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Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study.

Abstract

Ashwagandha (Withania somnifera) has been described in traditional Indian Ayurvedic medicine as an aphrodisiac that can be used to treat male sexual dysfunction and infertility. This pilot study was conducted to evaluate the spermatogenic activity of Ashwagandha root extract in oligospermic patients. Forty-six male patients with oligospermia (sperm count < 20 million/mL semen) were enrolled and randomized either to treatment (n = 21) with a full-spectrum root extract of Ashwagandha (675 mg/d in three doses for 90 days) or to placebo (n = 25) in the same protocol. Semen parameters and serum hormone levels were estimated at the end of 90-day treatment. There was a 167% increase in sperm count (9.59 ± 4.37 × 10(6)/mL to 25.61 ± 8.6 × 10(6)/mL; P < 0.0001), 53% increase in semen volume (1.74 ± 0.58 mL to 2.76 ± 0.60 mL; P < 0.0001), and 57% increase in sperm motility (18.62 ± 6.11% to 29.19 ± 6.31%; P < 0.0001) on day 90 from baseline. The improvement in these parameters was minimal in the placebo-treated group. Furthermore, a significantly greater improvement and regulation were observed in serum hormone levels with the Ashwagandha treatment as compared to the placebo. The present study adds to the evidence on the therapeutic value of Ashwagandha (Withania somnifera), as attributed in Ayurveda for the treatment of oligospermia leading to infertility.

Authors+Show Affiliations

Mahalaxmi Clinic, Nanaddham, Sulochana Shetty Marg, Sion (E), Mumbai, Maharashtra 400022, India.Department of Pharmacology, B.V.D.U. Dental College & Hospital, Sector-7, C.B.D., Belpada, Navi Mumbai, Maharashtra 400614, India.Trupti Hospital & Santati Fertility Center, Thane, Maharashtra 400607, India.Arya Clinic, Thane, Maharashtra 400601, India.Arogyadham, Manpada, Thane, Maharashtra 400607, India.Trupti Hospital & Santati Fertility Center, Thane, Maharashtra 400607, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24371462

Citation

Ambiye, Vijay R., et al. "Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania Somnifera) in Oligospermic Males: a Pilot Study." Evidence-based Complementary and Alternative Medicine : ECAM, vol. 2013, 2013, p. 571420.
Ambiye VR, Langade D, Dongre S, et al. Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study. Evid Based Complement Alternat Med. 2013;2013:571420.
Ambiye, V. R., Langade, D., Dongre, S., Aptikar, P., Kulkarni, M., & Dongre, A. (2013). Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study. Evidence-based Complementary and Alternative Medicine : ECAM, 2013, 571420. https://doi.org/10.1155/2013/571420
Ambiye VR, et al. Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania Somnifera) in Oligospermic Males: a Pilot Study. Evid Based Complement Alternat Med. 2013;2013:571420. PubMed PMID: 24371462.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study. AU - Ambiye,Vijay R, AU - Langade,Deepak, AU - Dongre,Swati, AU - Aptikar,Pradnya, AU - Kulkarni,Madhura, AU - Dongre,Atul, Y1 - 2013/11/28/ PY - 2013/08/26/received PY - 2013/10/28/revised PY - 2013/11/01/accepted PY - 2013/12/28/entrez PY - 2013/12/29/pubmed PY - 2013/12/29/medline SP - 571420 EP - 571420 JF - Evidence-based complementary and alternative medicine : eCAM JO - Evid Based Complement Alternat Med VL - 2013 N2 - Ashwagandha (Withania somnifera) has been described in traditional Indian Ayurvedic medicine as an aphrodisiac that can be used to treat male sexual dysfunction and infertility. This pilot study was conducted to evaluate the spermatogenic activity of Ashwagandha root extract in oligospermic patients. Forty-six male patients with oligospermia (sperm count < 20 million/mL semen) were enrolled and randomized either to treatment (n = 21) with a full-spectrum root extract of Ashwagandha (675 mg/d in three doses for 90 days) or to placebo (n = 25) in the same protocol. Semen parameters and serum hormone levels were estimated at the end of 90-day treatment. There was a 167% increase in sperm count (9.59 ± 4.37 × 10(6)/mL to 25.61 ± 8.6 × 10(6)/mL; P < 0.0001), 53% increase in semen volume (1.74 ± 0.58 mL to 2.76 ± 0.60 mL; P < 0.0001), and 57% increase in sperm motility (18.62 ± 6.11% to 29.19 ± 6.31%; P < 0.0001) on day 90 from baseline. The improvement in these parameters was minimal in the placebo-treated group. Furthermore, a significantly greater improvement and regulation were observed in serum hormone levels with the Ashwagandha treatment as compared to the placebo. The present study adds to the evidence on the therapeutic value of Ashwagandha (Withania somnifera), as attributed in Ayurveda for the treatment of oligospermia leading to infertility. SN - 1741-427X UR - https://www.unboundmedicine.com/medline/citation/24371462/Clinical_Evaluation_of_the_Spermatogenic_Activity_of_the_Root_Extract_of_Ashwagandha__Withania_somnifera__in_Oligospermic_Males:_A_Pilot_Study_ L2 - https://doi.org/10.1155/2013/571420 DB - PRIME DP - Unbound Medicine ER -
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