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Prevalence of high-risk human papillomavirus type 16 and 18 in oral and cervical cancers in population from Gujarat, West India.
J Oral Pathol Med. 2014 Apr; 43(4):293-7.JO

Abstract

BACKGROUND

Oral and cervical cancers are major malignancies in men and women, respectively, in India. This study evaluated occurrence of human papillomavirus (HPV) 16 and 18 infections in oral and cervical cancers to estimate HPV-associated burden of these cancers in the population from Gujarat, West India.

METHODS

A total of 97 malignant oral carcinoma tissues and 52 cervical carcinoma tissues were analyzed by type-specific PCR for the presence of HPV type 16 and 18 infections.

RESULTS

None of the oral cancer patients revealed the presence of HPV type 16 and 18 infection. In cervical cancer, 31 (59.6%) patients were infected with HPV 16 and 18. Of these 31 HPV-positive cervical cancer patients, 28 (90.3%) were infected with HPV 16 and 3 (9.7%) were infected with HPV 18.

CONCLUSION

The results suggested that HPV 16 and 18 do not play an important role in oral carcinogenesis in the population from Gujarat, West India. However, HPV 16 is highly prevalent in the cervical cancer patients, which may be considered for planning of prevention programs such as screening and vaccination in women from this region.

Authors+Show Affiliations

Biochemistry Research Division, The Gujarat Cancer & Research Institute, Ahmedabad, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24372728

Citation

Patel, Kinjal R., et al. "Prevalence of High-risk Human Papillomavirus Type 16 and 18 in Oral and Cervical Cancers in Population From Gujarat, West India." Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, vol. 43, no. 4, 2014, pp. 293-7.
Patel KR, Vajaria BN, Begum R, et al. Prevalence of high-risk human papillomavirus type 16 and 18 in oral and cervical cancers in population from Gujarat, West India. J Oral Pathol Med. 2014;43(4):293-7.
Patel, K. R., Vajaria, B. N., Begum, R., Desai, A., Patel, J. B., Shah, F. D., Shukla, S. N., & Patel, P. S. (2014). Prevalence of high-risk human papillomavirus type 16 and 18 in oral and cervical cancers in population from Gujarat, West India. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 43(4), 293-7. https://doi.org/10.1111/jop.12147
Patel KR, et al. Prevalence of High-risk Human Papillomavirus Type 16 and 18 in Oral and Cervical Cancers in Population From Gujarat, West India. J Oral Pathol Med. 2014;43(4):293-7. PubMed PMID: 24372728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of high-risk human papillomavirus type 16 and 18 in oral and cervical cancers in population from Gujarat, West India. AU - Patel,Kinjal R, AU - Vajaria,Bhairavi N, AU - Begum,Rasheedunnisa, AU - Desai,Ava, AU - Patel,Jayendra B, AU - Shah,Franky D, AU - Shukla,Shilin N, AU - Patel,Prabhudas S, Y1 - 2013/12/30/ PY - 2013/11/28/accepted PY - 2013/12/31/entrez PY - 2014/1/1/pubmed PY - 2015/1/13/medline KW - cervical cancer KW - human papillomavirus KW - oral cancer SP - 293 EP - 7 JF - Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology JO - J Oral Pathol Med VL - 43 IS - 4 N2 - BACKGROUND: Oral and cervical cancers are major malignancies in men and women, respectively, in India. This study evaluated occurrence of human papillomavirus (HPV) 16 and 18 infections in oral and cervical cancers to estimate HPV-associated burden of these cancers in the population from Gujarat, West India. METHODS: A total of 97 malignant oral carcinoma tissues and 52 cervical carcinoma tissues were analyzed by type-specific PCR for the presence of HPV type 16 and 18 infections. RESULTS: None of the oral cancer patients revealed the presence of HPV type 16 and 18 infection. In cervical cancer, 31 (59.6%) patients were infected with HPV 16 and 18. Of these 31 HPV-positive cervical cancer patients, 28 (90.3%) were infected with HPV 16 and 3 (9.7%) were infected with HPV 18. CONCLUSION: The results suggested that HPV 16 and 18 do not play an important role in oral carcinogenesis in the population from Gujarat, West India. However, HPV 16 is highly prevalent in the cervical cancer patients, which may be considered for planning of prevention programs such as screening and vaccination in women from this region. SN - 1600-0714 UR - https://www.unboundmedicine.com/medline/citation/24372728/Prevalence_of_high_risk_human_papillomavirus_type_16_and_18_in_oral_and_cervical_cancers_in_population_from_Gujarat_West_India_ L2 - https://doi.org/10.1111/jop.12147 DB - PRIME DP - Unbound Medicine ER -