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A study of micronized poloxamers as lubricants in direct compression of tablets.
Acta Pol Pharm. 2013 Nov-Dec; 70(6):1087-96.AP

Abstract

The study evaluates the micronized poloxamers Lptrol micro127 (poloxamer 407) and Lptrol micro 68 (poloxamer 188) as lubricants in combination with the dry binders microcrystalline cellulose and spray-dried lactose. Magnesium stearate was employed as the comparative lubricant. The parameters under study included energy for friction, plasticity, ejection force, tensile strength of tablets, and disintegration time of tablets. The factors of influence were the concentration of lubricants, compression force, and mixing parameters. The lubricating effect of micronized poloxamers was smaller than that of magnesium stearate. Higher concentrations of poloxamers decreased the tensile strength of tablets from microcrystalline cellulose, shortened the disintegration time, and slightly prolonged the disintegration time in the case of spray-dried lactose. Parameters of mixing of dry binders with poloxamers influenced the tested parameters of compression more in the case of spray-dried lactose. In microcrystalline cellulose, they influenced more the tensile strength and disintegration time of tablets.

Authors+Show Affiliations

Muzíková J
Department of Pharmaceutical Technology, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. muzikova@faf.cuni.cz
Vyhlídalová B
Department of Pharmaceutical Technology, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.
Pekárek T
Zentiva, k.s., Prague, Czech Republic.

MeSH

CelluloseChemistry, PharmaceuticalExcipientsFrictionLactoseLubricantsPoloxamerSolubilityStearic AcidsTabletsTechnology, PharmaceuticalTensile StrengthTime Factors

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24383332

Citation

Muzíková, Jitka, et al. "A Study of Micronized Poloxamers as Lubricants in Direct Compression of Tablets." Acta Poloniae Pharmaceutica, vol. 70, no. 6, 2013, pp. 1087-96.
Muzíková J, Vyhlídalová B, Pekárek T. A study of micronized poloxamers as lubricants in direct compression of tablets. Acta Pol Pharm. 2013;70(6):1087-96.
Muzíková, J., Vyhlídalová, B., & Pekárek, T. (2013). A study of micronized poloxamers as lubricants in direct compression of tablets. Acta Poloniae Pharmaceutica, 70(6), 1087-96.
Muzíková J, Vyhlídalová B, Pekárek T. A Study of Micronized Poloxamers as Lubricants in Direct Compression of Tablets. Acta Pol Pharm. 2013 Nov-Dec;70(6):1087-96. PubMed PMID: 24383332.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A study of micronized poloxamers as lubricants in direct compression of tablets. AU - Muzíková,Jitka, AU - Vyhlídalová,Barbora, AU - Pekárek,Tomás, PY - 2014/1/4/entrez PY - 2014/1/5/pubmed PY - 2014/2/12/medline SP - 1087 EP - 96 JF - Acta poloniae pharmaceutica JO - Acta Pol Pharm VL - 70 IS - 6 N2 - The study evaluates the micronized poloxamers Lptrol micro127 (poloxamer 407) and Lptrol micro 68 (poloxamer 188) as lubricants in combination with the dry binders microcrystalline cellulose and spray-dried lactose. Magnesium stearate was employed as the comparative lubricant. The parameters under study included energy for friction, plasticity, ejection force, tensile strength of tablets, and disintegration time of tablets. The factors of influence were the concentration of lubricants, compression force, and mixing parameters. The lubricating effect of micronized poloxamers was smaller than that of magnesium stearate. Higher concentrations of poloxamers decreased the tensile strength of tablets from microcrystalline cellulose, shortened the disintegration time, and slightly prolonged the disintegration time in the case of spray-dried lactose. Parameters of mixing of dry binders with poloxamers influenced the tested parameters of compression more in the case of spray-dried lactose. In microcrystalline cellulose, they influenced more the tensile strength and disintegration time of tablets. SN - 0001-6837 UR - https://www.unboundmedicine.com/medline/citation/24383332/A_study_of_micronized_poloxamers_as_lubricants_in_direct_compression_of_tablets_ DB - PRIME DP - Unbound Medicine ER -