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Duration of untreated psychosis is associated with temporal and occipitotemporal gray matter volume decrease in treatment naïve schizophrenia.
PLoS One 2013; 8(12):e83679Plos

Abstract

BACKGROUND

Long duration of untreated psychosis (DUP) is associated with poor treatment outcome. Whether or not DUP is related to brain gray matter volume abnormalities in antipsychotic medication treatment naïve schizophrenia remains unclear at this time.

METHODS

Patients with treatment-naïve schizophrenia and healthy controls went through brain scan using high resolution Magnetic Resonance Imaging. DUP was evaluated using the Nottingham Onset Schedule (NOS), and dichotomized as short DUP (≤ 26 weeks) or long DUP (>26 weeks). Voxel-based methods were used for volumetric measure in the brain.

RESULTS

Fifty-seven patients (27 short DUP and 30 long DUP) and 30 healthy controls were included in the analysis. There were significant gray matter volumetric differences among the 3 groups in bilateral parahippocampus gyri, right superior temporal gyrus, left fusiform gyrus, left middle temporal gyrus, and right superior frontal gyrus (p's<0.01). Compared with healthy controls, the long DUP group had significantly smaller volume in all these regions (p's <0.05). Compared with the short-DUP group, the long-DUP group had significantly smaller volume in right superior temporal gyrus, left fusiform gyrus, and left middle temporal gyrus (p's<0.01).

CONCLUSION

Our findings suggest that DUP is associated with temporal and occipitotemporal gray matter volume decrease in treatment naïve schizophrenia. The brain structural changes in untreated psychosis might contribute to poor treatment response and long-term prognosis in this patient population.

Authors+Show Affiliations

Institute of Mental Health, the Second Xiangya Hospital, Central South University, Changsha, China.Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.Department of Psychiatry, 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.UMass Memorial Medical Center, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.UMass Memorial Medical Center, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.Institute of Mental Health, the Second Xiangya Hospital, Central South University, Changsha, China.Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.Institute of Mental Health, the Second Xiangya Hospital, Central South University, Changsha, China.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24391807

Citation

Guo, Xiaofeng, et al. "Duration of Untreated Psychosis Is Associated With Temporal and Occipitotemporal Gray Matter Volume Decrease in Treatment Naïve Schizophrenia." PloS One, vol. 8, no. 12, 2013, pp. e83679.
Guo X, Li J, Wei Q, et al. Duration of untreated psychosis is associated with temporal and occipitotemporal gray matter volume decrease in treatment naïve schizophrenia. PLoS ONE. 2013;8(12):e83679.
Guo, X., Li, J., Wei, Q., Fan, X., Kennedy, D. N., Shen, Y., ... Zhao, J. (2013). Duration of untreated psychosis is associated with temporal and occipitotemporal gray matter volume decrease in treatment naïve schizophrenia. PloS One, 8(12), pp. e83679. doi:10.1371/journal.pone.0083679.
Guo X, et al. Duration of Untreated Psychosis Is Associated With Temporal and Occipitotemporal Gray Matter Volume Decrease in Treatment Naïve Schizophrenia. PLoS ONE. 2013;8(12):e83679. PubMed PMID: 24391807.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Duration of untreated psychosis is associated with temporal and occipitotemporal gray matter volume decrease in treatment naïve schizophrenia. AU - Guo,Xiaofeng, AU - Li,Jun, AU - Wei,Qinling, AU - Fan,Xiaoduo, AU - Kennedy,David N, AU - Shen,Yidong, AU - Chen,Huafu, AU - Zhao,Jingping, Y1 - 2013/12/31/ PY - 2013/06/12/received PY - 2013/11/15/accepted PY - 2014/1/7/entrez PY - 2014/1/7/pubmed PY - 2014/9/19/medline SP - e83679 EP - e83679 JF - PloS one JO - PLoS ONE VL - 8 IS - 12 N2 - BACKGROUND: Long duration of untreated psychosis (DUP) is associated with poor treatment outcome. Whether or not DUP is related to brain gray matter volume abnormalities in antipsychotic medication treatment naïve schizophrenia remains unclear at this time. METHODS: Patients with treatment-naïve schizophrenia and healthy controls went through brain scan using high resolution Magnetic Resonance Imaging. DUP was evaluated using the Nottingham Onset Schedule (NOS), and dichotomized as short DUP (≤ 26 weeks) or long DUP (>26 weeks). Voxel-based methods were used for volumetric measure in the brain. RESULTS: Fifty-seven patients (27 short DUP and 30 long DUP) and 30 healthy controls were included in the analysis. There were significant gray matter volumetric differences among the 3 groups in bilateral parahippocampus gyri, right superior temporal gyrus, left fusiform gyrus, left middle temporal gyrus, and right superior frontal gyrus (p's<0.01). Compared with healthy controls, the long DUP group had significantly smaller volume in all these regions (p's <0.05). Compared with the short-DUP group, the long-DUP group had significantly smaller volume in right superior temporal gyrus, left fusiform gyrus, and left middle temporal gyrus (p's<0.01). CONCLUSION: Our findings suggest that DUP is associated with temporal and occipitotemporal gray matter volume decrease in treatment naïve schizophrenia. The brain structural changes in untreated psychosis might contribute to poor treatment response and long-term prognosis in this patient population. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/24391807/Duration_of_untreated_psychosis_is_associated_with_temporal_and_occipitotemporal_gray_matter_volume_decrease_in_treatment_naïve_schizophrenia_ L2 - http://dx.plos.org/10.1371/journal.pone.0083679 DB - PRIME DP - Unbound Medicine ER -