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Neuroprotective effect of anthocyanins on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia in rats.
Int J Dev Neurosci. 2014 Apr; 33:88-97.IJ

Abstract

Anthocyanins are a group of natural phenolic compounds responsible for the color to plants and fruits. These compounds might have beneficial effects on memory and have antioxidant properties. In the present study we have investigated the therapeutic efficacy of anthocyanins in an animal model of cognitive deficits, associated to Alzheimer's disease, induced by scopolamine. We evaluated whether anthocyanins protect the effects caused by SCO on nitrite/nitrate (NOx) levels and Na(+),K(+)-ATPase and Ca(2+)-ATPase and acetylcholinesterase (AChE) activities in the cerebral cortex and hippocampus (of rats. We used 4 different groups of animals: control (CTRL), anthocyanins treated (ANT), scopolamine-challenged (SCO), and scopolamine+anthocyanins (SCO+ANT). After seven days of treatment with ANT (200mgkg(-1); oral), the animals were SCO injected (1mgkg(-1); IP) and were performed the behavior tests, and submitted to euthanasia. A memory deficit was found in SCO group, but ANT treatment prevented this impairment of memory (P<0.05). The ANT treatment per se had an anxiolytic effect. AChE activity was increased in both in cortex and hippocampus of SCO group, this effect was significantly attenuated by ANT (P<0.05). SCO decreased Na(+),K(+)-ATPase and Ca(2+)-ATPase activities in hippocampus, and ANT was able to significantly (P<0.05) prevent these effects. No significant alteration was found on NOx levels among the groups. In conclusion, the ANT is able to regulate cholinergic neurotransmission and restore the Na(+),K(+)-ATPase and Ca(2+)-ATPase activities, and also prevented memory deficits caused by scopolamine administration.

Authors+Show Affiliations

Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria RS 97105-900, Brazil. Electronic address: jessiegutierres@hotmail.com.Setor de Bioquímica e Biologia Molecular do Laboratório de Terapia Celular, Centro de Ciências Rurais, Universidade Federal de Santa Maria, Santa Maria RS 97105-900, Brazil.Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria RS 97105-900, Brazil.Center for Neuroscience and Cell Biology, Faculty of Medicine, Biochemistry Institute, University of Coimbra, 3004 Coimbra, Portugal.Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria RS 97105-900, Brazil.Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria RS 97105-900, Brazil.Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria RS 97105-900, Brazil.Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria RS 97105-900, Brazil.Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria RS 97105-900, Brazil.Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria RS 97105-900, Brazil.Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário, Capão do Leão, Pelotas RS 96010-900, Brazil.Setor de Bioquímica e Biologia Molecular do Laboratório de Terapia Celular, Centro de Ciências Rurais, Universidade Federal de Santa Maria, Santa Maria RS 97105-900, Brazil. Electronic address: cmelazzomazzanti@gmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24374256

Citation

Gutierres, Jessié M., et al. "Neuroprotective Effect of Anthocyanins On Acetylcholinesterase Activity and Attenuation of Scopolamine-induced Amnesia in Rats." International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience, vol. 33, 2014, pp. 88-97.
Gutierres JM, Carvalho FB, Schetinger MR, et al. Neuroprotective effect of anthocyanins on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia in rats. Int J Dev Neurosci. 2014;33:88-97.
Gutierres, J. M., Carvalho, F. B., Schetinger, M. R., Agostinho, P., Marisco, P. C., Vieira, J. M., Rosa, M. M., Bohnert, C., Rubin, M. A., Morsch, V. M., Spanevello, R., & Mazzanti, C. M. (2014). Neuroprotective effect of anthocyanins on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia in rats. International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience, 33, 88-97. https://doi.org/10.1016/j.ijdevneu.2013.12.006
Gutierres JM, et al. Neuroprotective Effect of Anthocyanins On Acetylcholinesterase Activity and Attenuation of Scopolamine-induced Amnesia in Rats. Int J Dev Neurosci. 2014;33:88-97. PubMed PMID: 24374256.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective effect of anthocyanins on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia in rats. AU - Gutierres,Jessié M, AU - Carvalho,Fabiano B, AU - Schetinger,Maria Rosa C, AU - Agostinho,Paula, AU - Marisco,Patricia C, AU - Vieira,Juliano M, AU - Rosa,Michele M, AU - Bohnert,Crystiani, AU - Rubin,Maribel A, AU - Morsch,Vera M, AU - Spanevello,Roselia, AU - Mazzanti,Cinthia M, Y1 - 2013/12/24/ PY - 2013/07/18/received PY - 2013/12/15/revised PY - 2013/12/16/accepted PY - 2013/12/31/entrez PY - 2014/1/1/pubmed PY - 2014/10/11/medline KW - Acetylcholinesterase KW - Anthocyanins KW - Anxiety-like behavior KW - Memory KW - Scopolamine SP - 88 EP - 97 JF - International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience JO - Int J Dev Neurosci VL - 33 N2 - Anthocyanins are a group of natural phenolic compounds responsible for the color to plants and fruits. These compounds might have beneficial effects on memory and have antioxidant properties. In the present study we have investigated the therapeutic efficacy of anthocyanins in an animal model of cognitive deficits, associated to Alzheimer's disease, induced by scopolamine. We evaluated whether anthocyanins protect the effects caused by SCO on nitrite/nitrate (NOx) levels and Na(+),K(+)-ATPase and Ca(2+)-ATPase and acetylcholinesterase (AChE) activities in the cerebral cortex and hippocampus (of rats. We used 4 different groups of animals: control (CTRL), anthocyanins treated (ANT), scopolamine-challenged (SCO), and scopolamine+anthocyanins (SCO+ANT). After seven days of treatment with ANT (200mgkg(-1); oral), the animals were SCO injected (1mgkg(-1); IP) and were performed the behavior tests, and submitted to euthanasia. A memory deficit was found in SCO group, but ANT treatment prevented this impairment of memory (P<0.05). The ANT treatment per se had an anxiolytic effect. AChE activity was increased in both in cortex and hippocampus of SCO group, this effect was significantly attenuated by ANT (P<0.05). SCO decreased Na(+),K(+)-ATPase and Ca(2+)-ATPase activities in hippocampus, and ANT was able to significantly (P<0.05) prevent these effects. No significant alteration was found on NOx levels among the groups. In conclusion, the ANT is able to regulate cholinergic neurotransmission and restore the Na(+),K(+)-ATPase and Ca(2+)-ATPase activities, and also prevented memory deficits caused by scopolamine administration. SN - 1873-474X UR - https://www.unboundmedicine.com/medline/citation/24374256/Neuroprotective_effect_of_anthocyanins_on_acetylcholinesterase_activity_and_attenuation_of_scopolamine_induced_amnesia_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0736-5748(13)00179-2 DB - PRIME DP - Unbound Medicine ER -