TY - JOUR T1 - Inherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema. AU - Peng,Ying-Jie, AU - Makarenko,Vladislav V, AU - Nanduri,Jayasri, AU - Vasavda,Chirag, AU - Raghuraman,Gayatri, AU - Yuan,Guoxiang, AU - Gadalla,Moataz M, AU - Kumar,Ganesh K, AU - Snyder,Solomon H, AU - Prabhakar,Nanduri R, Y1 - 2014/01/06/ PY - 2014/1/8/entrez PY - 2014/1/8/pubmed PY - 2014/3/29/medline KW - cystathionine-γ-lyase KW - gasotransmitters KW - high-altitude hypoxia KW - sympathetic tone SP - 1174 EP - 9 JF - Proceedings of the National Academy of Sciences of the United States of America JO - Proc Natl Acad Sci U S A VL - 111 IS - 3 N2 - Oxygen (O2) sensing by the carotid body and its chemosensory reflex is critical for homeostatic regulation of breathing and blood pressure. Humans and animals exhibit substantial interindividual variation in this chemosensory reflex response, with profound effects on cardiorespiratory functions. However, the underlying mechanisms are not known. Here, we report that inherent variations in carotid body O2 sensing by carbon monoxide (CO)-sensitive hydrogen sulfide (H2S) signaling contribute to reflex variation in three genetically distinct rat strains. Compared with Sprague-Dawley (SD) rats, Brown-Norway (BN) rats exhibit impaired carotid body O2 sensing and develop pulmonary edema as a consequence of poor ventilatory adaptation to hypobaric hypoxia. Spontaneous Hypertensive (SH) rat carotid bodies display inherent hypersensitivity to hypoxia and develop hypertension. BN rat carotid bodies have naturally higher CO and lower H2S levels than SD rat, whereas SH carotid bodies have reduced CO and greater H2S generation. Higher CO levels in BN rats were associated with higher substrate affinity of the enzyme heme oxygenase 2, whereas SH rats present lower substrate affinity and, thus, reduced CO generation. Reducing CO levels in BN rat carotid bodies increased H2S generation, restoring O2 sensing and preventing hypoxia-induced pulmonary edema. Increasing CO levels in SH carotid bodies reduced H2S generation, preventing hypersensitivity to hypoxia and controlling hypertension in SH rats. SN - 1091-6490 UR - https://www.unboundmedicine.com/medline/citation/24395806/Inherent_variations_in_CO_H2S_mediated_carotid_body_O2_sensing_mediate_hypertension_and_pulmonary_edema_ DB - PRIME DP - Unbound Medicine ER -