Tags

Type your tag names separated by a space and hit enter

Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents.
Inorg Chem. 2014 Jan 21; 53(2):727-36.IC

Abstract

Novel rhodium, iridium, and ruthenium half-sandwich complexes containing (N,N)-bound picolinamide ligands have been prepared for use as anticancer agents. The complexes show promising cytotoxicities, with the presence, position, and number of halides having a significant effect on the corresponding IC50 values. One ruthenium complex was found to be more cytotoxic than cisplatin on HT-29 and MCF-7 cells after 5 days and 1 h, respectively, and it remains active with MCF-7 cells even under hypoxic conditions, making it a promising candidate for in vivo studies.

Authors+Show Affiliations

School of Chemistry, University of Leeds , Leeds, LS2 9JT, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24397747

Citation

Almodares, Zahra, et al. "Rhodium, Iridium, and Ruthenium Half-sandwich Picolinamide Complexes as Anticancer Agents." Inorganic Chemistry, vol. 53, no. 2, 2014, pp. 727-36.
Almodares Z, Lucas SJ, Crossley BD, et al. Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents. Inorg Chem. 2014;53(2):727-36.
Almodares, Z., Lucas, S. J., Crossley, B. D., Basri, A. M., Pask, C. M., Hebden, A. J., Phillips, R. M., & McGowan, P. C. (2014). Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents. Inorganic Chemistry, 53(2), 727-36. https://doi.org/10.1021/ic401529u
Almodares Z, et al. Rhodium, Iridium, and Ruthenium Half-sandwich Picolinamide Complexes as Anticancer Agents. Inorg Chem. 2014 Jan 21;53(2):727-36. PubMed PMID: 24397747.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents. AU - Almodares,Zahra, AU - Lucas,Stephanie J, AU - Crossley,Benjamin D, AU - Basri,Aida M, AU - Pask,Christopher M, AU - Hebden,Andrew J, AU - Phillips,Roger M, AU - McGowan,Patrick C, Y1 - 2014/01/07/ PY - 2014/1/9/entrez PY - 2014/1/9/pubmed PY - 2014/9/27/medline SP - 727 EP - 36 JF - Inorganic chemistry JO - Inorg Chem VL - 53 IS - 2 N2 - Novel rhodium, iridium, and ruthenium half-sandwich complexes containing (N,N)-bound picolinamide ligands have been prepared for use as anticancer agents. The complexes show promising cytotoxicities, with the presence, position, and number of halides having a significant effect on the corresponding IC50 values. One ruthenium complex was found to be more cytotoxic than cisplatin on HT-29 and MCF-7 cells after 5 days and 1 h, respectively, and it remains active with MCF-7 cells even under hypoxic conditions, making it a promising candidate for in vivo studies. SN - 1520-510X UR - https://www.unboundmedicine.com/medline/citation/24397747/Rhodium_iridium_and_ruthenium_half_sandwich_picolinamide_complexes_as_anticancer_agents_ L2 - https://dx.doi.org/10.1021/ic401529u DB - PRIME DP - Unbound Medicine ER -