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New triterpenoid saponins from Ilex cornuta and their protective effects against H2O2-induced myocardial cell injury.
J Agric Food Chem. 2014 Jan 15; 62(2):488-96.JA

Abstract

Five new triterpenoid saponins, 1-5, together with 10 known ones, 6-15 were isolated from the aerial parts of Ilex cornuta. The structures of compounds 1-5 were determined as 3β-O-α-L-arabinopyranosyl-19α,23-dihydroxy-20α-urs-12-en-28-oic acid 28-O-β-D-glucopyranosyl ester, 1; 3β-O-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl-19-hydroxy-20α-urs-12-en-28-oic acid 28-O-β-D-glucopyranosyl ester, 2; 19α,23-dihydroxyurs-12-en-28-oic acid 3β-O-β-D-glucuronopyranoside-6-O-methyl ester, 3; 19α,23-dihydroxyurs-12-en-28-oic acid 3β-O-[β-D-glucuronopyranoside-6-O-methyl ester]-28-O-β-D-glucopyranosyl ester, 4; and 3β-O-[α-L-arabinopyranosyl-(1→2)-β-D-glucuronic acid]-oleanolic acid 28-O-β-D-glucopyranosyl ester, 5, on the basis of spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1D and 2D NMR) and chemical reactions. Protective effects of compounds 1-15 were tested against H2O2-induced H9c2 cardiomyocyte injury, and the data showed that compounds 1, 4, 6, and 13 had significant cell-protective effects. No significant DPPH radical scavenging activity was observed for compounds 1-15.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Li S
College of Pharmaceutical Science, Soochow University , Suzhou 215123, China.
Zhao J
No affiliation info available
Liu Y
No affiliation info available
Chen Z
No affiliation info available
Xu Q
No affiliation info available
Khan IA
No affiliation info available
Yang S
No affiliation info available

MeSH

Cardiotonic AgentsCell LineCoronary DiseaseFree Radical ScavengersHydrogen PeroxideIlexMolecular StructureMyocytes, CardiacOxidative StressPlant Components, AerialPlant ExtractsSaponinsTriterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24372391

Citation

Li, Shanshan, et al. "New Triterpenoid Saponins From Ilex Cornuta and Their Protective Effects Against H2O2-induced Myocardial Cell Injury." Journal of Agricultural and Food Chemistry, vol. 62, no. 2, 2014, pp. 488-96.
Li S, Zhao J, Liu Y, et al. New triterpenoid saponins from Ilex cornuta and their protective effects against H2O2-induced myocardial cell injury. J Agric Food Chem. 2014;62(2):488-96.
Li, S., Zhao, J., Liu, Y., Chen, Z., Xu, Q., Khan, I. A., & Yang, S. (2014). New triterpenoid saponins from Ilex cornuta and their protective effects against H2O2-induced myocardial cell injury. Journal of Agricultural and Food Chemistry, 62(2), 488-96. https://doi.org/10.1021/jf4046667
Li S, et al. New Triterpenoid Saponins From Ilex Cornuta and Their Protective Effects Against H2O2-induced Myocardial Cell Injury. J Agric Food Chem. 2014 Jan 15;62(2):488-96. PubMed PMID: 24372391.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New triterpenoid saponins from Ilex cornuta and their protective effects against H2O2-induced myocardial cell injury. AU - Li,Shanshan, AU - Zhao,Jianping, AU - Liu,Yanli, AU - Chen,Zhong, AU - Xu,Qiongming, AU - Khan,Ikhlas A, AU - Yang,Shilin, Y1 - 2014/01/06/ PY - 2013/12/31/entrez PY - 2014/1/1/pubmed PY - 2015/9/5/medline KW - Aquifoliaceae KW - DPPH radical scavenging activity KW - Ilex cornuta KW - cardiomyocyte oxidative injury KW - structure identification KW - triterpenoid saponins SP - 488 EP - 96 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 62 IS - 2 N2 - Five new triterpenoid saponins, 1-5, together with 10 known ones, 6-15 were isolated from the aerial parts of Ilex cornuta. The structures of compounds 1-5 were determined as 3β-O-α-L-arabinopyranosyl-19α,23-dihydroxy-20α-urs-12-en-28-oic acid 28-O-β-D-glucopyranosyl ester, 1; 3β-O-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl-19-hydroxy-20α-urs-12-en-28-oic acid 28-O-β-D-glucopyranosyl ester, 2; 19α,23-dihydroxyurs-12-en-28-oic acid 3β-O-β-D-glucuronopyranoside-6-O-methyl ester, 3; 19α,23-dihydroxyurs-12-en-28-oic acid 3β-O-[β-D-glucuronopyranoside-6-O-methyl ester]-28-O-β-D-glucopyranosyl ester, 4; and 3β-O-[α-L-arabinopyranosyl-(1→2)-β-D-glucuronic acid]-oleanolic acid 28-O-β-D-glucopyranosyl ester, 5, on the basis of spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1D and 2D NMR) and chemical reactions. Protective effects of compounds 1-15 were tested against H2O2-induced H9c2 cardiomyocyte injury, and the data showed that compounds 1, 4, 6, and 13 had significant cell-protective effects. No significant DPPH radical scavenging activity was observed for compounds 1-15. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/24372391/New_triterpenoid_saponins_from_Ilex_cornuta_and_their_protective_effects_against_H2O2_induced_myocardial_cell_injury_ DB - PRIME DP - Unbound Medicine ER -