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Effect of an antihistamine/decongestant on nasal and eustachian tube function following intranasal pollen challenge.
Ann Allergy. 1987 Jun; 58(6):442-6.AA

Abstract

Ten adult subjects with documented ragweed allergic rhinitis underwent progressive intranasal allergen challenge following pretreatment with either an antihistamine/decongestant or placebo in a double-blind crossover fashion. Objective measurements of nasal and Eustachian tube (ET) function were made following each challenge dose using posterior rhinomanometry and sonotubometry. The percent decrease in nasal airway function, expressed as a change in conductance, was significantly less in the drug pretreatment tests when compared with placebo pretreatment. Eustachian tube function was also significantly improved by antihistamine/decongestant pretreatment as 13 of the 20 ET were obstructed at a higher antigen dose following drug pretreatment when compared with placebo. These results demonstrate a role for antihistamine/decongestant preparations in the treatment of allergic rhinitis as well as for potential allergen-induced ET dysfunction.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2438966

Citation

Stillwagon, P K., et al. "Effect of an Antihistamine/decongestant On Nasal and Eustachian Tube Function Following Intranasal Pollen Challenge." Annals of Allergy, vol. 58, no. 6, 1987, pp. 442-6.
Stillwagon PK, Doyle WJ, Fireman P. Effect of an antihistamine/decongestant on nasal and eustachian tube function following intranasal pollen challenge. Ann Allergy. 1987;58(6):442-6.
Stillwagon, P. K., Doyle, W. J., & Fireman, P. (1987). Effect of an antihistamine/decongestant on nasal and eustachian tube function following intranasal pollen challenge. Annals of Allergy, 58(6), 442-6.
Stillwagon PK, Doyle WJ, Fireman P. Effect of an Antihistamine/decongestant On Nasal and Eustachian Tube Function Following Intranasal Pollen Challenge. Ann Allergy. 1987;58(6):442-6. PubMed PMID: 2438966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of an antihistamine/decongestant on nasal and eustachian tube function following intranasal pollen challenge. AU - Stillwagon,P K, AU - Doyle,W J, AU - Fireman,P, PY - 1987/6/1/pubmed PY - 1987/6/1/medline PY - 1987/6/1/entrez SP - 442 EP - 6 JF - Annals of allergy JO - Ann Allergy VL - 58 IS - 6 N2 - Ten adult subjects with documented ragweed allergic rhinitis underwent progressive intranasal allergen challenge following pretreatment with either an antihistamine/decongestant or placebo in a double-blind crossover fashion. Objective measurements of nasal and Eustachian tube (ET) function were made following each challenge dose using posterior rhinomanometry and sonotubometry. The percent decrease in nasal airway function, expressed as a change in conductance, was significantly less in the drug pretreatment tests when compared with placebo pretreatment. Eustachian tube function was also significantly improved by antihistamine/decongestant pretreatment as 13 of the 20 ET were obstructed at a higher antigen dose following drug pretreatment when compared with placebo. These results demonstrate a role for antihistamine/decongestant preparations in the treatment of allergic rhinitis as well as for potential allergen-induced ET dysfunction. SN - 0003-4738 UR - https://www.unboundmedicine.com/medline/citation/2438966/Effect_of_an_antihistamine/decongestant_on_nasal_and_eustachian_tube_function_following_intranasal_pollen_challenge_ L2 - https://medlineplus.gov/coldandcoughmedicines.html DB - PRIME DP - Unbound Medicine ER -