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Meat consumption is associated with esophageal cancer risk in a meat- and cancer-histological-type dependent manner.
Dig Dis Sci 2014; 59(3):664-73DD

Abstract

BACKGROUND

We conducted a systematic review and meta-analysis of meat intake and esophageal cancer risk, with subgroup analyses based on meat type and histological type of cancer.

AIMS

The purpose of this study was to investigate the association between meat intake and risk of esophageal cancer.

METHODS

We searched MEDLINE, EMBASE and Cochrane Library (April 2013) for cohort and case-control studies that assessed meat intake and esophageal cancer risk. Random-effect or fixed-effect models were used to pool relative risks (RRs) from individual studies with heterogeneity and publication bias analyses carried out. Seven cohort and 28 case-control studies were included.

RESULTS

The summary RRs for esophageal cancer for the highest versus lowest consumption categories were 1.19 (95 % confidence interval [CI] 0.98-1.46) for total meat, 1.55 (95 % CI 1.22-1.96) for red meat, 1.33 (95 % CI 1.04-1.69) for processed meat, 0.72 (95 % CI 0.60-0.86) for white meat, 0.83 (95 % CI 0.72-0.96) for poultry, and 0.95 (95 % CI 0.76-1.19) for fish. When striated by histological subtype, positive associations were seen among esophageal squamous cell carcinoma and red meat, white meat and poultry, and esophageal adenocarcinoma with total meat and processed meat.

CONCLUSIONS

Meat consumption is associated with esophageal cancer risk, which depends on meat type and histological type of esophageal cancer. High intake of red meat and low intake of poultry are associated with an increased risk of esophageal squamous cell carcinoma. High meat intake, especially processed meat, is likely to increase esophageal adenocarcinoma risk. And fish consumption may not be associated with incidence of esophageal cancer.

Authors+Show Affiliations

Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Guangzhou Road 300, Nanjing, 210029, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

24395380

Citation

Zhu, Hong-Cheng, et al. "Meat Consumption Is Associated With Esophageal Cancer Risk in a Meat- and Cancer-histological-type Dependent Manner." Digestive Diseases and Sciences, vol. 59, no. 3, 2014, pp. 664-73.
Zhu HC, Yang X, Xu LP, et al. Meat consumption is associated with esophageal cancer risk in a meat- and cancer-histological-type dependent manner. Dig Dis Sci. 2014;59(3):664-73.
Zhu, H. C., Yang, X., Xu, L. P., Zhao, L. J., Tao, G. Z., Zhang, C., ... Sun, X. C. (2014). Meat consumption is associated with esophageal cancer risk in a meat- and cancer-histological-type dependent manner. Digestive Diseases and Sciences, 59(3), pp. 664-73. doi:10.1007/s10620-013-2928-y.
Zhu HC, et al. Meat Consumption Is Associated With Esophageal Cancer Risk in a Meat- and Cancer-histological-type Dependent Manner. Dig Dis Sci. 2014;59(3):664-73. PubMed PMID: 24395380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meat consumption is associated with esophageal cancer risk in a meat- and cancer-histological-type dependent manner. AU - Zhu,Hong-Cheng, AU - Yang,Xi, AU - Xu,Li-Ping, AU - Zhao,Lian-Jun, AU - Tao,Guang-Zhou, AU - Zhang,Chi, AU - Qin,Qin, AU - Cai,Jing, AU - Ma,Jian-Xin, AU - Mao,Wei-Dong, AU - Zhang,Xi-Zhi, AU - Cheng,Hong-Yan, AU - Sun,Xin-Chen, Y1 - 2014/01/07/ PY - 2013/07/06/received PY - 2013/10/16/accepted PY - 2014/1/8/entrez PY - 2014/1/8/pubmed PY - 2014/4/17/medline SP - 664 EP - 73 JF - Digestive diseases and sciences JO - Dig. Dis. Sci. VL - 59 IS - 3 N2 - BACKGROUND: We conducted a systematic review and meta-analysis of meat intake and esophageal cancer risk, with subgroup analyses based on meat type and histological type of cancer. AIMS: The purpose of this study was to investigate the association between meat intake and risk of esophageal cancer. METHODS: We searched MEDLINE, EMBASE and Cochrane Library (April 2013) for cohort and case-control studies that assessed meat intake and esophageal cancer risk. Random-effect or fixed-effect models were used to pool relative risks (RRs) from individual studies with heterogeneity and publication bias analyses carried out. Seven cohort and 28 case-control studies were included. RESULTS: The summary RRs for esophageal cancer for the highest versus lowest consumption categories were 1.19 (95 % confidence interval [CI] 0.98-1.46) for total meat, 1.55 (95 % CI 1.22-1.96) for red meat, 1.33 (95 % CI 1.04-1.69) for processed meat, 0.72 (95 % CI 0.60-0.86) for white meat, 0.83 (95 % CI 0.72-0.96) for poultry, and 0.95 (95 % CI 0.76-1.19) for fish. When striated by histological subtype, positive associations were seen among esophageal squamous cell carcinoma and red meat, white meat and poultry, and esophageal adenocarcinoma with total meat and processed meat. CONCLUSIONS: Meat consumption is associated with esophageal cancer risk, which depends on meat type and histological type of esophageal cancer. High intake of red meat and low intake of poultry are associated with an increased risk of esophageal squamous cell carcinoma. High meat intake, especially processed meat, is likely to increase esophageal adenocarcinoma risk. And fish consumption may not be associated with incidence of esophageal cancer. SN - 1573-2568 UR - https://www.unboundmedicine.com/medline/citation/24395380/Meat_consumption_is_associated_with_esophageal_cancer_risk_in_a_meat__and_cancer_histological_type_dependent_manner_ L2 - https://doi.org/10.1007/s10620-013-2928-y DB - PRIME DP - Unbound Medicine ER -