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Evaluation of the validity of the different arms of the ASAS set of criteria for axial spondyloarthritis and description of the different imaging abnormalities suggestive of spondyloarthritis: data from the DESIR cohort.
Ann Rheum Dis 2015; 74(4):746-51AR

Abstract

BACKGROUND

The Assessment of Spondyloarthritis International Society (ASAS) criteria for axial spondyloarthritis (SpA) allows classification of patients with ('imaging' arm) and without ('clinical' arm) imaging abnormalities of the sacroiliac joints.

OBJECTIVE

To compare the phenotype of early axial SpA with regard to the two arms of the ASAS axial SpA criteria.

METHODS

Demographics, clinical and biological features of SpA, disease activity, severity parameters, and imaging abnormalities at the sacroiliac and spine levels were compared, in the two arms of the ASAS axial SpA criteria, in the patients of the French cohort of early SpA.

RESULTS

Of the 615 patients analysed, 435 (70.7%) met the ASAS criteria (262 (60.2%) and 173 (39.8%) in the imaging and clinical arms, respectively). There were no major differences in the characteristics of the two groups except that those in the imaging arm were more likely to be younger, male and have higher concentrations of C-reactive protein. Imaging abnormalities other than those meeting the ASAS criteria for the imaging arm (ie, x-ray-determined structural damage or MRI-revealed inflammatory changes in the sacroiliac joint (SIJ)) were observed (MRI-SIJ structural damage (55.0% vs 3.5%), MRI-spine inflammatory changes (35.1% vs 12.9%), MRI-spine structural damage (10.3% vs 5.3%) and x-ray-syndesmophytes (11.8% vs 5.3%)) in the imaging versus clinical arm, respectively.

CONCLUSIONS

Our study confirms the external validity of the clinical arm of the ASAS criteria. It is notable that many patients in the clinical arm showed other imaging changes in SIJs and spine.

Authors+Show Affiliations

Paris Descartes University, Department of Rheumatology, Hôpital Cochin - Assistance Publique- Hôpitaux de Paris, INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité, France Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain.Paris Descartes University, Department of Rheumatology, Hôpital Cochin - Assistance Publique- Hôpitaux de Paris, INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité, France.Leiden University Medical Center, Leiden, The Netherlands.Laboratoire d'Investigation Clinique (LIC) EA4393, Université Paris Est Créteil, Créteil, France Service de Rhumatologie, AP-HP, Hôpital Henri-Mondor, Créteil, France.Endokrinologikum Berlin, Berlin, Germany.Paris Descartes University, Department of Rheumatology, Hôpital Cochin - Assistance Publique- Hôpitaux de Paris, INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité, France.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

24389295

Citation

Moltó, Anna, et al. "Evaluation of the Validity of the Different Arms of the ASAS Set of Criteria for Axial Spondyloarthritis and Description of the Different Imaging Abnormalities Suggestive of Spondyloarthritis: Data From the DESIR Cohort." Annals of the Rheumatic Diseases, vol. 74, no. 4, 2015, pp. 746-51.
Moltó A, Paternotte S, van der Heijde D, et al. Evaluation of the validity of the different arms of the ASAS set of criteria for axial spondyloarthritis and description of the different imaging abnormalities suggestive of spondyloarthritis: data from the DESIR cohort. Ann Rheum Dis. 2015;74(4):746-51.
Moltó, A., Paternotte, S., van der Heijde, D., Claudepierre, P., Rudwaleit, M., & Dougados, M. (2015). Evaluation of the validity of the different arms of the ASAS set of criteria for axial spondyloarthritis and description of the different imaging abnormalities suggestive of spondyloarthritis: data from the DESIR cohort. Annals of the Rheumatic Diseases, 74(4), pp. 746-51. doi:10.1136/annrheumdis-2013-204262.
Moltó A, et al. Evaluation of the Validity of the Different Arms of the ASAS Set of Criteria for Axial Spondyloarthritis and Description of the Different Imaging Abnormalities Suggestive of Spondyloarthritis: Data From the DESIR Cohort. Ann Rheum Dis. 2015;74(4):746-51. PubMed PMID: 24389295.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the validity of the different arms of the ASAS set of criteria for axial spondyloarthritis and description of the different imaging abnormalities suggestive of spondyloarthritis: data from the DESIR cohort. AU - Moltó,Anna, AU - Paternotte,Simon, AU - van der Heijde,Désirée, AU - Claudepierre,Pascal, AU - Rudwaleit,Martin, AU - Dougados,Maxime, Y1 - 2014/01/03/ PY - 2014/1/7/entrez PY - 2014/1/7/pubmed PY - 2015/5/29/medline KW - Ankylosing Spondylitis KW - Magnetic Resonance Imaging KW - Radiography SP - 746 EP - 51 JF - Annals of the rheumatic diseases JO - Ann. Rheum. Dis. VL - 74 IS - 4 N2 - BACKGROUND: The Assessment of Spondyloarthritis International Society (ASAS) criteria for axial spondyloarthritis (SpA) allows classification of patients with ('imaging' arm) and without ('clinical' arm) imaging abnormalities of the sacroiliac joints. OBJECTIVE: To compare the phenotype of early axial SpA with regard to the two arms of the ASAS axial SpA criteria. METHODS: Demographics, clinical and biological features of SpA, disease activity, severity parameters, and imaging abnormalities at the sacroiliac and spine levels were compared, in the two arms of the ASAS axial SpA criteria, in the patients of the French cohort of early SpA. RESULTS: Of the 615 patients analysed, 435 (70.7%) met the ASAS criteria (262 (60.2%) and 173 (39.8%) in the imaging and clinical arms, respectively). There were no major differences in the characteristics of the two groups except that those in the imaging arm were more likely to be younger, male and have higher concentrations of C-reactive protein. Imaging abnormalities other than those meeting the ASAS criteria for the imaging arm (ie, x-ray-determined structural damage or MRI-revealed inflammatory changes in the sacroiliac joint (SIJ)) were observed (MRI-SIJ structural damage (55.0% vs 3.5%), MRI-spine inflammatory changes (35.1% vs 12.9%), MRI-spine structural damage (10.3% vs 5.3%) and x-ray-syndesmophytes (11.8% vs 5.3%)) in the imaging versus clinical arm, respectively. CONCLUSIONS: Our study confirms the external validity of the clinical arm of the ASAS criteria. It is notable that many patients in the clinical arm showed other imaging changes in SIJs and spine. SN - 1468-2060 UR - https://www.unboundmedicine.com/medline/citation/24389295/Evaluation_of_the_validity_of_the_different_arms_of_the_ASAS_set_of_criteria_for_axial_spondyloarthritis_and_description_of_the_different_imaging_abnormalities_suggestive_of_spondyloarthritis:_data_from_the_DESIR_cohort_ L2 - https://ard.bmj.com/cgi/pmidlookup?view=long&pmid=24389295 DB - PRIME DP - Unbound Medicine ER -