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The dissolution enhancement of piroxicam in its physical mixtures and solid dispersion formulations using gluconolactone and glucosamine hydrochloride as potential carriers.
Pharm Dev Technol. 2015 Jan; 20(1):74-83.PD

Abstract

The solid dispersion technique is one of the most effective methods for improving the dissolution rate of poorly water-soluble drugs; however this is reliant on a suitable carrier and solvent being selected. The work presented explores amino sugars (d-glucosamine HCl and d-gluconolactone) as potential hydrophilic carriers to improve dissolution rate of a poorly water-soluble drug, piroxicam, from physical mixtures and solid dispersion formulations. Solid dispersions of the drug and carrier were prepared using different ratios by the conventional solvent evaporation method. Acetone was used as solvent in the preparation of solid dispersions. Physical mixtures of piroxicam and carrier were also prepared for comparison. The properties of all solid dispersions and physical mixtures were studied using a dissolution tester, Fourier transform infrared, XRD, SEM and differential scanning calorimetry. These results showed that the presence of glucosamine or gluconolactone can increase dissolution rate of piroxicam compared to pure piroxicam. Glucosamine or Gluconolactone could be used as carrier in solid dispersion formulations and physical mixtures to enhance the dissolution rate. Solid state studies showed that no significant changes occurred for piroxicam in physical mixtures and solid dispersion.

Authors+Show Affiliations

Medway School of Pharmacy, University of Kent , Kent , UK .No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24392858

Citation

Al-Hamidi, Hiba, et al. "The Dissolution Enhancement of Piroxicam in Its Physical Mixtures and Solid Dispersion Formulations Using Gluconolactone and Glucosamine Hydrochloride as Potential Carriers." Pharmaceutical Development and Technology, vol. 20, no. 1, 2015, pp. 74-83.
Al-Hamidi H, Obeidat WM, Nokhodchi A. The dissolution enhancement of piroxicam in its physical mixtures and solid dispersion formulations using gluconolactone and glucosamine hydrochloride as potential carriers. Pharm Dev Technol. 2015;20(1):74-83.
Al-Hamidi, H., Obeidat, W. M., & Nokhodchi, A. (2015). The dissolution enhancement of piroxicam in its physical mixtures and solid dispersion formulations using gluconolactone and glucosamine hydrochloride as potential carriers. Pharmaceutical Development and Technology, 20(1), 74-83. https://doi.org/10.3109/10837450.2013.871029
Al-Hamidi H, Obeidat WM, Nokhodchi A. The Dissolution Enhancement of Piroxicam in Its Physical Mixtures and Solid Dispersion Formulations Using Gluconolactone and Glucosamine Hydrochloride as Potential Carriers. Pharm Dev Technol. 2015;20(1):74-83. PubMed PMID: 24392858.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The dissolution enhancement of piroxicam in its physical mixtures and solid dispersion formulations using gluconolactone and glucosamine hydrochloride as potential carriers. AU - Al-Hamidi,Hiba, AU - Obeidat,Wasfy M, AU - Nokhodchi,Ali, Y1 - 2014/01/06/ PY - 2014/1/8/entrez PY - 2014/1/8/pubmed PY - 2015/12/31/medline KW - Dissolution rate KW - gluconolactone KW - glucosamine KW - piroxicam KW - polymorphism KW - solid dispersion SP - 74 EP - 83 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 20 IS - 1 N2 - The solid dispersion technique is one of the most effective methods for improving the dissolution rate of poorly water-soluble drugs; however this is reliant on a suitable carrier and solvent being selected. The work presented explores amino sugars (d-glucosamine HCl and d-gluconolactone) as potential hydrophilic carriers to improve dissolution rate of a poorly water-soluble drug, piroxicam, from physical mixtures and solid dispersion formulations. Solid dispersions of the drug and carrier were prepared using different ratios by the conventional solvent evaporation method. Acetone was used as solvent in the preparation of solid dispersions. Physical mixtures of piroxicam and carrier were also prepared for comparison. The properties of all solid dispersions and physical mixtures were studied using a dissolution tester, Fourier transform infrared, XRD, SEM and differential scanning calorimetry. These results showed that the presence of glucosamine or gluconolactone can increase dissolution rate of piroxicam compared to pure piroxicam. Glucosamine or Gluconolactone could be used as carrier in solid dispersion formulations and physical mixtures to enhance the dissolution rate. Solid state studies showed that no significant changes occurred for piroxicam in physical mixtures and solid dispersion. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/24392858/The_dissolution_enhancement_of_piroxicam_in_its_physical_mixtures_and_solid_dispersion_formulations_using_gluconolactone_and_glucosamine_hydrochloride_as_potential_carriers_ L2 - https://www.tandfonline.com/doi/full/10.3109/10837450.2013.871029 DB - PRIME DP - Unbound Medicine ER -