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Hepatitis E virus infection.
Clin Microbiol Rev. 2014 Jan; 27(1):116-38.CM

Abstract

Hepatitis E virus (HEV) infection is a worldwide disease. An improved understanding of the natural history of HEV infection has been achieved within the last decade. Several reservoirs and transmission modes have been identified. Hepatitis E is an underdiagnosed disease, in part due to the use of serological assays with low sensitivity. However, diagnostic tools, including nucleic acid-based tests, have been improved. The epidemiology and clinical features of hepatitis E differ between developing and developed countries. HEV infection is usually an acute self-limiting disease, but in developed countries it causes chronic infection with rapidly progressive cirrhosis in organ transplant recipients, patients with hematological malignancy requiring chemotherapy, and individuals with HIV. HEV also causes extrahepatic manifestations, including a number of neurological syndromes and renal injury. Acute infection usually requires no treatment, but chronic infection should be treated by reducing immunosuppression in transplant patients and/or the use of antiviral therapy. In this comprehensive review, we summarize the current knowledge about the virus itself, as well as the epidemiology, diagnostics, natural history, and management of HEV infection in developing and developed countries.

Links

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Authors+Show Affiliations

Kamar N
Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France.
Dalton HR
No affiliation info available
Abravanel F
No affiliation info available
Izopet J
No affiliation info available

MeSH

Chronic DiseaseDeveloped CountriesDeveloping CountriesDisease ReservoirsHepatitis EHepatitis E virusHumans

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24396139

Citation

Kamar, Nassim, et al. "Hepatitis E Virus Infection." Clinical Microbiology Reviews, vol. 27, no. 1, 2014, pp. 116-38.
Kamar N, Dalton HR, Abravanel F, et al. Hepatitis E virus infection. Clin Microbiol Rev. 2014;27(1):116-38.
Kamar, N., Dalton, H. R., Abravanel, F., & Izopet, J. (2014). Hepatitis E virus infection. Clinical Microbiology Reviews, 27(1), 116-38. https://doi.org/10.1128/CMR.00057-13
Kamar N, et al. Hepatitis E Virus Infection. Clin Microbiol Rev. 2014;27(1):116-38. PubMed PMID: 24396139.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis E virus infection. AU - Kamar,Nassim, AU - Dalton,Harry R, AU - Abravanel,Florence, AU - Izopet,Jacques, PY - 2014/1/8/entrez PY - 2014/1/8/pubmed PY - 2014/6/7/medline SP - 116 EP - 38 JF - Clinical microbiology reviews JO - Clin Microbiol Rev VL - 27 IS - 1 N2 - Hepatitis E virus (HEV) infection is a worldwide disease. An improved understanding of the natural history of HEV infection has been achieved within the last decade. Several reservoirs and transmission modes have been identified. Hepatitis E is an underdiagnosed disease, in part due to the use of serological assays with low sensitivity. However, diagnostic tools, including nucleic acid-based tests, have been improved. The epidemiology and clinical features of hepatitis E differ between developing and developed countries. HEV infection is usually an acute self-limiting disease, but in developed countries it causes chronic infection with rapidly progressive cirrhosis in organ transplant recipients, patients with hematological malignancy requiring chemotherapy, and individuals with HIV. HEV also causes extrahepatic manifestations, including a number of neurological syndromes and renal injury. Acute infection usually requires no treatment, but chronic infection should be treated by reducing immunosuppression in transplant patients and/or the use of antiviral therapy. In this comprehensive review, we summarize the current knowledge about the virus itself, as well as the epidemiology, diagnostics, natural history, and management of HEV infection in developing and developed countries. SN - 1098-6618 UR - https://www.unboundmedicine.com/medline/citation/24396139/full_citation DB - PRIME DP - Unbound Medicine ER -