Tags

Type your tag names separated by a space and hit enter

Hepatitis E: An emerging infection in high income countries.
J Clin Virol. 2014 Feb; 59(2):81-8.JC

Abstract

Hepatitis E virus (HEV) genotype 3 is the most recently characterized hepatotropic virus and is increasingly being recognized as the cause of unexplained liver disease in many western countries. Although asymptomatic in most cases, HEV GT3 may be responsible for a wide range of illnesses, from mild to fulminant acute hepatitis, and also chronic hepatitis in immunocompromised patients. Extrahepatic manifestations have been occasionally described. Anti-HEV antibody detection by immunoassays is hampered by moderate test accuracy particularly in immunocompromised hosts while a WHO international standard for molecular detection of HEV RNA by RT-PCR has recently been introduced. This review describes the basic virology, epidemiology, clinical virology and treatment of HEV GT3 infections in high income countries.

Authors+Show Affiliations

Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht (UMCU), Utrecht, The Netherlands; Members of the European Study Group on Viral Hepatitis (ESGVH) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Switzerland. Electronic address: j.e.arends@umcutrecht.nl.Microbiology & Virology Laboratory, Department of Infectious Diseases, Amedeo di Savoia Hospital, Turin, Italy; Members of the European Study Group on Viral Hepatitis (ESGVH) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Switzerland.Faculty of Medicine & Health Sciences, NIHR Nottingham Digestive Diseases Biomedical Research Unit, Queen's Medical Centre, Nottingham, United Kingdom; Members of the European Study Group on Viral Hepatitis (ESGVH) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Switzerland.Peninsula College of Medicine and Dentistry, Royal Cornwall Hospital Trust, Truro, United Kingdom.Centre de Physiopathologie de Toulouse-Purpan, Université Paul Sabatier, Toulouse, France.Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht (UMCU), Utrecht, The Netherlands; Members of the European Study Group on Viral Hepatitis (ESGVH) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Switzerland.Department of Infectious Diseases, Hôpital Cochin, Paris, France; Members of the European Study Group on Viral Hepatitis (ESGVH) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Switzerland.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24388207

Citation

Arends, J E., et al. "Hepatitis E: an Emerging Infection in High Income Countries." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 59, no. 2, 2014, pp. 81-8.
Arends JE, Ghisetti V, Irving W, et al. Hepatitis E: An emerging infection in high income countries. J Clin Virol. 2014;59(2):81-8.
Arends, J. E., Ghisetti, V., Irving, W., Dalton, H. R., Izopet, J., Hoepelman, A. I., & Salmon, D. (2014). Hepatitis E: An emerging infection in high income countries. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 59(2), 81-8. https://doi.org/10.1016/j.jcv.2013.11.013
Arends JE, et al. Hepatitis E: an Emerging Infection in High Income Countries. J Clin Virol. 2014;59(2):81-8. PubMed PMID: 24388207.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis E: An emerging infection in high income countries. AU - Arends,J E, AU - Ghisetti,V, AU - Irving,W, AU - Dalton,H R, AU - Izopet,J, AU - Hoepelman,A I M, AU - Salmon,D, Y1 - 2013/12/11/ PY - 2012/12/21/received PY - 2013/11/11/revised PY - 2013/11/25/accepted PY - 2014/1/7/entrez PY - 2014/1/7/pubmed PY - 2014/9/18/medline KW - Genotype 3 KW - Hepatitis E KW - Ribavirin, Autochthonous transmission SP - 81 EP - 8 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 59 IS - 2 N2 - Hepatitis E virus (HEV) genotype 3 is the most recently characterized hepatotropic virus and is increasingly being recognized as the cause of unexplained liver disease in many western countries. Although asymptomatic in most cases, HEV GT3 may be responsible for a wide range of illnesses, from mild to fulminant acute hepatitis, and also chronic hepatitis in immunocompromised patients. Extrahepatic manifestations have been occasionally described. Anti-HEV antibody detection by immunoassays is hampered by moderate test accuracy particularly in immunocompromised hosts while a WHO international standard for molecular detection of HEV RNA by RT-PCR has recently been introduced. This review describes the basic virology, epidemiology, clinical virology and treatment of HEV GT3 infections in high income countries. SN - 1873-5967 UR - https://www.unboundmedicine.com/medline/citation/24388207/Hepatitis_E:_An_emerging_infection_in_high_income_countries_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(13)00509-X DB - PRIME DP - Unbound Medicine ER -