Tags

Type your tag names separated by a space and hit enter

Psychometric hepatic encephalopathy score for diagnosis of minimal hepatic encephalopathy in China.

Abstract

AIM

To construct normal values for the tests of the psychometric hepatic encephalopathy score (PHES) and to evaluate its usefulness in the diagnosis of minimal hepatic encephalopathy (MHE) among Chinese individuals with cirrhosis.

METHODS

The five tests of PHES, number connection test-A (NCT-A), number connection test-B, serial dotting test, line tracing test and digit symbol test (DST), were administered to all enrolled subjects in a quiet room with sufficient light. Cirrhotic subjects with overt HE were excluded by the West-Haven criteria and a detailed neurological examination. Based on the nomograms of healthy volunteers, the patients were classified as having MHE when their PHES was less than -4.

RESULTS

In total, 146 healthy volunteers completed all the PHES tests. Age and education years were confirmed to be predictors of all five tests. In total, 53 patients with liver cirrhosis completed the PHES. Of the patients with liver cirrhosis, 24 (45.3%), 22(41.5%) and 7(13.2%) had Child-Pugh grades A, B and C, respectively. MHE was diagnosed in 26 patients (49.1%). Compared with compensated cirrhotic patients (Child A), decompensated cirrhotic patients (Child B and C) had a higher proportion of MHE (65.5% vs 29.2%). No differences in age and education years were found between the MHE and non-MHE groups. NCT-A and DST were able to diagnose MHE with a sensitivity of 76.9% and a specificity of 96.3% (AUC = 0.866, K = 0.735).

CONCLUSION

The proportion of MHE is associated with liver function. NCT-A and DST are simple tools that can be used for the diagnosis of MHE in China.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Su-Wen Li, Jian-Ming Xu, Anhui Geriatric Institute of Anhui Medical University, Hefei 230022, Anhui Province, China.

    ,

    Su-Wen Li, Jian-Ming Xu, Anhui Geriatric Institute of Anhui Medical University, Hefei 230022, Anhui Province, China.

    ,

    Su-Wen Li, Jian-Ming Xu, Anhui Geriatric Institute of Anhui Medical University, Hefei 230022, Anhui Province, China.

    ,

    Su-Wen Li, Jian-Ming Xu, Anhui Geriatric Institute of Anhui Medical University, Hefei 230022, Anhui Province, China.

    ,

    Su-Wen Li, Jian-Ming Xu, Anhui Geriatric Institute of Anhui Medical University, Hefei 230022, Anhui Province, China.

    Su-Wen Li, Jian-Ming Xu, Anhui Geriatric Institute of Anhui Medical University, Hefei 230022, Anhui Province, China.

    Source

    World journal of gastroenterology 19:46 2013 Dec 14 pg 8745-51

    MeSH

    Adult
    Aged
    Asian Continental Ancestry Group
    Case-Control Studies
    China
    Cognition
    Female
    Hepatic Encephalopathy
    Humans
    Liver Cirrhosis
    Liver Function Tests
    Male
    Middle Aged
    Neuropsychological Tests
    Predictive Value of Tests
    Psychometrics
    Reproducibility of Results
    Severity of Illness Index
    Young Adult

    Pub Type(s)

    Journal Article
    Validation Studies

    Language

    eng

    PubMed ID

    24379595

    Citation

    Li, Su-Wen, et al. "Psychometric Hepatic Encephalopathy Score for Diagnosis of Minimal Hepatic Encephalopathy in China." World Journal of Gastroenterology, vol. 19, no. 46, 2013, pp. 8745-51.
    Li SW, Wang K, Yu YQ, et al. Psychometric hepatic encephalopathy score for diagnosis of minimal hepatic encephalopathy in China. World J Gastroenterol. 2013;19(46):8745-51.
    Li, S. W., Wang, K., Yu, Y. Q., Wang, H. B., Li, Y. H., & Xu, J. M. (2013). Psychometric hepatic encephalopathy score for diagnosis of minimal hepatic encephalopathy in China. World Journal of Gastroenterology, 19(46), pp. 8745-51. doi:10.3748/wjg.v19.i46.8745.
    Li SW, et al. Psychometric Hepatic Encephalopathy Score for Diagnosis of Minimal Hepatic Encephalopathy in China. World J Gastroenterol. 2013 Dec 14;19(46):8745-51. PubMed PMID: 24379595.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Psychometric hepatic encephalopathy score for diagnosis of minimal hepatic encephalopathy in China. AU - Li,Su-Wen, AU - Wang,Kai, AU - Yu,Yong-Qiang, AU - Wang,Hai-Bao, AU - Li,Yuan-Hai, AU - Xu,Jian-Ming, PY - 2013/09/10/received PY - 2013/10/20/revised PY - 2013/11/01/accepted PY - 2014/1/1/entrez PY - 2014/1/1/pubmed PY - 2014/6/26/medline KW - Cirrhosis KW - Digit symbol test KW - Minimal hepatic encephalopathy KW - Neuropsychological tests KW - Number connection test KW - Psychometric hepatic encephalopathy score SP - 8745 EP - 51 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 19 IS - 46 N2 - AIM: To construct normal values for the tests of the psychometric hepatic encephalopathy score (PHES) and to evaluate its usefulness in the diagnosis of minimal hepatic encephalopathy (MHE) among Chinese individuals with cirrhosis. METHODS: The five tests of PHES, number connection test-A (NCT-A), number connection test-B, serial dotting test, line tracing test and digit symbol test (DST), were administered to all enrolled subjects in a quiet room with sufficient light. Cirrhotic subjects with overt HE were excluded by the West-Haven criteria and a detailed neurological examination. Based on the nomograms of healthy volunteers, the patients were classified as having MHE when their PHES was less than -4. RESULTS: In total, 146 healthy volunteers completed all the PHES tests. Age and education years were confirmed to be predictors of all five tests. In total, 53 patients with liver cirrhosis completed the PHES. Of the patients with liver cirrhosis, 24 (45.3%), 22(41.5%) and 7(13.2%) had Child-Pugh grades A, B and C, respectively. MHE was diagnosed in 26 patients (49.1%). Compared with compensated cirrhotic patients (Child A), decompensated cirrhotic patients (Child B and C) had a higher proportion of MHE (65.5% vs 29.2%). No differences in age and education years were found between the MHE and non-MHE groups. NCT-A and DST were able to diagnose MHE with a sensitivity of 76.9% and a specificity of 96.3% (AUC = 0.866, K = 0.735). CONCLUSION: The proportion of MHE is associated with liver function. NCT-A and DST are simple tools that can be used for the diagnosis of MHE in China. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/24379595/Psychometric_hepatic_encephalopathy_score_for_diagnosis_of_minimal_hepatic_encephalopathy_in_China_ L2 - http://www.wjgnet.com/1007-9327/full/v19/i46/8745.htm DB - PRIME DP - Unbound Medicine ER -