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Psychometric hepatic encephalopathy score for diagnosis of minimal hepatic encephalopathy in China.
World J Gastroenterol 2013; 19(46):8745-51WJ

Abstract

AIM

To construct normal values for the tests of the psychometric hepatic encephalopathy score (PHES) and to evaluate its usefulness in the diagnosis of minimal hepatic encephalopathy (MHE) among Chinese individuals with cirrhosis.

METHODS

The five tests of PHES, number connection test-A (NCT-A), number connection test-B, serial dotting test, line tracing test and digit symbol test (DST), were administered to all enrolled subjects in a quiet room with sufficient light. Cirrhotic subjects with overt HE were excluded by the West-Haven criteria and a detailed neurological examination. Based on the nomograms of healthy volunteers, the patients were classified as having MHE when their PHES was less than -4.

RESULTS

In total, 146 healthy volunteers completed all the PHES tests. Age and education years were confirmed to be predictors of all five tests. In total, 53 patients with liver cirrhosis completed the PHES. Of the patients with liver cirrhosis, 24 (45.3%), 22(41.5%) and 7(13.2%) had Child-Pugh grades A, B and C, respectively. MHE was diagnosed in 26 patients (49.1%). Compared with compensated cirrhotic patients (Child A), decompensated cirrhotic patients (Child B and C) had a higher proportion of MHE (65.5% vs 29.2%). No differences in age and education years were found between the MHE and non-MHE groups. NCT-A and DST were able to diagnose MHE with a sensitivity of 76.9% and a specificity of 96.3% (AUC = 0.866, K = 0.735).

CONCLUSION

The proportion of MHE is associated with liver function. NCT-A and DST are simple tools that can be used for the diagnosis of MHE in China.

Authors+Show Affiliations

Su-Wen Li, Jian-Ming Xu, Anhui Geriatric Institute of Anhui Medical University, Hefei 230022, Anhui Province, China.Su-Wen Li, Jian-Ming Xu, Anhui Geriatric Institute of Anhui Medical University, Hefei 230022, Anhui Province, China.Su-Wen Li, Jian-Ming Xu, Anhui Geriatric Institute of Anhui Medical University, Hefei 230022, Anhui Province, China.Su-Wen Li, Jian-Ming Xu, Anhui Geriatric Institute of Anhui Medical University, Hefei 230022, Anhui Province, China.Su-Wen Li, Jian-Ming Xu, Anhui Geriatric Institute of Anhui Medical University, Hefei 230022, Anhui Province, China.Su-Wen Li, Jian-Ming Xu, Anhui Geriatric Institute of Anhui Medical University, Hefei 230022, Anhui Province, China.

Pub Type(s)

Journal Article
Validation Studies

Language

eng

PubMed ID

24379595

Citation

Li, Su-Wen, et al. "Psychometric Hepatic Encephalopathy Score for Diagnosis of Minimal Hepatic Encephalopathy in China." World Journal of Gastroenterology, vol. 19, no. 46, 2013, pp. 8745-51.
Li SW, Wang K, Yu YQ, et al. Psychometric hepatic encephalopathy score for diagnosis of minimal hepatic encephalopathy in China. World J Gastroenterol. 2013;19(46):8745-51.
Li, S. W., Wang, K., Yu, Y. Q., Wang, H. B., Li, Y. H., & Xu, J. M. (2013). Psychometric hepatic encephalopathy score for diagnosis of minimal hepatic encephalopathy in China. World Journal of Gastroenterology, 19(46), pp. 8745-51. doi:10.3748/wjg.v19.i46.8745.
Li SW, et al. Psychometric Hepatic Encephalopathy Score for Diagnosis of Minimal Hepatic Encephalopathy in China. World J Gastroenterol. 2013 Dec 14;19(46):8745-51. PubMed PMID: 24379595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Psychometric hepatic encephalopathy score for diagnosis of minimal hepatic encephalopathy in China. AU - Li,Su-Wen, AU - Wang,Kai, AU - Yu,Yong-Qiang, AU - Wang,Hai-Bao, AU - Li,Yuan-Hai, AU - Xu,Jian-Ming, PY - 2013/09/10/received PY - 2013/10/20/revised PY - 2013/11/01/accepted PY - 2014/1/1/entrez PY - 2014/1/1/pubmed PY - 2014/6/26/medline KW - Cirrhosis KW - Digit symbol test KW - Minimal hepatic encephalopathy KW - Neuropsychological tests KW - Number connection test KW - Psychometric hepatic encephalopathy score SP - 8745 EP - 51 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 19 IS - 46 N2 - AIM: To construct normal values for the tests of the psychometric hepatic encephalopathy score (PHES) and to evaluate its usefulness in the diagnosis of minimal hepatic encephalopathy (MHE) among Chinese individuals with cirrhosis. METHODS: The five tests of PHES, number connection test-A (NCT-A), number connection test-B, serial dotting test, line tracing test and digit symbol test (DST), were administered to all enrolled subjects in a quiet room with sufficient light. Cirrhotic subjects with overt HE were excluded by the West-Haven criteria and a detailed neurological examination. Based on the nomograms of healthy volunteers, the patients were classified as having MHE when their PHES was less than -4. RESULTS: In total, 146 healthy volunteers completed all the PHES tests. Age and education years were confirmed to be predictors of all five tests. In total, 53 patients with liver cirrhosis completed the PHES. Of the patients with liver cirrhosis, 24 (45.3%), 22(41.5%) and 7(13.2%) had Child-Pugh grades A, B and C, respectively. MHE was diagnosed in 26 patients (49.1%). Compared with compensated cirrhotic patients (Child A), decompensated cirrhotic patients (Child B and C) had a higher proportion of MHE (65.5% vs 29.2%). No differences in age and education years were found between the MHE and non-MHE groups. NCT-A and DST were able to diagnose MHE with a sensitivity of 76.9% and a specificity of 96.3% (AUC = 0.866, K = 0.735). CONCLUSION: The proportion of MHE is associated with liver function. NCT-A and DST are simple tools that can be used for the diagnosis of MHE in China. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/24379595/Psychometric_hepatic_encephalopathy_score_for_diagnosis_of_minimal_hepatic_encephalopathy_in_China_ L2 - http://www.wjgnet.com/1007-9327/full/v19/i46/8745.htm DB - PRIME DP - Unbound Medicine ER -