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Total antioxidant capacity of the diet and risk of age-related cataract: a population-based prospective cohort of women.

Abstract

IMPORTANCE

To our knowledge, no previous epidemiologic study has investigated the association between all antioxidants in the diet and age-related cataract. The total antioxidant capacity (TAC) concept aims to measure the capacity from all antioxidants in the diet by also taking synergistic effects into account.

OBJECTIVE

To investigate the association between the TAC of the diet and the incidence of age-related cataract in a population-based prospective cohort of middle-aged and elderly women.

DESIGN, SETTING, AND PARTICIPANTS

Questionnaire-based nutrition survey within the prospective Swedish Mammography Cohort study, which included 30,607 women (aged 49-83 years) who were observed for age-related cataract incidence for a mean of 7.7 years.

EXPOSURE

The TAC of the diet was estimated using a database of foods analyzed with the oxygen radical absorbance capacity assay.

MAIN OUTCOMES AND MEASURES

Information on incident age-related cataract diagnosis and extraction was collected through linkage to registers in the study area.

RESULTS

There were 4309 incident cases of age-related cataracts during the mean 7.7 years of follow-up (234,371 person-years). The multivariable rate ratio in the highest quintile of the TAC of the diet compared with the lowest was 0.87 (95% CI, 0.79-0.96; P for trend = .03). The main contributors to dietary TAC in the study population were fruit and vegetables (44.3%), whole grains (17.0%), and coffee (15.1%).

CONCLUSIONS AND RELEVANCE

Dietary TAC was inversely associated with the risk of age-related cataract. Future studies examining all antioxidants in the diet in relation to age-related cataract are needed to confirm or refute our findings.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

    ,

    Department of Ophthalmology, Örebro University Hospital, Örebro University, Örebro, Sweden.

    ,

    Division of Biochemical Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

    Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

    Source

    JAMA ophthalmology 132:3 2014 Mar pg 247-52

    MeSH

    Aged
    Aged, 80 and over
    Aging
    Antioxidants
    Cataract
    Cataract Extraction
    Diet
    Feeding Behavior
    Female
    Follow-Up Studies
    Humans
    Incidence
    Middle Aged
    Nutrition Surveys
    Proportional Hazards Models
    Prospective Studies
    Risk Factors
    Surveys and Questionnaires
    Sweden
    Women's Health

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24370844

    Citation

    Rautiainen, Susanne, et al. "Total Antioxidant Capacity of the Diet and Risk of Age-related Cataract: a Population-based Prospective Cohort of Women." JAMA Ophthalmology, vol. 132, no. 3, 2014, pp. 247-52.
    Rautiainen S, Lindblad BE, Morgenstern R, et al. Total antioxidant capacity of the diet and risk of age-related cataract: a population-based prospective cohort of women. JAMA Ophthalmol. 2014;132(3):247-52.
    Rautiainen, S., Lindblad, B. E., Morgenstern, R., & Wolk, A. (2014). Total antioxidant capacity of the diet and risk of age-related cataract: a population-based prospective cohort of women. JAMA Ophthalmology, 132(3), pp. 247-52. doi:10.1001/jamaophthalmol.2013.6241.
    Rautiainen S, et al. Total Antioxidant Capacity of the Diet and Risk of Age-related Cataract: a Population-based Prospective Cohort of Women. JAMA Ophthalmol. 2014;132(3):247-52. PubMed PMID: 24370844.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Total antioxidant capacity of the diet and risk of age-related cataract: a population-based prospective cohort of women. AU - Rautiainen,Susanne, AU - Lindblad,Birgitta Ejdervik, AU - Morgenstern,Ralf, AU - Wolk,Alicja, PY - 2013/12/28/entrez PY - 2013/12/29/pubmed PY - 2014/5/27/medline SP - 247 EP - 52 JF - JAMA ophthalmology JO - JAMA Ophthalmol VL - 132 IS - 3 N2 - IMPORTANCE: To our knowledge, no previous epidemiologic study has investigated the association between all antioxidants in the diet and age-related cataract. The total antioxidant capacity (TAC) concept aims to measure the capacity from all antioxidants in the diet by also taking synergistic effects into account. OBJECTIVE: To investigate the association between the TAC of the diet and the incidence of age-related cataract in a population-based prospective cohort of middle-aged and elderly women. DESIGN, SETTING, AND PARTICIPANTS: Questionnaire-based nutrition survey within the prospective Swedish Mammography Cohort study, which included 30,607 women (aged 49-83 years) who were observed for age-related cataract incidence for a mean of 7.7 years. EXPOSURE: The TAC of the diet was estimated using a database of foods analyzed with the oxygen radical absorbance capacity assay. MAIN OUTCOMES AND MEASURES: Information on incident age-related cataract diagnosis and extraction was collected through linkage to registers in the study area. RESULTS: There were 4309 incident cases of age-related cataracts during the mean 7.7 years of follow-up (234,371 person-years). The multivariable rate ratio in the highest quintile of the TAC of the diet compared with the lowest was 0.87 (95% CI, 0.79-0.96; P for trend = .03). The main contributors to dietary TAC in the study population were fruit and vegetables (44.3%), whole grains (17.0%), and coffee (15.1%). CONCLUSIONS AND RELEVANCE: Dietary TAC was inversely associated with the risk of age-related cataract. Future studies examining all antioxidants in the diet in relation to age-related cataract are needed to confirm or refute our findings. SN - 2168-6173 UR - https://www.unboundmedicine.com/medline/citation/24370844/full_citation L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/10.1001/jamaophthalmol.2013.6241 DB - PRIME DP - Unbound Medicine ER -