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Distal humerus as delayed site of metastasis from small cell carcinoma of gallbladder.
Case Rep Gastrointest Med. 2013; 2013:946835.CR

Abstract

Background.

Small cell carcinoma (SCC) of the gallbladder is a rare entity and is often seen in elderly women. SCC of gallbladder is typically a nonsecretory carcinoid tumor without overt clinical symptoms and is often discovered at advanced stages. SCC of gallbladder carries a dismal prognosis as compared to SCC of lung and adenocarcinoma of gallbladder. To date, only 73 case reports have been published in the world literature. Case Presentation. Herein, we report a case of a 73-year-old Saudi woman who presented with one week history of right upper quadrant abdominal pain and obstructive jaundice and was found to be a case of locally advanced, metastatic SCC of gallbladder cT4N1M1 (liver, para-aortic lymph nodes, and bone). The patient was treated with neoadjuvant etoposide and cisplatin (EP) chemotherapy three cycles after biliary stenting followed by radical cholecystectomy, lymphadenectomy, and adjuvant EP chemotherapy and then one year later developed distal humerus osseous metastasis.

Conclusion.

SCC of the gallbladder is very rare entity and is often seen at advanced stages. Osseous metastases of peripheral skeleton from SCC gallbladder are rarely reported. Surgery is curative option but only for early stage tumors. Incorporation of chemotherapy along with radical resection increases the survival.

Authors+Show Affiliations

Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh 59046, Saudi Arabia.Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh 59046, Saudi Arabia.Medical Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh 59046, Saudi Arabia.Radiation Oncology, King Saud University, Riyadh 59046, Saudi Arabia.Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh 59046, Saudi Arabia.Department of Cytogenetics, Pathology, King Fahad Medical City, Riyadh 11525, Saudi Arabia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24396615

Citation

Tunio, Mutahir A., et al. "Distal Humerus as Delayed Site of Metastasis From Small Cell Carcinoma of Gallbladder." Case Reports in Gastrointestinal Medicine, vol. 2013, 2013, p. 946835.
Tunio MA, Alasiri M, Ali AM, et al. Distal humerus as delayed site of metastasis from small cell carcinoma of gallbladder. Case Rep Gastrointest Med. 2013;2013:946835.
Tunio, M. A., Alasiri, M., Ali, A. M., Alsaeed, E. F., Shuja, M., & Fatani, H. (2013). Distal humerus as delayed site of metastasis from small cell carcinoma of gallbladder. Case Reports in Gastrointestinal Medicine, 2013, 946835. https://doi.org/10.1155/2013/946835
Tunio MA, et al. Distal Humerus as Delayed Site of Metastasis From Small Cell Carcinoma of Gallbladder. Case Rep Gastrointest Med. 2013;2013:946835. PubMed PMID: 24396615.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distal humerus as delayed site of metastasis from small cell carcinoma of gallbladder. AU - Tunio,Mutahir A, AU - Alasiri,Mushabbab, AU - Ali,Asma Mohammed F, AU - Alsaeed,Eyad Fawzi, AU - Shuja,Muhammad, AU - Fatani,Hanadi, Y1 - 2013/12/14/ PY - 2013/10/17/received PY - 2013/11/19/accepted PY - 2014/1/8/entrez PY - 2014/1/8/pubmed PY - 2014/1/8/medline SP - 946835 EP - 946835 JF - Case reports in gastrointestinal medicine JO - Case Rep Gastrointest Med VL - 2013 N2 - Background. Small cell carcinoma (SCC) of the gallbladder is a rare entity and is often seen in elderly women. SCC of gallbladder is typically a nonsecretory carcinoid tumor without overt clinical symptoms and is often discovered at advanced stages. SCC of gallbladder carries a dismal prognosis as compared to SCC of lung and adenocarcinoma of gallbladder. To date, only 73 case reports have been published in the world literature. Case Presentation. Herein, we report a case of a 73-year-old Saudi woman who presented with one week history of right upper quadrant abdominal pain and obstructive jaundice and was found to be a case of locally advanced, metastatic SCC of gallbladder cT4N1M1 (liver, para-aortic lymph nodes, and bone). The patient was treated with neoadjuvant etoposide and cisplatin (EP) chemotherapy three cycles after biliary stenting followed by radical cholecystectomy, lymphadenectomy, and adjuvant EP chemotherapy and then one year later developed distal humerus osseous metastasis. Conclusion. SCC of the gallbladder is very rare entity and is often seen at advanced stages. Osseous metastases of peripheral skeleton from SCC gallbladder are rarely reported. Surgery is curative option but only for early stage tumors. Incorporation of chemotherapy along with radical resection increases the survival. SN - 2090-6528 UR - https://www.unboundmedicine.com/medline/citation/24396615/Distal_humerus_as_delayed_site_of_metastasis_from_small_cell_carcinoma_of_gallbladder_ L2 - https://dx.doi.org/10.1155/2013/946835 DB - PRIME DP - Unbound Medicine ER -
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