: a possible linkage between Alzheimer's disease and type 2 diabetes.
CNS Neurol Disord Drug Targets 2014; 13(3):543-52CN

Abstract

The prevalence of Alzheimer's disease (AD) is higher among type 2 diabetes mellitus (T2DM) patients. In T2DM patients, the progression of AD is more rapid. Furthermore, several pathophysiological pathways are common to AD and T2DM. Humanin is a recently introduced, mitochondrial-derived peptide with neuroprotective effects. Humanin can alter the mechanisms involved in AD and T2DM pathogenesis. Insulin resistance as well as oxidative stress has been shown to be associated with increased amyloid deposition in brain neurons and islet beta cells. Moreover, advanced glycation end products and lipid metabolism disorders are common pathways of oxidative stress and low-grade systemic inflammation in AD and T2DM. These common pathways may explain AD and T2DM pathogenesis and suggest common treatments for both diseases. Treatments for T2DM and AD attempt to slow cognitive decline, and recent investigations have focused on agents that may alter pathways common to AD and T2DM pathogenesis. Non-steroidal antiinflammatory drugs, such as interleukin-1 antagonists and statins, are possible drug candidates for both AD and T2DM.

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableHamidreza Mahboobi, Hormozgan University of Medical Sciences (HUMS), Bandar Abbas, Hormozgan, Iran. hamidrezamahboobi@yahoo.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24365186

Citation

Mahboobi, Hamidreza, et al. "Humanin: a Possible Linkage Between Alzheimer's Disease and Type 2 Diabetes." CNS & Neurological Disorders Drug Targets, vol. 13, no. 3, 2014, pp. 543-52.
Mahboobi H, Golmirzaei J, Gan SH, et al. Humanin: a possible linkage between Alzheimer's disease and type 2 diabetes. CNS Neurol Disord Drug Targets. 2014;13(3):543-52.
Mahboobi, H., Golmirzaei, J., Gan, S. H., Jalalian, M., & Kamal, M. A. (2014). Humanin: a possible linkage between Alzheimer's disease and type 2 diabetes. CNS & Neurological Disorders Drug Targets, 13(3), pp. 543-52.
Mahboobi H, et al. Humanin: a Possible Linkage Between Alzheimer's Disease and Type 2 Diabetes. CNS Neurol Disord Drug Targets. 2014;13(3):543-52. PubMed PMID: 24365186.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Humanin: a possible linkage between Alzheimer's disease and type 2 diabetes. AU - Mahboobi,Hamidreza, AU - Golmirzaei,Javad, AU - Gan,Siew H, AU - Jalalian,Mehrdad, AU - Kamal,Mohammad A, PY - 2013/05/28/received PY - 2013/10/09/revised PY - 2013/10/09/accepted PY - 2013/12/25/entrez PY - 2013/12/25/pubmed PY - 2015/1/8/medline SP - 543 EP - 52 JF - CNS & neurological disorders drug targets JO - CNS Neurol Disord Drug Targets VL - 13 IS - 3 N2 - The prevalence of Alzheimer's disease (AD) is higher among type 2 diabetes mellitus (T2DM) patients. In T2DM patients, the progression of AD is more rapid. Furthermore, several pathophysiological pathways are common to AD and T2DM. Humanin is a recently introduced, mitochondrial-derived peptide with neuroprotective effects. Humanin can alter the mechanisms involved in AD and T2DM pathogenesis. Insulin resistance as well as oxidative stress has been shown to be associated with increased amyloid deposition in brain neurons and islet beta cells. Moreover, advanced glycation end products and lipid metabolism disorders are common pathways of oxidative stress and low-grade systemic inflammation in AD and T2DM. These common pathways may explain AD and T2DM pathogenesis and suggest common treatments for both diseases. Treatments for T2DM and AD attempt to slow cognitive decline, and recent investigations have focused on agents that may alter pathways common to AD and T2DM pathogenesis. Non-steroidal antiinflammatory drugs, such as interleukin-1 antagonists and statins, are possible drug candidates for both AD and T2DM. SN - 1996-3181 UR - https://www.unboundmedicine.com/medline/citation/24365186/Humanin:_a_possible_linkage_between_Alzheimer's_disease_and_type_2_diabetes_ L2 - http://www.eurekaselect.com/119106/article DB - PRIME DP - Unbound Medicine ER -