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The role of vitamin D levels and vitamin D receptor polymorphism on Parkinson's disease in the Faroe Islands.
Neurosci Lett. 2014 Feb 21; 561:74-9.NL

Abstract

The role of vitamin D in Parkinson's disease (PD) has been proposed and both low serum 25-hydroxyvitamin D levels (25(OH)D) and vitamin D receptor polymorphisms (VDR) have been linked to PD. The aim of this study is to investigate the associations among 25(OH)D and three VDR polymorphisms and PD in the Faroese population where the prevalence of PD is high. We conducted a case-control study where 121 cases were studied for 25(OH)D levels and VDR polymorphisms against 235 randomly selected controls, matched by gender and age. No significant difference was observed in 25(OH)D levels between PD cases and controls (P=0.49), although cases had slightly lower values than controls. As well, no differences were found in genotype frequencies between cases and controls in the VDR polymorphisms studied (ApaI, BsmI, TaqI) (P=0.70, P=0.56 and P=0.54, respectively). However, we found that VDR ApaI/AC genotype was significantly associated with 25(OH)D levels (P=0.01). Although our results indicate no association between PD and vitamin D polymorphisms and/or 25(OH)D levels, the study cannot exclude a weak association. However, the known doubling in PD prevalence in the Faroe Islands cannot be explained by the polymorphisms examined in the VDR gene or the 25(OH)D levels and has to be explored further.

Authors+Show Affiliations

Department of Occupational Medicine and Public Health, The Faroese Hospital System, Tórshavn, Faroe Islands. Electronic address: maria@health.fo.Department of Occupational Medicine and Public Health, The Faroese Hospital System, Tórshavn, Faroe Islands.Food and Veterinary Authority, National Reference Laboratory for Fish Diseases, Tórshavn, Faroe Islands.Department of Clinical Biochemistry, Lillebaelts Hospital, Vejle, Denmark.Department of Occupational Medicine and Public Health, The Faroese Hospital System, Tórshavn, Faroe Islands.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24394913

Citation

Petersen, Maria Skaalum, et al. "The Role of Vitamin D Levels and Vitamin D Receptor Polymorphism On Parkinson's Disease in the Faroe Islands." Neuroscience Letters, vol. 561, 2014, pp. 74-9.
Petersen MS, Bech S, Christiansen DH, et al. The role of vitamin D levels and vitamin D receptor polymorphism on Parkinson's disease in the Faroe Islands. Neurosci Lett. 2014;561:74-9.
Petersen, M. S., Bech, S., Christiansen, D. H., Schmedes, A. V., & Halling, J. (2014). The role of vitamin D levels and vitamin D receptor polymorphism on Parkinson's disease in the Faroe Islands. Neuroscience Letters, 561, 74-9. https://doi.org/10.1016/j.neulet.2013.12.053
Petersen MS, et al. The Role of Vitamin D Levels and Vitamin D Receptor Polymorphism On Parkinson's Disease in the Faroe Islands. Neurosci Lett. 2014 Feb 21;561:74-9. PubMed PMID: 24394913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of vitamin D levels and vitamin D receptor polymorphism on Parkinson's disease in the Faroe Islands. AU - Petersen,Maria Skaalum, AU - Bech,Sára, AU - Christiansen,Debes Hammershaimb, AU - Schmedes,Anna Vibeke, AU - Halling,Jónrit, Y1 - 2014/01/03/ PY - 2013/08/15/received PY - 2013/12/05/revised PY - 2013/12/21/accepted PY - 2014/1/8/entrez PY - 2014/1/8/pubmed PY - 2014/10/8/medline KW - Faroe Islands KW - Parkinson's disease KW - Polymorphism KW - Vitamin D receptor SP - 74 EP - 9 JF - Neuroscience letters JO - Neurosci Lett VL - 561 N2 - The role of vitamin D in Parkinson's disease (PD) has been proposed and both low serum 25-hydroxyvitamin D levels (25(OH)D) and vitamin D receptor polymorphisms (VDR) have been linked to PD. The aim of this study is to investigate the associations among 25(OH)D and three VDR polymorphisms and PD in the Faroese population where the prevalence of PD is high. We conducted a case-control study where 121 cases were studied for 25(OH)D levels and VDR polymorphisms against 235 randomly selected controls, matched by gender and age. No significant difference was observed in 25(OH)D levels between PD cases and controls (P=0.49), although cases had slightly lower values than controls. As well, no differences were found in genotype frequencies between cases and controls in the VDR polymorphisms studied (ApaI, BsmI, TaqI) (P=0.70, P=0.56 and P=0.54, respectively). However, we found that VDR ApaI/AC genotype was significantly associated with 25(OH)D levels (P=0.01). Although our results indicate no association between PD and vitamin D polymorphisms and/or 25(OH)D levels, the study cannot exclude a weak association. However, the known doubling in PD prevalence in the Faroe Islands cannot be explained by the polymorphisms examined in the VDR gene or the 25(OH)D levels and has to be explored further. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/24394913/The_role_of_vitamin_D_levels_and_vitamin_D_receptor_polymorphism_on_Parkinson's_disease_in_the_Faroe_Islands_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(13)01134-8 DB - PRIME DP - Unbound Medicine ER -