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Is statin-induced diabetes clinically relevant? A comprehensive review of the literature.
Diabetes Obes Metab 2014; 16(8):689-94DO

Abstract

In those predisposed to the development of diabetes (the insulin resistant, obese and older patients) statins may increase the risk of developing diabetes. Despite the fact that the conversion to diabetes is generated from post hoc analyses, it seems to be a class effect with a dose-response relationship. However, statins have not been clearly shown to increase diabetic microvascular complications (retinopathy, nephropathy and neuropathy). Thus, the clinical significance of increased glucose levels in patients treated on statins is uncertain. While the exact mechanism for how statins increase the risk of diabetes is unknown, a possible explanation is through a reduction in adiponectin levels. Despite the fact that higher statin doses are more likely to lead to new-onset diabetes, for every case of diabetes caused, there are approximately three cardiovascular events reduced with high dose versus moderate dose statin therapy. Overall, the small risk of developing type 2 diabetes with statin therapy is far outweighed by the potential of statins to decrease cardiac events.

Authors+Show Affiliations

Southside Endocrinology, University of Alabama at Birmingham, Birmingham, AL, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24373206

Citation

Bell, D S H., et al. "Is Statin-induced Diabetes Clinically Relevant? a Comprehensive Review of the Literature." Diabetes, Obesity & Metabolism, vol. 16, no. 8, 2014, pp. 689-94.
Bell DS, DiNicolantonio JJ, O'Keefe JH. Is statin-induced diabetes clinically relevant? A comprehensive review of the literature. Diabetes Obes Metab. 2014;16(8):689-94.
Bell, D. S., DiNicolantonio, J. J., & O'Keefe, J. H. (2014). Is statin-induced diabetes clinically relevant? A comprehensive review of the literature. Diabetes, Obesity & Metabolism, 16(8), pp. 689-94. doi:10.1111/dom.12254.
Bell DS, DiNicolantonio JJ, O'Keefe JH. Is Statin-induced Diabetes Clinically Relevant? a Comprehensive Review of the Literature. Diabetes Obes Metab. 2014;16(8):689-94. PubMed PMID: 24373206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is statin-induced diabetes clinically relevant? A comprehensive review of the literature. AU - Bell,D S H, AU - DiNicolantonio,J J, AU - O'Keefe,J H, Y1 - 2014/01/20/ PY - 2013/09/13/received PY - 2013/10/31/revised PY - 2013/12/17/accepted PY - 2013/12/31/entrez PY - 2014/1/1/pubmed PY - 2015/3/31/medline KW - diabetes mellitus KW - drug mechanism KW - drug utilization SP - 689 EP - 94 JF - Diabetes, obesity & metabolism JO - Diabetes Obes Metab VL - 16 IS - 8 N2 - In those predisposed to the development of diabetes (the insulin resistant, obese and older patients) statins may increase the risk of developing diabetes. Despite the fact that the conversion to diabetes is generated from post hoc analyses, it seems to be a class effect with a dose-response relationship. However, statins have not been clearly shown to increase diabetic microvascular complications (retinopathy, nephropathy and neuropathy). Thus, the clinical significance of increased glucose levels in patients treated on statins is uncertain. While the exact mechanism for how statins increase the risk of diabetes is unknown, a possible explanation is through a reduction in adiponectin levels. Despite the fact that higher statin doses are more likely to lead to new-onset diabetes, for every case of diabetes caused, there are approximately three cardiovascular events reduced with high dose versus moderate dose statin therapy. Overall, the small risk of developing type 2 diabetes with statin therapy is far outweighed by the potential of statins to decrease cardiac events. SN - 1463-1326 UR - https://www.unboundmedicine.com/medline/citation/24373206/Is_statin_induced_diabetes_clinically_relevant_A_comprehensive_review_of_the_literature_ L2 - https://doi.org/10.1111/dom.12254 DB - PRIME DP - Unbound Medicine ER -