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Comparison of the effects of crocin, safranal and diclofenac on local inflammation and inflammatory pain responses induced by carrageenan in rats.
Pharmacol Rep. 2013; 65(5):1272-80.PR

Abstract

BACKGROUND

Crocin and safranal are the active substances of saffron and have many biological properties. In the present study, we compared the effects of crocin, safranal and diclofenac on local inflammation and its induced pain in rats.

METHODS

Local inflammation was induced by intraplantar (ipl) injection of carrageenan (100 μl, 2%). Paw thickness was measured before and after carrageenan injection. Inflammatory pain responses including cold allodynia, mechanical allodynia and hyperalgesia were assessed using acetone spray and von Frey filament tests, respectively. The number of neutrophils in inflammatory zone was counted 6.5 h after injection of carrageenan.

RESULTS

Carrageenan produced edema, cold allodynia, mechanical allodynia and hyperalgesia and caused neutrophil infiltration in paw tissues. Crocin at doses of 25, 50 and 100 mg/kg, safranal at doses of 0.5, 1 and 2 mg/kg and diclofenac (as a reference drug) at a dose of 10 mg/kg attenuated edema, suppressed inflammatory pain responses and decreased the number of neutrophils.

CONCLUSION

The present study showed anti-inflammatory and antinociceptive activities for crocin, safranal and diclofenac in carrageenan model of local inflammation and inflammatory pain.

Authors+Show Affiliations

Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia 57153-1177, Iran. e_tamaddonfard@yahoo.com and e.tamaddonfard@urmia.ac.ir.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

24399723

Citation

Tamaddonfard, Esmaeal, et al. "Comparison of the Effects of Crocin, Safranal and Diclofenac On Local Inflammation and Inflammatory Pain Responses Induced By Carrageenan in Rats." Pharmacological Reports : PR, vol. 65, no. 5, 2013, pp. 1272-80.
Tamaddonfard E, Farshid AA, Eghdami K, et al. Comparison of the effects of crocin, safranal and diclofenac on local inflammation and inflammatory pain responses induced by carrageenan in rats. Pharmacol Rep. 2013;65(5):1272-80.
Tamaddonfard, E., Farshid, A. A., Eghdami, K., Samadi, F., & Erfanparast, A. (2013). Comparison of the effects of crocin, safranal and diclofenac on local inflammation and inflammatory pain responses induced by carrageenan in rats. Pharmacological Reports : PR, 65(5), 1272-80.
Tamaddonfard E, et al. Comparison of the Effects of Crocin, Safranal and Diclofenac On Local Inflammation and Inflammatory Pain Responses Induced By Carrageenan in Rats. Pharmacol Rep. 2013;65(5):1272-80. PubMed PMID: 24399723.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of the effects of crocin, safranal and diclofenac on local inflammation and inflammatory pain responses induced by carrageenan in rats. AU - Tamaddonfard,Esmaeal, AU - Farshid,Amir-Abbas, AU - Eghdami,Karim, AU - Samadi,Farzad, AU - Erfanparast,Amir, PY - 2012/11/24/received PY - 2013/05/13/revised PY - 2014/1/9/entrez PY - 2014/1/9/pubmed PY - 2014/8/26/medline SP - 1272 EP - 80 JF - Pharmacological reports : PR JO - Pharmacol Rep VL - 65 IS - 5 N2 - BACKGROUND: Crocin and safranal are the active substances of saffron and have many biological properties. In the present study, we compared the effects of crocin, safranal and diclofenac on local inflammation and its induced pain in rats. METHODS: Local inflammation was induced by intraplantar (ipl) injection of carrageenan (100 μl, 2%). Paw thickness was measured before and after carrageenan injection. Inflammatory pain responses including cold allodynia, mechanical allodynia and hyperalgesia were assessed using acetone spray and von Frey filament tests, respectively. The number of neutrophils in inflammatory zone was counted 6.5 h after injection of carrageenan. RESULTS: Carrageenan produced edema, cold allodynia, mechanical allodynia and hyperalgesia and caused neutrophil infiltration in paw tissues. Crocin at doses of 25, 50 and 100 mg/kg, safranal at doses of 0.5, 1 and 2 mg/kg and diclofenac (as a reference drug) at a dose of 10 mg/kg attenuated edema, suppressed inflammatory pain responses and decreased the number of neutrophils. CONCLUSION: The present study showed anti-inflammatory and antinociceptive activities for crocin, safranal and diclofenac in carrageenan model of local inflammation and inflammatory pain. SN - 1734-1140 UR - https://www.unboundmedicine.com/medline/citation/24399723/Comparison_of_the_effects_of_crocin_safranal_and_diclofenac_on_local_inflammation_and_inflammatory_pain_responses_induced_by_carrageenan_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1734-1140(13)71485-3 DB - PRIME DP - Unbound Medicine ER -