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The effects of short-term fish oil supplementation on pulmonary function and airway inflammation following a high-fat meal.
Eur J Appl Physiol. 2014 Apr; 114(4):675-82.EJ

Abstract

INTRODUCTION

Many environmental and dietary influences can cause immune cells to produce biological mediators that increase airway inflammation. A high-fat meal (HFM) is one stimulus that increases airway inflammation in healthy individuals. Supplementation with omega-3 fatty acids can reduce inflammation systemically and may be beneficial to the airways.

PURPOSE

To determine if omega-3 fatty acid supplementation via fish oil would mitigate the airway inflammatory response induced by a single HFM.

METHODS

Seventeen non-asthmatic men (22 ± 2 years.) were supplemented with 3,000 mg × day(-1) fish oil or a placebo for 3 weeks. Fractional exhaled nitric oxide (FENO; a marker of airway inflammation), impulse oscillometry (a measure of respiratory impedance), pulmonary function, and triglycerides were measured prior to and 2 h following a HFM.

RESULTS

Following a HFM, triglycerides increased in both fish oil and placebo groups compared to pre-HFM (~59 and ~49 %, respectively, p < 0.05). The percent increase in FENO was greater in the placebo group compared to the fish oil group (25.7 ± 16.7 vs. -1.99 ± 10.5 %, respectively, p < 0.05). A significant correlation was observed between blood triglycerides and FENO in the placebo group (r = 0.61; p < 0.05), but not the fish oil group (p = 0.21).

CONCLUSION

A single HFM increases airway inflammation and omega-3 fatty acid supplementation via fish oil protects against HFM associated changes in airway health.

Authors+Show Affiliations

Department of Kinesiology, Kansas State University, 1A Natatorium, Manhattan, KS, 66502, USA, cade@ksu.edu.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

24368552

Citation

Ade, Carl J., et al. "The Effects of Short-term Fish Oil Supplementation On Pulmonary Function and Airway Inflammation Following a High-fat Meal." European Journal of Applied Physiology, vol. 114, no. 4, 2014, pp. 675-82.
Ade CJ, Rosenkranz SK, Harms CA. The effects of short-term fish oil supplementation on pulmonary function and airway inflammation following a high-fat meal. Eur J Appl Physiol. 2014;114(4):675-82.
Ade, C. J., Rosenkranz, S. K., & Harms, C. A. (2014). The effects of short-term fish oil supplementation on pulmonary function and airway inflammation following a high-fat meal. European Journal of Applied Physiology, 114(4), 675-82. https://doi.org/10.1007/s00421-013-2792-7
Ade CJ, Rosenkranz SK, Harms CA. The Effects of Short-term Fish Oil Supplementation On Pulmonary Function and Airway Inflammation Following a High-fat Meal. Eur J Appl Physiol. 2014;114(4):675-82. PubMed PMID: 24368552.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of short-term fish oil supplementation on pulmonary function and airway inflammation following a high-fat meal. AU - Ade,Carl J, AU - Rosenkranz,S K, AU - Harms,C A, Y1 - 2013/12/25/ PY - 2013/07/25/received PY - 2013/12/05/accepted PY - 2013/12/26/entrez PY - 2013/12/26/pubmed PY - 2014/11/8/medline SP - 675 EP - 82 JF - European journal of applied physiology JO - Eur. J. Appl. Physiol. VL - 114 IS - 4 N2 - INTRODUCTION: Many environmental and dietary influences can cause immune cells to produce biological mediators that increase airway inflammation. A high-fat meal (HFM) is one stimulus that increases airway inflammation in healthy individuals. Supplementation with omega-3 fatty acids can reduce inflammation systemically and may be beneficial to the airways. PURPOSE: To determine if omega-3 fatty acid supplementation via fish oil would mitigate the airway inflammatory response induced by a single HFM. METHODS: Seventeen non-asthmatic men (22 ± 2 years.) were supplemented with 3,000 mg × day(-1) fish oil or a placebo for 3 weeks. Fractional exhaled nitric oxide (FENO; a marker of airway inflammation), impulse oscillometry (a measure of respiratory impedance), pulmonary function, and triglycerides were measured prior to and 2 h following a HFM. RESULTS: Following a HFM, triglycerides increased in both fish oil and placebo groups compared to pre-HFM (~59 and ~49 %, respectively, p < 0.05). The percent increase in FENO was greater in the placebo group compared to the fish oil group (25.7 ± 16.7 vs. -1.99 ± 10.5 %, respectively, p < 0.05). A significant correlation was observed between blood triglycerides and FENO in the placebo group (r = 0.61; p < 0.05), but not the fish oil group (p = 0.21). CONCLUSION: A single HFM increases airway inflammation and omega-3 fatty acid supplementation via fish oil protects against HFM associated changes in airway health. SN - 1439-6327 UR - https://www.unboundmedicine.com/medline/citation/24368552/The_effects_of_short_term_fish_oil_supplementation_on_pulmonary_function_and_airway_inflammation_following_a_high_fat_meal_ L2 - https://dx.doi.org/10.1007/s00421-013-2792-7 DB - PRIME DP - Unbound Medicine ER -