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Lavender (Lavandula stoechas L.) essential oils attenuate hyperglycemia and protect against oxidative stress in alloxan-induced diabetic rats.
Lipids Health Dis. 2013 Dec 28; 12:189.LH

Abstract

BACKGROUND

The present study described the phytochemical profile of Lavandula stoechas essential oils, collected in the area of Ain-Draham (North-West of Tunisia), as well as their protective effects against alloxan-induced diabetes and oxidative stress in rat.

METHODS

Essential oils samples were obtained from the aerial parts of the plant by hydrodistillation and analyzed by GC-MS. Rats were divided into four groups: Healthy Control (HC); Diabetic Control (DC); Healthy + Essential Oils (H + EO) and Diabetic + Essential Oils (D + EO).Antidiabetic and antioxidant activities were evaluated after subacute intraperitoneally injection of Lavandula stoechas essential oils (50 mg/kg b.w., i.p.) to rats during 15 days.

RESULTS

The principal compounds detected are: D-Fenchone (29.28%), α-pinene (23.18%), Camphor (15.97%), Camphene (7.83%), Eucapur (3.29%), Limonene, (2.71%) Linalool, (2.01%) Endobornyl Acetate (1.03%). The essential oils also contained smaller percentages of Tricyclene, Cymene, Delta-Cadinene, Selina-3,7(11)-diene. Furthermore, we found that Lavandula stoechas essential oils significantly protected against the increase of blood glucose as well as the decrease of antioxidant enzyme activities induced by aloxan treatment. Subacute essential oils treatment induced a decrease of lipoperoxidation as well as an increase of antioxidant enzyme activities.

CONCLUSIONS

These findings suggested that lavandula stoechas essential oils protected against diabetes and oxidative stress induced by alloxan treatment. These effects are in partly due to its potent antioxidant properties.

Links

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Authors+Show Affiliations

Sebai H
No affiliation info available
Selmi S
Département des Sciences de la Vie, Laboratore de Physiologie Animale, Faculté des Sciences de Tunis, Tunis 1060, Tunisia. slimen.selmi@gmail.com.
Rtibi K
No affiliation info available
Souli A
No affiliation info available
Gharbi N
No affiliation info available
Sakly M
No affiliation info available

MeSH

AlloxanAnimalsAntioxidantsBiphenyl CompoundsDiabetes Mellitus, ExperimentalGas Chromatography-Mass SpectrometryHyperglycemiaHypoglycemic AgentsInjections, IntraperitonealKidneyLavandulaLipid PeroxidationLiverMaleMalondialdehydeNorbornanesOils, VolatileOxidative StressPicratesPlant Components, AerialRatsRats, WistarTerpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24373672

Citation

Sebai, Hichem, et al. "Lavender (Lavandula Stoechas L.) Essential Oils Attenuate Hyperglycemia and Protect Against Oxidative Stress in Alloxan-induced Diabetic Rats." Lipids in Health and Disease, vol. 12, 2013, p. 189.
Sebai H, Selmi S, Rtibi K, et al. Lavender (Lavandula stoechas L.) essential oils attenuate hyperglycemia and protect against oxidative stress in alloxan-induced diabetic rats. Lipids Health Dis. 2013;12:189.
Sebai, H., Selmi, S., Rtibi, K., Souli, A., Gharbi, N., & Sakly, M. (2013). Lavender (Lavandula stoechas L.) essential oils attenuate hyperglycemia and protect against oxidative stress in alloxan-induced diabetic rats. Lipids in Health and Disease, 12, 189. https://doi.org/10.1186/1476-511X-12-189
Sebai H, et al. Lavender (Lavandula Stoechas L.) Essential Oils Attenuate Hyperglycemia and Protect Against Oxidative Stress in Alloxan-induced Diabetic Rats. Lipids Health Dis. 2013 Dec 28;12:189. PubMed PMID: 24373672.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lavender (Lavandula stoechas L.) essential oils attenuate hyperglycemia and protect against oxidative stress in alloxan-induced diabetic rats. AU - Sebai,Hichem, AU - Selmi,Slimen, AU - Rtibi,Kais, AU - Souli,Abdelaziz, AU - Gharbi,Najoua, AU - Sakly,Mohsen, Y1 - 2013/12/28/ PY - 2013/08/07/received PY - 2013/12/21/accepted PY - 2013/12/31/entrez PY - 2014/1/1/pubmed PY - 2014/7/9/medline SP - 189 EP - 189 JF - Lipids in health and disease JO - Lipids Health Dis VL - 12 N2 - BACKGROUND: The present study described the phytochemical profile of Lavandula stoechas essential oils, collected in the area of Ain-Draham (North-West of Tunisia), as well as their protective effects against alloxan-induced diabetes and oxidative stress in rat. METHODS: Essential oils samples were obtained from the aerial parts of the plant by hydrodistillation and analyzed by GC-MS. Rats were divided into four groups: Healthy Control (HC); Diabetic Control (DC); Healthy + Essential Oils (H + EO) and Diabetic + Essential Oils (D + EO).Antidiabetic and antioxidant activities were evaluated after subacute intraperitoneally injection of Lavandula stoechas essential oils (50 mg/kg b.w., i.p.) to rats during 15 days. RESULTS: The principal compounds detected are: D-Fenchone (29.28%), α-pinene (23.18%), Camphor (15.97%), Camphene (7.83%), Eucapur (3.29%), Limonene, (2.71%) Linalool, (2.01%) Endobornyl Acetate (1.03%). The essential oils also contained smaller percentages of Tricyclene, Cymene, Delta-Cadinene, Selina-3,7(11)-diene. Furthermore, we found that Lavandula stoechas essential oils significantly protected against the increase of blood glucose as well as the decrease of antioxidant enzyme activities induced by aloxan treatment. Subacute essential oils treatment induced a decrease of lipoperoxidation as well as an increase of antioxidant enzyme activities. CONCLUSIONS: These findings suggested that lavandula stoechas essential oils protected against diabetes and oxidative stress induced by alloxan treatment. These effects are in partly due to its potent antioxidant properties. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/24373672/Lavender__Lavandula_stoechas_L___essential_oils_attenuate_hyperglycemia_and_protect_against_oxidative_stress_in_alloxan_induced_diabetic_rats_ DB - PRIME DP - Unbound Medicine ER -