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Modulatory effects of morin on hyperglycemia by attenuating the hepatic key enzymes of carbohydrate metabolism and β-cell function in streptozotocin-induced diabetic rats.
Environ Toxicol Pharmacol. 2014 Jan; 37(1):326-35.ET

Abstract

The present study was aimed to evaluate the effect of morin on blood glucose, insulin level, hepatic glucose regulating enzyme activities and glycogen level in experimental diabetes. Diabetes mellitus was induced by a single intraperitoneal injection of streptozotocin (STZ) (50 mg/kg b.w.). Five days after STZ injection, diabetic rats received morin (25 and 50 mg/kg b.w.) orally for 30 days. Glibenclamide was used as reference drug. Morin treatment significantly reduced the blood glucose and improved the serum insulin levels. Further, a dose-dependent reduction in glucose-6-phosphatase and fructose-1,6-bisphosphatase was observed along with the increase in liver hexokinase and glucose-6-phosphate dehydrogenase activities. Morin supplement were found to be effective in preserving the normal histological appearance of pancreatic islets as well as to preserve insulin-positive β-cells in STZ-rats. Therefore, these findings suggest that morin displays beneficial effects in the treatment of diabetes, mediated through the regulation of carbohydrate metabolic enzyme activities.

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Authors+Show Affiliations

Vanitha P
Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603 203, Tamilnadu, India.
Uma C
Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603 203, Tamilnadu, India.
Suganya N
Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603 203, Tamilnadu, India.
Bhakkiyalakshmi E
Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603 203, Tamilnadu, India.
Suriyanarayanan S
Department of Water and Health, JSS University, Mysore 570 015, Karnataka, India.
Gunasekaran P
The King Institute of Preventive Medicine and Research, Guindy, Chennai 600 032, Tamilnadu, India.
Sivasubramanian S
The King Institute of Preventive Medicine and Research, Guindy, Chennai 600 032, Tamilnadu, India.
Ramkumar KM
SRM Research Institute, SRM University, Kattankulathur 603 203, Tamilnadu, India. Electronic address: ramkumar.km@res.srmuniv.ac.in.

MeSH

AnimalsBlood GlucoseCarbohydrate MetabolismDiabetes Mellitus, ExperimentalFlavonoidsGlycogenHyperglycemiaHypoglycemic AgentsInsulinInsulin-Secreting CellsLiverMalePancreasRatsRats, Wistar

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24384280

Citation

Vanitha, P, et al. "Modulatory Effects of Morin On Hyperglycemia By Attenuating the Hepatic Key Enzymes of Carbohydrate Metabolism and Β-cell Function in Streptozotocin-induced Diabetic Rats." Environmental Toxicology and Pharmacology, vol. 37, no. 1, 2014, pp. 326-35.
Vanitha P, Uma C, Suganya N, et al. Modulatory effects of morin on hyperglycemia by attenuating the hepatic key enzymes of carbohydrate metabolism and β-cell function in streptozotocin-induced diabetic rats. Environ Toxicol Pharmacol. 2014;37(1):326-35.
Vanitha, P., Uma, C., Suganya, N., Bhakkiyalakshmi, E., Suriyanarayanan, S., Gunasekaran, P., Sivasubramanian, S., & Ramkumar, K. M. (2014). Modulatory effects of morin on hyperglycemia by attenuating the hepatic key enzymes of carbohydrate metabolism and β-cell function in streptozotocin-induced diabetic rats. Environmental Toxicology and Pharmacology, 37(1), 326-35. https://doi.org/10.1016/j.etap.2013.11.017
Vanitha P, et al. Modulatory Effects of Morin On Hyperglycemia By Attenuating the Hepatic Key Enzymes of Carbohydrate Metabolism and Β-cell Function in Streptozotocin-induced Diabetic Rats. Environ Toxicol Pharmacol. 2014;37(1):326-35. PubMed PMID: 24384280.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulatory effects of morin on hyperglycemia by attenuating the hepatic key enzymes of carbohydrate metabolism and β-cell function in streptozotocin-induced diabetic rats. AU - Vanitha,P, AU - Uma,C, AU - Suganya,N, AU - Bhakkiyalakshmi,E, AU - Suriyanarayanan,S, AU - Gunasekaran,P, AU - Sivasubramanian,S, AU - Ramkumar,K M, Y1 - 2013/12/09/ PY - 2013/08/23/received PY - 2013/11/18/revised PY - 2013/11/19/accepted PY - 2014/1/4/entrez PY - 2014/1/5/pubmed PY - 2014/10/29/medline KW - Antidiabetic activity KW - Carbohydrate enzymes KW - Morin KW - Natural products KW - STZ SP - 326 EP - 35 JF - Environmental toxicology and pharmacology JO - Environ Toxicol Pharmacol VL - 37 IS - 1 N2 - The present study was aimed to evaluate the effect of morin on blood glucose, insulin level, hepatic glucose regulating enzyme activities and glycogen level in experimental diabetes. Diabetes mellitus was induced by a single intraperitoneal injection of streptozotocin (STZ) (50 mg/kg b.w.). Five days after STZ injection, diabetic rats received morin (25 and 50 mg/kg b.w.) orally for 30 days. Glibenclamide was used as reference drug. Morin treatment significantly reduced the blood glucose and improved the serum insulin levels. Further, a dose-dependent reduction in glucose-6-phosphatase and fructose-1,6-bisphosphatase was observed along with the increase in liver hexokinase and glucose-6-phosphate dehydrogenase activities. Morin supplement were found to be effective in preserving the normal histological appearance of pancreatic islets as well as to preserve insulin-positive β-cells in STZ-rats. Therefore, these findings suggest that morin displays beneficial effects in the treatment of diabetes, mediated through the regulation of carbohydrate metabolic enzyme activities. SN - 1872-7077 UR - https://www.unboundmedicine.com/medline/citation/24384280/Modulatory_effects_of_morin_on_hyperglycemia_by_attenuating_the_hepatic_key_enzymes_of_carbohydrate_metabolism_and_β_cell_function_in_streptozotocin_induced_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1382-6689(13)00258-5 DB - PRIME DP - Unbound Medicine ER -
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