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Alpha-amylase and alpha-glucosidase inhibition is differentially modulated by fucoidan obtained from Fucus vesiculosus and Ascophyllum nodosum.
Phytochemistry 2014; 98:27-33P

Abstract

Fucoidan is a water-soluble, negatively charged, biologically active polysaccharide found in great abundance in brown marine algae. However, the inhibition of α-amylase and α-glucosidase by fucoidan derived from two algal species (Ascophyllum nodosum and Fucus vesiculosus) harvested at different periods (accounting for seasonal and yearly variations) has never been investigated. It was found that fucoidans inhibited α-glucosidase differently, depending on the algal species from which it was extracted and the algae's season of harvest. Fucoidan extracted from A. nodosum was a more potent inhibitor of α-glucosidase, with an IC50 ranging from 0.013 to 0.047 mg/mL, than the inhibition by fucoidan extracted from F. vesiculosus (IC50=0.049 mg/mL). In contrast, fucoidan extracted from F. vesiculosus did not inhibit α-amylase activity, while fucoidan from A. nodosum decreased α-amylase activity by 7-100% at 5 mg/mL depending upon the algae harvest period. An IC50 of 0.12-4.64 mg/mL for fucoidan from A. nodosum was found for the α-amylase inhibition. The ability of fucoidan to inhibit α-amylase and α-glucosidase thus varies according to the algae species and harvest period. A. nodosum is more suitable than F. vesiculosus as a source of fucoidan to inhibit α-amylase and α-glucosidase activities. Their potential benefits towards Type 2 diabetes management should be further investigated.

Authors+Show Affiliations

Department of Food Science and Nutrition, Institute of Nutrition and Functional Food, Pavillon Paul-Comtois, Laval University, 2425, rue de l'Agriculture, Quebec City, Qc, G1V 0A6, Canada.Department of Food Science and Nutrition, Institute of Nutrition and Functional Food, Pavillon Paul-Comtois, Laval University, 2425, rue de l'Agriculture, Quebec City, Qc, G1V 0A6, Canada.Department of Food Science and Nutrition, Institute of Nutrition and Functional Food, Pavillon Paul-Comtois, Laval University, 2425, rue de l'Agriculture, Quebec City, Qc, G1V 0A6, Canada. Electronic address: sylvie.turgeon@fsaa.ulaval.ca.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24388677

Citation

Kim, Kyung-Tae, et al. "Alpha-amylase and Alpha-glucosidase Inhibition Is Differentially Modulated By Fucoidan Obtained From Fucus Vesiculosus and Ascophyllum Nodosum." Phytochemistry, vol. 98, 2014, pp. 27-33.
Kim KT, Rioux LE, Turgeon SL. Alpha-amylase and alpha-glucosidase inhibition is differentially modulated by fucoidan obtained from Fucus vesiculosus and Ascophyllum nodosum. Phytochemistry. 2014;98:27-33.
Kim, K. T., Rioux, L. E., & Turgeon, S. L. (2014). Alpha-amylase and alpha-glucosidase inhibition is differentially modulated by fucoidan obtained from Fucus vesiculosus and Ascophyllum nodosum. Phytochemistry, 98, pp. 27-33. doi:10.1016/j.phytochem.2013.12.003.
Kim KT, Rioux LE, Turgeon SL. Alpha-amylase and Alpha-glucosidase Inhibition Is Differentially Modulated By Fucoidan Obtained From Fucus Vesiculosus and Ascophyllum Nodosum. Phytochemistry. 2014;98:27-33. PubMed PMID: 24388677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alpha-amylase and alpha-glucosidase inhibition is differentially modulated by fucoidan obtained from Fucus vesiculosus and Ascophyllum nodosum. AU - Kim,Kyung-Tae, AU - Rioux,Laurie-Eve, AU - Turgeon,Sylvie L, Y1 - 2013/12/30/ PY - 2011/10/31/received PY - 2012/06/30/revised PY - 2013/12/03/accepted PY - 2014/1/7/entrez PY - 2014/1/7/pubmed PY - 2014/12/15/medline KW - Ascophyllum nodosum KW - Brown seaweed KW - Enzyme inhibition KW - Fucoidan KW - Fucus vesiculosus KW - Harvest season KW - Sulfated fucan KW - Type 2 diabetes KW - α-Amylase KW - α-Glucosidase SP - 27 EP - 33 JF - Phytochemistry JO - Phytochemistry VL - 98 N2 - Fucoidan is a water-soluble, negatively charged, biologically active polysaccharide found in great abundance in brown marine algae. However, the inhibition of α-amylase and α-glucosidase by fucoidan derived from two algal species (Ascophyllum nodosum and Fucus vesiculosus) harvested at different periods (accounting for seasonal and yearly variations) has never been investigated. It was found that fucoidans inhibited α-glucosidase differently, depending on the algal species from which it was extracted and the algae's season of harvest. Fucoidan extracted from A. nodosum was a more potent inhibitor of α-glucosidase, with an IC50 ranging from 0.013 to 0.047 mg/mL, than the inhibition by fucoidan extracted from F. vesiculosus (IC50=0.049 mg/mL). In contrast, fucoidan extracted from F. vesiculosus did not inhibit α-amylase activity, while fucoidan from A. nodosum decreased α-amylase activity by 7-100% at 5 mg/mL depending upon the algae harvest period. An IC50 of 0.12-4.64 mg/mL for fucoidan from A. nodosum was found for the α-amylase inhibition. The ability of fucoidan to inhibit α-amylase and α-glucosidase thus varies according to the algae species and harvest period. A. nodosum is more suitable than F. vesiculosus as a source of fucoidan to inhibit α-amylase and α-glucosidase activities. Their potential benefits towards Type 2 diabetes management should be further investigated. SN - 1873-3700 UR - https://www.unboundmedicine.com/medline/citation/24388677/Alpha_amylase_and_alpha_glucosidase_inhibition_is_differentially_modulated_by_fucoidan_obtained_from_Fucus_vesiculosus_and_Ascophyllum_nodosum_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9422(13)00480-9 DB - PRIME DP - Unbound Medicine ER -