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Immunohistochemical analysis of mast cell infiltrates and microvessel density in oral squamous cell carcinoma.
Pol J Pathol. 2013 Dec; 64(4):276-80.PJ

Abstract

The aim of the study was to evaluate mast cell concentration and microvessel density in perilesional and intralesional regions of oral squamous cell carcinoma (OSCC) and furthermore to assess the possible relationship between the above-mentioned parameters. Paraffin-embedded specimens from 47 cases of OSCC and 12 cases of normal mucosa were investigated immunohistochemically with anti-CD-31 antibody to stain microvessels and anti-tryptase antibody to visualize mast cells. The degree of vascularization and mast cell infiltration was measured with an image analysis system. The study revealed considerably increased microvessel density and mast cell abundance in intralesional and perilesional regions of OSCCs in comparison to normal mucosa. There was a significant positive correlation between microvessel density and mast cell concentration in both localizations of OSCCs (p < 0.02, p < 0.001, respectively), whereas a comparable correlation was not observed in normal mucosa. The obtained results suggest that mast cells play an important role in the regulation of angiogenesis in OSCC, although there are aspects of their activity of potential diagnostic and therapeutic significance which require further research.

Authors+Show Affiliations

Łukasz Pyziak, Department of Nephropathology, Medical University of Lodz, Czechosłowacka 8/10, 92-216 Lodz, Poland, tel. +48 42 675 76 22, fax +48 42 679 01 91, e-mail: lukasz.pyziak@umed.lodz.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24375042

Citation

Pyziak, L, et al. "Immunohistochemical Analysis of Mast Cell Infiltrates and Microvessel Density in Oral Squamous Cell Carcinoma." Polish Journal of Pathology : Official Journal of the Polish Society of Pathologists, vol. 64, no. 4, 2013, pp. 276-80.
Pyziak L, Stasikowska-Kanicka O, Danilewicz M, et al. Immunohistochemical analysis of mast cell infiltrates and microvessel density in oral squamous cell carcinoma. Pol J Pathol. 2013;64(4):276-80.
Pyziak, L., Stasikowska-Kanicka, O., Danilewicz, M., & Wągrowska-Danilewicz, M. (2013). Immunohistochemical analysis of mast cell infiltrates and microvessel density in oral squamous cell carcinoma. Polish Journal of Pathology : Official Journal of the Polish Society of Pathologists, 64(4), 276-80.
Pyziak L, et al. Immunohistochemical Analysis of Mast Cell Infiltrates and Microvessel Density in Oral Squamous Cell Carcinoma. Pol J Pathol. 2013;64(4):276-80. PubMed PMID: 24375042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunohistochemical analysis of mast cell infiltrates and microvessel density in oral squamous cell carcinoma. AU - Pyziak,L, AU - Stasikowska-Kanicka,O, AU - Danilewicz,M, AU - Wągrowska-Danilewicz,M, PY - 2013/12/31/entrez PY - 2014/1/1/pubmed PY - 2014/7/12/medline SP - 276 EP - 80 JF - Polish journal of pathology : official journal of the Polish Society of Pathologists JO - Pol J Pathol VL - 64 IS - 4 N2 - The aim of the study was to evaluate mast cell concentration and microvessel density in perilesional and intralesional regions of oral squamous cell carcinoma (OSCC) and furthermore to assess the possible relationship between the above-mentioned parameters. Paraffin-embedded specimens from 47 cases of OSCC and 12 cases of normal mucosa were investigated immunohistochemically with anti-CD-31 antibody to stain microvessels and anti-tryptase antibody to visualize mast cells. The degree of vascularization and mast cell infiltration was measured with an image analysis system. The study revealed considerably increased microvessel density and mast cell abundance in intralesional and perilesional regions of OSCCs in comparison to normal mucosa. There was a significant positive correlation between microvessel density and mast cell concentration in both localizations of OSCCs (p < 0.02, p < 0.001, respectively), whereas a comparable correlation was not observed in normal mucosa. The obtained results suggest that mast cells play an important role in the regulation of angiogenesis in OSCC, although there are aspects of their activity of potential diagnostic and therapeutic significance which require further research. SN - 1233-9687 UR - https://www.unboundmedicine.com/medline/citation/24375042/Immunohistochemical_analysis_of_mast_cell_infiltrates_and_microvessel_density_in_oral_squamous_cell_carcinoma_ L2 - http://www.pjp.termedia.pl/showarticle.php?id=21894 DB - PRIME DP - Unbound Medicine ER -