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Prevalence of human rhinovirus in children admitted to hospital with acute lower respiratory tract infections in Changsha, China.
J Med Virol. 2014 Nov; 86(11):1983-9.JM

Abstract

Human rhinovirus (HRV) is a causative agent of acute respiratory tract infections. This study analyzed the prevalence and clinical characteristics of three HRV groups (HRV-A, -B, and -C) among 1,165 children aged 14 years or younger who were hospitalized with acute lower respiratory tract infection in China. PCR or reverse transcription-PCR was performed to detect 14 respiratory viruses in nasopharyngeal aspirates collected from September 2007 to August 2008 in Changsha, China. HRV was detected in 202 (17.3%) of the 1,165 children; 25.3% of the HRV-positive children were 13-36 months of age (χ(2) = 22.803, P = 0.000). HRV was detected year round and peaked between September and December. Fifty-three percent of the HRV-positive samples were also positive for other respiratory viruses; respiratory syncytial virus (RSV) was the most common secondary virus. Phylogenetic analysis using the VP4/VP2 region grouped the HRV-positive strains as follows: 101 HRV-A (50.0%), 21 HRV-B (10.4%), and 80 HRV-C (39.6%). HRV-A infections occurred predominantly in spring and autumn, and the peak prevalence of HRV-C was in early winter and late autumn. HRV-B infections were less common in spring (χ(2) = 31.914, P = 0.000). No significant difference in clinical severity or presentation was found between patients with HRV single infection and HRV co-detections. Furthermore, the clinical characterizations did not differ among the three HRV species. These results suggest that HRV-C is an important viral agent along with HRV-A and HRV-B and that among hospitalized children with acute lower respiratory tract infection in China, the three HRV genotypes have similar clinical characteristics.

Authors+Show Affiliations

The People's Hospital of Hunan Province, Changsha, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24390928

Citation

Zeng, Sai-Zhen, et al. "Prevalence of Human Rhinovirus in Children Admitted to Hospital With Acute Lower Respiratory Tract Infections in Changsha, China." Journal of Medical Virology, vol. 86, no. 11, 2014, pp. 1983-9.
Zeng SZ, Xiao NG, Xie ZP, et al. Prevalence of human rhinovirus in children admitted to hospital with acute lower respiratory tract infections in Changsha, China. J Med Virol. 2014;86(11):1983-9.
Zeng, S. Z., Xiao, N. G., Xie, Z. P., Xie, G. C., Zhong, L. L., Wang, J., Huang, H., Zhang, B., & Duan, Z. J. (2014). Prevalence of human rhinovirus in children admitted to hospital with acute lower respiratory tract infections in Changsha, China. Journal of Medical Virology, 86(11), 1983-9. https://doi.org/10.1002/jmv.23861
Zeng SZ, et al. Prevalence of Human Rhinovirus in Children Admitted to Hospital With Acute Lower Respiratory Tract Infections in Changsha, China. J Med Virol. 2014;86(11):1983-9. PubMed PMID: 24390928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of human rhinovirus in children admitted to hospital with acute lower respiratory tract infections in Changsha, China. AU - Zeng,Sai-Zhen, AU - Xiao,Ni-Guang, AU - Xie,Zhi-Ping, AU - Xie,Guang-Cheng, AU - Zhong,Li-Li, AU - Wang,Juan, AU - Huang,Han, AU - Zhang,Bing, AU - Duan,Zhao-Jun, Y1 - 2014/01/06/ PY - 2013/11/08/accepted PY - 2014/1/7/entrez PY - 2014/1/7/pubmed PY - 2015/10/16/medline KW - China KW - acute lower respiratory tract infections KW - child KW - human rhinovirus SP - 1983 EP - 9 JF - Journal of medical virology JO - J Med Virol VL - 86 IS - 11 N2 - Human rhinovirus (HRV) is a causative agent of acute respiratory tract infections. This study analyzed the prevalence and clinical characteristics of three HRV groups (HRV-A, -B, and -C) among 1,165 children aged 14 years or younger who were hospitalized with acute lower respiratory tract infection in China. PCR or reverse transcription-PCR was performed to detect 14 respiratory viruses in nasopharyngeal aspirates collected from September 2007 to August 2008 in Changsha, China. HRV was detected in 202 (17.3%) of the 1,165 children; 25.3% of the HRV-positive children were 13-36 months of age (χ(2) = 22.803, P = 0.000). HRV was detected year round and peaked between September and December. Fifty-three percent of the HRV-positive samples were also positive for other respiratory viruses; respiratory syncytial virus (RSV) was the most common secondary virus. Phylogenetic analysis using the VP4/VP2 region grouped the HRV-positive strains as follows: 101 HRV-A (50.0%), 21 HRV-B (10.4%), and 80 HRV-C (39.6%). HRV-A infections occurred predominantly in spring and autumn, and the peak prevalence of HRV-C was in early winter and late autumn. HRV-B infections were less common in spring (χ(2) = 31.914, P = 0.000). No significant difference in clinical severity or presentation was found between patients with HRV single infection and HRV co-detections. Furthermore, the clinical characterizations did not differ among the three HRV species. These results suggest that HRV-C is an important viral agent along with HRV-A and HRV-B and that among hospitalized children with acute lower respiratory tract infection in China, the three HRV genotypes have similar clinical characteristics. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/24390928/Prevalence_of_human_rhinovirus_in_children_admitted_to_hospital_with_acute_lower_respiratory_tract_infections_in_Changsha_China_ DB - PRIME DP - Unbound Medicine ER -