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Olmesartan medoxomil reverses left ventricle hypertrophy and reduces inflammatory cytokine IL-6 in the renovascular hypertensive rats.
Eur Rev Med Pharmacol Sci. 2013 Dec; 17(24):3318-22.ER

Abstract

AIM

To investigate the effects of Olmesartan Medoxomil (OM) on left ventricle hypertrophy (LVH) and inflammatory cytokines IL-6 and IL-10 levels in renovascular hypertensive rats.

MATERIALS AND METHODS

Qualified 30 male Wistar rats were randomly divided into three groups: sham-operation group (SO, n=10), model control group (MC, n=10), and Olmesartan Medoxomil group (OM, n=10). Renovascular hypertension was induced by ligating the abdominal aorta and 10 mg/kg OM was administered daily to the OM group by gastric perfusion for 7 weeks. The ratio of left ventricle mass to body weight (LVM/BW) was calculated as the index of cardiac hypertrophy, and the inflammatory cytokines IL-6 and IL-10 in serum and cardiac tissue were measured by ELISA assays.

RESULTS

The LVM/BW ratios in the MC group were about 50% higher than that in the SO group (p < 0.001). The OM group showed much reduced LVM/BW ratios compared with the MC group (p < 0.001) and were similar to that in the SO group (p > 0.05), indicating a complete reversal of the left ventricular hypertrophy caused by aorta ligation. The IL-6 and IL-10 levels in both the serum and cardiac tissue increased following aorta ligation (MC vs. SO, p < 0.001). While OM treatment significantly reduced IL-6 levels in the aorta-ligated rats (OM vs. MC, p < 0.001), IL-10 levels were not affected (OM vs. MC, p > 0.05).

CONCLUSIONS

OM completely reversed left ventricle hypertrophy and reduced IL-6 levels in renovascular hypertensive rats. Its effect on IL-10 levels in this animal model was not statistically significant.

Authors+Show Affiliations

The Municipal Hospital of Yantai City Government, China. jianpingwangng@hotmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24379062

Citation

Li, Z-C, et al. "Olmesartan Medoxomil Reverses Left Ventricle Hypertrophy and Reduces Inflammatory Cytokine IL-6 in the Renovascular Hypertensive Rats." European Review for Medical and Pharmacological Sciences, vol. 17, no. 24, 2013, pp. 3318-22.
Li ZC, Yu HY, Wang XX, et al. Olmesartan medoxomil reverses left ventricle hypertrophy and reduces inflammatory cytokine IL-6 in the renovascular hypertensive rats. Eur Rev Med Pharmacol Sci. 2013;17(24):3318-22.
Li, Z. C., Yu, H. Y., Wang, X. X., Zhang, M., & Wang, J. P. (2013). Olmesartan medoxomil reverses left ventricle hypertrophy and reduces inflammatory cytokine IL-6 in the renovascular hypertensive rats. European Review for Medical and Pharmacological Sciences, 17(24), 3318-22.
Li ZC, et al. Olmesartan Medoxomil Reverses Left Ventricle Hypertrophy and Reduces Inflammatory Cytokine IL-6 in the Renovascular Hypertensive Rats. Eur Rev Med Pharmacol Sci. 2013;17(24):3318-22. PubMed PMID: 24379062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Olmesartan medoxomil reverses left ventricle hypertrophy and reduces inflammatory cytokine IL-6 in the renovascular hypertensive rats. AU - Li,Z-C, AU - Yu,H-Y, AU - Wang,X-X, AU - Zhang,M, AU - Wang,J-P, PY - 2014/1/1/entrez PY - 2014/1/1/pubmed PY - 2014/3/29/medline SP - 3318 EP - 22 JF - European review for medical and pharmacological sciences JO - Eur Rev Med Pharmacol Sci VL - 17 IS - 24 N2 - AIM: To investigate the effects of Olmesartan Medoxomil (OM) on left ventricle hypertrophy (LVH) and inflammatory cytokines IL-6 and IL-10 levels in renovascular hypertensive rats. MATERIALS AND METHODS: Qualified 30 male Wistar rats were randomly divided into three groups: sham-operation group (SO, n=10), model control group (MC, n=10), and Olmesartan Medoxomil group (OM, n=10). Renovascular hypertension was induced by ligating the abdominal aorta and 10 mg/kg OM was administered daily to the OM group by gastric perfusion for 7 weeks. The ratio of left ventricle mass to body weight (LVM/BW) was calculated as the index of cardiac hypertrophy, and the inflammatory cytokines IL-6 and IL-10 in serum and cardiac tissue were measured by ELISA assays. RESULTS: The LVM/BW ratios in the MC group were about 50% higher than that in the SO group (p < 0.001). The OM group showed much reduced LVM/BW ratios compared with the MC group (p < 0.001) and were similar to that in the SO group (p > 0.05), indicating a complete reversal of the left ventricular hypertrophy caused by aorta ligation. The IL-6 and IL-10 levels in both the serum and cardiac tissue increased following aorta ligation (MC vs. SO, p < 0.001). While OM treatment significantly reduced IL-6 levels in the aorta-ligated rats (OM vs. MC, p < 0.001), IL-10 levels were not affected (OM vs. MC, p > 0.05). CONCLUSIONS: OM completely reversed left ventricle hypertrophy and reduced IL-6 levels in renovascular hypertensive rats. Its effect on IL-10 levels in this animal model was not statistically significant. SN - 1128-3602 UR - https://www.unboundmedicine.com/medline/citation/24379062/Olmesartan_medoxomil_reverses_left_ventricle_hypertrophy_and_reduces_inflammatory_cytokine_IL_6_in_the_renovascular_hypertensive_rats_ L2 - http://www.europeanreview.org/article/6178 DB - PRIME DP - Unbound Medicine ER -