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The effect of nebulized dorzolamide/timolol fixed combination mist versus drops on retrobulbar blood flow and intraocular pressure in glaucoma patients.
Medicina (Kaunas). 2013; 49(7):310-4.M

Abstract

OBJECTIVE

The aim of this study was to evaluate intraocular pressure (IOP), retrobulbar blood flow (RBF), and ocular side effects after the application of topical dorzolamide/timolol fixed combination (DTFC) drops vs topical nebulized DTFC mist in patients with primary open-angle glaucoma.

MATERIAL AND METHODS

A total of 15 POAG patients were enrolled in a prospective study. Retrobulbar blood flow was measured in the ophthalmic (OA) and central retinal (CRA) arteries using color Doppler imaging. DTFC mist or drops were applied to the experimental eye, and it was examined after 15 and 60 minutes. DTFC mist was applied 6 times for 30 seconds using a misting device.

RESULTS

DTFC mist significantly increased peak-systolic (PSV) and end-diastolic (EDV) velocities after 15 and 60 minutes in both the arteries (OA: increase of 12.5% and 9.6% in PSV, P=0.01; increase of 25.8% and 23.1% in EDV, P=0.03; CRA: increase of 11.5% and 8.7% in PSV, increase of 32% and 21.6% in EDV, respectively, P<0.05). DTFC drops had a similar effect on PSV and EDV in the CRA after 15 and 60 minutes (increase of 8.1% and 9.6% in PSV; increase of 17.1% and 23% in EDV, respectively, P=0.03), but a significant effect on PSV and EDV in the OA was documented only after 15 minutes (increase of 9% and 21.4%, respectively, P=0.02). DTFC mist reduced the resistance index in the CRA after 15 and 60 minutes (decrease of 8.5% and 10.2%, respectively, P=0.04). Both methodologies showed a significant decrease in IOP after 15 and 60 minutes (P<0.05). All patients complained of ocular irritation after drop application, and 1 patient complained of general weakness after mist treatment.

CONCLUSIONS

Nebulized DTFC mist significantly reduced IOP and increased blood flow in the OA and the CRA, causing no ocular irritation as compared with traditional DTFC drop methodology.

Authors+Show Affiliations

Department of Ophthalmology, Medical Academy, Lithuanian University of Health Sciences, Eivenių 2, 50161 Kaunas, Lithuania. ingrida.januleviciene@kaunoklinikos.lt.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24375242

Citation

Janulevičienė, Ingrida, et al. "The Effect of Nebulized Dorzolamide/timolol Fixed Combination Mist Versus Drops On Retrobulbar Blood Flow and Intraocular Pressure in Glaucoma Patients." Medicina (Kaunas, Lithuania), vol. 49, no. 7, 2013, pp. 310-4.
Janulevičienė I, Šiaudvytytė L, Baršauskaitė R, et al. The effect of nebulized dorzolamide/timolol fixed combination mist versus drops on retrobulbar blood flow and intraocular pressure in glaucoma patients. Medicina (Kaunas). 2013;49(7):310-4.
Janulevičienė, I., Šiaudvytytė, L., Baršauskaitė, R., Dilienė, V., Kuzmienė, L., Siesky, B., & Harris, A. (2013). The effect of nebulized dorzolamide/timolol fixed combination mist versus drops on retrobulbar blood flow and intraocular pressure in glaucoma patients. Medicina (Kaunas, Lithuania), 49(7), 310-4.
Janulevičienė I, et al. The Effect of Nebulized Dorzolamide/timolol Fixed Combination Mist Versus Drops On Retrobulbar Blood Flow and Intraocular Pressure in Glaucoma Patients. Medicina (Kaunas). 2013;49(7):310-4. PubMed PMID: 24375242.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of nebulized dorzolamide/timolol fixed combination mist versus drops on retrobulbar blood flow and intraocular pressure in glaucoma patients. AU - Janulevičienė,Ingrida, AU - Šiaudvytytė,Lina, AU - Baršauskaitė,Rūta, AU - Dilienė,Vaida, AU - Kuzmienė,Loreta, AU - Siesky,Brent, AU - Harris,Alon, PY - 2013/12/31/entrez PY - 2014/1/1/pubmed PY - 2014/12/19/medline SP - 310 EP - 4 JF - Medicina (Kaunas, Lithuania) JO - Medicina (Kaunas) VL - 49 IS - 7 N2 - OBJECTIVE: The aim of this study was to evaluate intraocular pressure (IOP), retrobulbar blood flow (RBF), and ocular side effects after the application of topical dorzolamide/timolol fixed combination (DTFC) drops vs topical nebulized DTFC mist in patients with primary open-angle glaucoma. MATERIAL AND METHODS: A total of 15 POAG patients were enrolled in a prospective study. Retrobulbar blood flow was measured in the ophthalmic (OA) and central retinal (CRA) arteries using color Doppler imaging. DTFC mist or drops were applied to the experimental eye, and it was examined after 15 and 60 minutes. DTFC mist was applied 6 times for 30 seconds using a misting device. RESULTS: DTFC mist significantly increased peak-systolic (PSV) and end-diastolic (EDV) velocities after 15 and 60 minutes in both the arteries (OA: increase of 12.5% and 9.6% in PSV, P=0.01; increase of 25.8% and 23.1% in EDV, P=0.03; CRA: increase of 11.5% and 8.7% in PSV, increase of 32% and 21.6% in EDV, respectively, P<0.05). DTFC drops had a similar effect on PSV and EDV in the CRA after 15 and 60 minutes (increase of 8.1% and 9.6% in PSV; increase of 17.1% and 23% in EDV, respectively, P=0.03), but a significant effect on PSV and EDV in the OA was documented only after 15 minutes (increase of 9% and 21.4%, respectively, P=0.02). DTFC mist reduced the resistance index in the CRA after 15 and 60 minutes (decrease of 8.5% and 10.2%, respectively, P=0.04). Both methodologies showed a significant decrease in IOP after 15 and 60 minutes (P<0.05). All patients complained of ocular irritation after drop application, and 1 patient complained of general weakness after mist treatment. CONCLUSIONS: Nebulized DTFC mist significantly reduced IOP and increased blood flow in the OA and the CRA, causing no ocular irritation as compared with traditional DTFC drop methodology. SN - 1648-9144 UR - https://www.unboundmedicine.com/medline/citation/24375242/The_effect_of_nebulized_dorzolamide/timolol_fixed_combination_mist_versus_drops_on_retrobulbar_blood_flow_and_intraocular_pressure_in_glaucoma_patients_ L2 - http://medicina.lsmuni.lt/med/1307/1307-02e.pdf DB - PRIME DP - Unbound Medicine ER -