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The placebo-nocebo response: controversies and challenges from clinical and research perspective.
Eur Neuropsychopharmacol 2014; 24(3):333-41EN

Abstract

Placebo and nocebo responses fascinate, confuse, mystify and challenge. They are genuine social, cultural and psychobiological phenomena which can significantly modify the overall treatment outcome. The placebo-nocebo phenomenon represents a very good model for our better understanding the role of treatment context and how the words, indices, symbols and icons act on our brains. Placebo response is associated with reward expectancy and relief of anticipatory anxiety, while nocebo response is related to lack of reward/positive expectancy and to increase of anticipatory anxiety. Placebo-nocebo responses are mediated through changes in various cortico-subcortical networks and psychophysiological systems. In spite of many existing complementary theories and still growing research on placebo and nocebo response, the implementation of our current knowledge to benefit basic research, clinical trials and routine clinical practice is still so scarce.

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    Authors+Show Affiliations

    Jakovljevic M
    Department of Psychiatry, University Hospital Center, Kispaticeva 12, 10000 Zagreb, Croatia. Electronic address: psychiatry@kbc-zagreb.hr.

    MeSH

    BrainClinical Trials as TopicEvidence-Based MedicineHumansInformed ConsentNocebo EffectPatient Acceptance of Health CarePlacebo Effect

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    24393653

    Citation

    Jakovljevic, Miro. "The Placebo-nocebo Response: Controversies and Challenges From Clinical and Research Perspective." European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, vol. 24, no. 3, 2014, pp. 333-41.
    Jakovljevic M. The placebo-nocebo response: controversies and challenges from clinical and research perspective. Eur Neuropsychopharmacol. 2014;24(3):333-41.
    Jakovljevic, M. (2014). The placebo-nocebo response: controversies and challenges from clinical and research perspective. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 24(3), pp. 333-41. doi:10.1016/j.euroneuro.2013.11.014.
    Jakovljevic M. The Placebo-nocebo Response: Controversies and Challenges From Clinical and Research Perspective. Eur Neuropsychopharmacol. 2014;24(3):333-41. PubMed PMID: 24393653.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The placebo-nocebo response: controversies and challenges from clinical and research perspective. A1 - Jakovljevic,Miro, Y1 - 2013/12/08/ PY - 2013/09/20/received PY - 2013/11/25/revised PY - 2013/11/28/accepted PY - 2014/1/8/entrez PY - 2014/1/8/pubmed PY - 2014/12/15/medline KW - Creative psychopharmacotherapy KW - Nocebo KW - Placebo KW - Specific and non-specific treatment effects KW - Treatment context SP - 333 EP - 41 JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JO - Eur Neuropsychopharmacol VL - 24 IS - 3 N2 - Placebo and nocebo responses fascinate, confuse, mystify and challenge. They are genuine social, cultural and psychobiological phenomena which can significantly modify the overall treatment outcome. The placebo-nocebo phenomenon represents a very good model for our better understanding the role of treatment context and how the words, indices, symbols and icons act on our brains. Placebo response is associated with reward expectancy and relief of anticipatory anxiety, while nocebo response is related to lack of reward/positive expectancy and to increase of anticipatory anxiety. Placebo-nocebo responses are mediated through changes in various cortico-subcortical networks and psychophysiological systems. In spite of many existing complementary theories and still growing research on placebo and nocebo response, the implementation of our current knowledge to benefit basic research, clinical trials and routine clinical practice is still so scarce. SN - 1873-7862 UR - https://www.unboundmedicine.com/medline/citation/24393653/The_placebo_nocebo_response:_controversies_and_challenges_from_clinical_and_research_perspective_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0924-977X(13)00345-3 DB - PRIME DP - Unbound Medicine ER -