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Progression from impaired fasting glucose to type 2 diabetes mellitus among Chinese subjects with and without hypertension in a primary care setting.
J Diabetes 2014; 6(5):438-46JD

Abstract

BACKGROUND

The progression from impaired fasting glucose (IFG) to type 2 diabetes mellitus (T2DM) in Chinese subjects, with and without hypertension, in a primary care setting was unknown.

METHODS

The present retrospective multicenter 5-year (2002-2007) cohort study was performed on IFG subjects attending 23 general outpatient clinics who were identified by their elevated fasting blood glucose laboratory results. Development of T2DM was determined by physician diagnosis of T2DM or starting of oral antidiabetic drugs within 5 years. The relationship between the time of T2DM diagnosis and subject characteristics was assessed by adjusted hazard ratios (aHR) from Cox hazards model.

RESULTS

Of the 9161 IFG subjects, 4080 (45%) were men and 5081 (55%) were women. There were 1998 subjects who developed T2DM. The 5-year cumulative incidence was 0.218, whereas the overall annual incidence rate was 5.981/100 person-years. Subjects were more likely to develop T2DM if they were hypertensive (aHR = 1.44; 95% confidence interval [CI] 1.28-1.62; P < 0.001), aged <60 years (aHR = 1.36, 95% CI 1.24-1.49; P < 0.001), female (aHR = 1.18, 95% CI 1.08-1.29; P < 0.001), and had higher fasting glucose levels (6.39 ± 0.49 vs 6.24 ± 0.43 mmol/L in the group that developed T2DM vs the group without T2DM, respectively; aHR = 2.01, 95% CI 1.83-2.20; P < 0.001).

CONCLUSION

Overall, more than one-fifth of IFG subjects in the primary care setting developed T2DM within 5 years. Health care professionals can target interventions to patients with risk factors for disease progression.

Authors+Show Affiliations

Department of Family Medicine and Primary Health Care, Kowloon West Cluster, Hospital Authority, Kowloon.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

24393475

Citation

Fu, Sau Nga, et al. "Progression From Impaired Fasting Glucose to Type 2 Diabetes Mellitus Among Chinese Subjects With and Without Hypertension in a Primary Care Setting." Journal of Diabetes, vol. 6, no. 5, 2014, pp. 438-46.
Fu SN, Luk W, Wong CK, et al. Progression from impaired fasting glucose to type 2 diabetes mellitus among Chinese subjects with and without hypertension in a primary care setting. J Diabetes. 2014;6(5):438-46.
Fu, S. N., Luk, W., Wong, C. K., & Cheung, K. L. (2014). Progression from impaired fasting glucose to type 2 diabetes mellitus among Chinese subjects with and without hypertension in a primary care setting. Journal of Diabetes, 6(5), pp. 438-46. doi:10.1111/1753-0407.12120.
Fu SN, et al. Progression From Impaired Fasting Glucose to Type 2 Diabetes Mellitus Among Chinese Subjects With and Without Hypertension in a Primary Care Setting. J Diabetes. 2014;6(5):438-46. PubMed PMID: 24393475.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Progression from impaired fasting glucose to type 2 diabetes mellitus among Chinese subjects with and without hypertension in a primary care setting. AU - Fu,Sau Nga, AU - Luk,Wan, AU - Wong,Carlos King Ho, AU - Cheung,Kwok Leung, Y1 - 2014/02/18/ PY - 2013/09/17/received PY - 2013/12/10/revised PY - 2013/12/17/accepted PY - 2014/1/8/entrez PY - 2014/1/8/pubmed PY - 2015/5/12/medline KW - disease progression KW - hyperglycemia KW - hypertension KW - primary health care KW - type 2 diabetes mellitus KW - 关键词:疾病进展,高血糖,高血压,初级卫生保健,2型糖尿病 SP - 438 EP - 46 JF - Journal of diabetes JO - J Diabetes VL - 6 IS - 5 N2 - BACKGROUND: The progression from impaired fasting glucose (IFG) to type 2 diabetes mellitus (T2DM) in Chinese subjects, with and without hypertension, in a primary care setting was unknown. METHODS: The present retrospective multicenter 5-year (2002-2007) cohort study was performed on IFG subjects attending 23 general outpatient clinics who were identified by their elevated fasting blood glucose laboratory results. Development of T2DM was determined by physician diagnosis of T2DM or starting of oral antidiabetic drugs within 5 years. The relationship between the time of T2DM diagnosis and subject characteristics was assessed by adjusted hazard ratios (aHR) from Cox hazards model. RESULTS: Of the 9161 IFG subjects, 4080 (45%) were men and 5081 (55%) were women. There were 1998 subjects who developed T2DM. The 5-year cumulative incidence was 0.218, whereas the overall annual incidence rate was 5.981/100 person-years. Subjects were more likely to develop T2DM if they were hypertensive (aHR = 1.44; 95% confidence interval [CI] 1.28-1.62; P < 0.001), aged <60 years (aHR = 1.36, 95% CI 1.24-1.49; P < 0.001), female (aHR = 1.18, 95% CI 1.08-1.29; P < 0.001), and had higher fasting glucose levels (6.39 ± 0.49 vs 6.24 ± 0.43 mmol/L in the group that developed T2DM vs the group without T2DM, respectively; aHR = 2.01, 95% CI 1.83-2.20; P < 0.001). CONCLUSION: Overall, more than one-fifth of IFG subjects in the primary care setting developed T2DM within 5 years. Health care professionals can target interventions to patients with risk factors for disease progression. SN - 1753-0407 UR - https://www.unboundmedicine.com/medline/citation/24393475/Progression_from_impaired_fasting_glucose_to_type_2_diabetes_mellitus_among_Chinese_subjects_with_and_without_hypertension_in_a_primary_care_setting_ L2 - https://doi.org/10.1111/1753-0407.12120 DB - PRIME DP - Unbound Medicine ER -