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Oleuropein induces apoptosis via the p53 pathway in breast cancer cells.
Asian Pac J Cancer Prev. 2014 Jan; 14(11):6739-42.AP

Abstract

BACKGROUND

Breast cancer is a major health problem worldwide. Olive oil induces apoptosis in some cancer cells due to phenolic compounds like oleuropein. Although oleuropein has anticancer activity, the underlying mechanisms of action remain unknown. The study aimed to assess the mechanism of oleuropin-induced breast cancer cell apoptosis.

MATERIALS AND METHODS

p53, Bcl-2 and Bax gene expression was evaluated by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR) in luminal MCF-7 cells.

RESULTS

Oleuropein-induced apoptosis was accompanied by up-regulation of both p53 and Bax gene expression levels and down-regulation in Bcl2.

CONCLUSIONS

Oleuropein induces apoptosis in breast tumour cells via a p53-dependent pathway mediated by Bax and Bcl2 genes. Therefore, oleuropein may have therapeutic potential in breast cancer patients by inducing apoptosis via activation of the p53 pathway.

Authors+Show Affiliations

Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia E-mail : hildahafez@hotmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24377598

Citation

Hassan, Zeinab Korany, et al. "Oleuropein Induces Apoptosis Via the P53 Pathway in Breast Cancer Cells." Asian Pacific Journal of Cancer Prevention : APJCP, vol. 14, no. 11, 2014, pp. 6739-42.
Hassan ZK, Elamin MH, Omer SA, et al. Oleuropein induces apoptosis via the p53 pathway in breast cancer cells. Asian Pac J Cancer Prev. 2014;14(11):6739-42.
Hassan, Z. K., Elamin, M. H., Omer, S. A., Daghestani, M. H., Al-Olayan, E. S., Elobeid, M. A., & Virk, P. (2014). Oleuropein induces apoptosis via the p53 pathway in breast cancer cells. Asian Pacific Journal of Cancer Prevention : APJCP, 14(11), 6739-42.
Hassan ZK, et al. Oleuropein Induces Apoptosis Via the P53 Pathway in Breast Cancer Cells. Asian Pac J Cancer Prev. 2014;14(11):6739-42. PubMed PMID: 24377598.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oleuropein induces apoptosis via the p53 pathway in breast cancer cells. AU - Hassan,Zeinab Korany, AU - Elamin,Maha Hussein, AU - Omer,Sawsan Ali, AU - Daghestani,Maha Hassan, AU - Al-Olayan,Ebtesam Salah, AU - Elobeid,Mai Abdelrahman, AU - Virk,Promy, PY - 2014/1/1/entrez PY - 2014/1/1/pubmed PY - 2015/1/7/medline SP - 6739 EP - 42 JF - Asian Pacific journal of cancer prevention : APJCP JO - Asian Pac. J. Cancer Prev. VL - 14 IS - 11 N2 - BACKGROUND: Breast cancer is a major health problem worldwide. Olive oil induces apoptosis in some cancer cells due to phenolic compounds like oleuropein. Although oleuropein has anticancer activity, the underlying mechanisms of action remain unknown. The study aimed to assess the mechanism of oleuropin-induced breast cancer cell apoptosis. MATERIALS AND METHODS: p53, Bcl-2 and Bax gene expression was evaluated by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR) in luminal MCF-7 cells. RESULTS: Oleuropein-induced apoptosis was accompanied by up-regulation of both p53 and Bax gene expression levels and down-regulation in Bcl2. CONCLUSIONS: Oleuropein induces apoptosis in breast tumour cells via a p53-dependent pathway mediated by Bax and Bcl2 genes. Therefore, oleuropein may have therapeutic potential in breast cancer patients by inducing apoptosis via activation of the p53 pathway. SN - 2476-762X UR - https://www.unboundmedicine.com/medline/citation/24377598/Oleuropein_induces_apoptosis_via_the_p53_pathway_in_breast_cancer_cells_ L2 - http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:24377598&key=2014.14.11.6739 DB - PRIME DP - Unbound Medicine ER -