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Immunogenicity of a 2009 pandemic influenza virus A H1N1 vaccine, administered simultaneously with the seasonal influenza vaccine, in children receiving chemotherapy.
Pediatr Blood Cancer 2014; 61(6):1013-6PB

Abstract

BACKGROUND

No examination of simultaneous vaccination against pandemic H1N1 and the seasonal influenza virus strains, in children with cancer receiving chemotherapy, are yet published. We investigated the immunogenicity of a whole-virion, inactivated, adjuvanted pandemic H1N1, and seasonal influenza vaccines administered simultaneously to children with cancer undergoing chemotherapy.

PROCEDURE

We prospectively enrolled 27 pediatric patients receiving therapy for various types of cancer. All received influenza vaccination once in a seasonal risk period. We checked hemaglutination-inhibition (HAI) antibody titers in the sera of patients before, and 21-28 days after vaccination. Seroprotective titer was defined as an antibody titer ≥ 40, and seroresponse as ≥ 4-fold increase in antibody titers after vaccination.

RESULTS

The pre- and post-vaccination seroprotective rates were H1N1: 33-48%, H3N2: 56-78%, B: 0-15% for seasonal influenza, and for pandemic H1N1: 15-37%. The seroresponse rates for seasonal influenza H1N1, H3N2, and B were 22%, 37%, and 22%, respectively, and 30% for the pandemic H1N1 vaccine.

CONCLUSIONS

Whole-virion, inactivated, adjuvanted vaccine for the pandemic H1N1 Influenza A virus and the seasonal influenza vaccines were found safe and partially immunogenic in children with cancer receiving chemotherapy. The only determinants of responsiveness were lymphocyte count and serum immunoglobulin-G. Only influenza B vaccine elicited significant differences in differences in pre- and post-vaccination seroprotective rates. The response to vaccination for pandemic H1N1 is as effective as other vaccines, however administration of a single vaccine during chemotherapy is more comfortable for pediatric cancer patients.

Authors+Show Affiliations

Division of Pediatric Hematology and Oncology, Department of Pediatrics, Faculty of Medicine, University of Pécs, Pécs, Hungary.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study

Language

eng

PubMed ID

24395342

Citation

Ottóffy, Gábor, et al. "Immunogenicity of a 2009 Pandemic Influenza Virus a H1N1 Vaccine, Administered Simultaneously With the Seasonal Influenza Vaccine, in Children Receiving Chemotherapy." Pediatric Blood & Cancer, vol. 61, no. 6, 2014, pp. 1013-6.
Ottóffy G, Horváth P, Muth L, et al. Immunogenicity of a 2009 pandemic influenza virus A H1N1 vaccine, administered simultaneously with the seasonal influenza vaccine, in children receiving chemotherapy. Pediatr Blood Cancer. 2014;61(6):1013-6.
Ottóffy, G., Horváth, P., Muth, L., Sólyom, A., Garami, M., Kovács, G., ... Jankovics, I. (2014). Immunogenicity of a 2009 pandemic influenza virus A H1N1 vaccine, administered simultaneously with the seasonal influenza vaccine, in children receiving chemotherapy. Pediatric Blood & Cancer, 61(6), pp. 1013-6. doi:10.1002/pbc.24893.
Ottóffy G, et al. Immunogenicity of a 2009 Pandemic Influenza Virus a H1N1 Vaccine, Administered Simultaneously With the Seasonal Influenza Vaccine, in Children Receiving Chemotherapy. Pediatr Blood Cancer. 2014;61(6):1013-6. PubMed PMID: 24395342.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunogenicity of a 2009 pandemic influenza virus A H1N1 vaccine, administered simultaneously with the seasonal influenza vaccine, in children receiving chemotherapy. AU - Ottóffy,Gábor, AU - Horváth,Petra, AU - Muth,Lajos, AU - Sólyom,Alexander, AU - Garami,Miklós, AU - Kovács,Gábor, AU - Nyári,Tibor, AU - Molnár,Dénes, AU - Pauler,Gábor, AU - Jankovics,István, Y1 - 2014/01/03/ PY - 2013/07/19/received PY - 2013/11/12/accepted PY - 2014/1/8/entrez PY - 2014/1/8/pubmed PY - 2014/6/5/medline KW - chemotherapy KW - influenza KW - pandemic H1N1 KW - pediatric oncology KW - vaccine SP - 1013 EP - 6 JF - Pediatric blood & cancer JO - Pediatr Blood Cancer VL - 61 IS - 6 N2 - BACKGROUND: No examination of simultaneous vaccination against pandemic H1N1 and the seasonal influenza virus strains, in children with cancer receiving chemotherapy, are yet published. We investigated the immunogenicity of a whole-virion, inactivated, adjuvanted pandemic H1N1, and seasonal influenza vaccines administered simultaneously to children with cancer undergoing chemotherapy. PROCEDURE: We prospectively enrolled 27 pediatric patients receiving therapy for various types of cancer. All received influenza vaccination once in a seasonal risk period. We checked hemaglutination-inhibition (HAI) antibody titers in the sera of patients before, and 21-28 days after vaccination. Seroprotective titer was defined as an antibody titer ≥ 40, and seroresponse as ≥ 4-fold increase in antibody titers after vaccination. RESULTS: The pre- and post-vaccination seroprotective rates were H1N1: 33-48%, H3N2: 56-78%, B: 0-15% for seasonal influenza, and for pandemic H1N1: 15-37%. The seroresponse rates for seasonal influenza H1N1, H3N2, and B were 22%, 37%, and 22%, respectively, and 30% for the pandemic H1N1 vaccine. CONCLUSIONS: Whole-virion, inactivated, adjuvanted vaccine for the pandemic H1N1 Influenza A virus and the seasonal influenza vaccines were found safe and partially immunogenic in children with cancer receiving chemotherapy. The only determinants of responsiveness were lymphocyte count and serum immunoglobulin-G. Only influenza B vaccine elicited significant differences in differences in pre- and post-vaccination seroprotective rates. The response to vaccination for pandemic H1N1 is as effective as other vaccines, however administration of a single vaccine during chemotherapy is more comfortable for pediatric cancer patients. SN - 1545-5017 UR - https://www.unboundmedicine.com/medline/citation/24395342/Immunogenicity_of_a_2009_pandemic_influenza_virus_A_H1N1_vaccine_administered_simultaneously_with_the_seasonal_influenza_vaccine_in_children_receiving_chemotherapy_ L2 - https://doi.org/10.1002/pbc.24893 DB - PRIME DP - Unbound Medicine ER -