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Multiple ventricular septal defects: a new strategy.
Front Pediatr 2013; 1:16FP

Abstract

INTRODUCTION

A multicenter prospective study was conducted to evaluate a new strategy for multiple Ventricular Septal Defects (VSDs).

MATERIALS AND METHODS

From 2004 to 2012 17 consecutive children (3 premature, 14 infants), mean age 3.2 months (9 days-9 months), mean body weight 4.2 kg (3.1-6.1 kg), with multiple VSDs underwent Pulmonary Artery Banding (PAB) with an adjustable FloWatch-PAB(®). Associated cardiac anomalies included patent ductus arteriosus (1), aortic coarctation (2), hypoplastic aortic arch (2), and left isomerism (3). Five patients (5/17 = 29.4%) required pre-operative mechanical ventilation, with a mean duration of 64 days (7-240 days)

RESULTS

There were no early or late deaths during a mean follow-up of 48 months (7-98 months), with either FloWatch removal or last observation as end-points. FloWatch-PAB(®) adjustments were required in all patients: a mean of 4.8 times/patient (2-9) to tighten the PAB, and a mean of 1.1 times/patient (0-3) to release the PAB with the patient's growth. After a mean interval of 29 months (8-69 months) 10/17 (59%) patients underwent re-operation: 7/10 PAB removal, with closure of a remaining unrestrictive VSD in 6 (peri-membranous in 3 patients, mid-muscular in 2, and inlet in 1) and Damus-Kaye-Stansel, bi-directional Glenn, and atrial septectomy in 1; 3/9 patients required only PAB removal. All muscular multiple VSDs had closed in all 10 patients. PA reconstruction was required in 1/10 patient. In 5/7 of the remaining patients with the PAB still in situ, all muscular VSDs had already closed. The only 2 patients with persistent muscular multiple VSDs are the 2 patients with the shortest follow-up.

CONCLUSION

This reproducible new strategy with an adjustable PAB simplifies the management of infants with multiple VSDs and provides the following advantages: (a) good results (0% mortality), delayed surgery with a high incidence (15/17 = 88%) of spontaneous closure of multiple muscular VSDs, and facilitated closure of residual unrestrictive VSD (peri-membranous, mid-muscular, or inlet) at an older age and higher body weight; PAB with FloWatch-PAB(®) and its subsequent removal can potentially be the only procedure required for Swiss cheese multiple VSDs without an associated peri-membranous unrestrictive VSD.

Authors+Show Affiliations

King Fahad Medical City Riyadh, Saudi Arabia.Alder Hey Children's NHS Foundation Trust Liverpool, UK.Alder Hey Children's NHS Foundation Trust Liverpool, UK.Alder Hey Children's NHS Foundation Trust Liverpool, UK.Alder Hey Children's NHS Foundation Trust Liverpool, UK.Alder Hey Children's NHS Foundation Trust Liverpool, UK.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24400262

Citation

Corno, Antonio F., et al. "Multiple Ventricular Septal Defects: a New Strategy." Frontiers in Pediatrics, vol. 1, 2013, p. 16.
Corno AF, Kandakure PR, Dhannapuneni RR, et al. Multiple ventricular septal defects: a new strategy. Front Pediatr. 2013;1:16.
Corno, A. F., Kandakure, P. R., Dhannapuneni, R. R., Gladman, G., Venugopal, P., & Alphonso, N. (2013). Multiple ventricular septal defects: a new strategy. Frontiers in Pediatrics, 1, p. 16. doi:10.3389/fped.2013.00016.
Corno AF, et al. Multiple Ventricular Septal Defects: a New Strategy. Front Pediatr. 2013;1:16. PubMed PMID: 24400262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multiple ventricular septal defects: a new strategy. AU - Corno,Antonio F, AU - Kandakure,Pramod R, AU - Dhannapuneni,Ramana Rao V, AU - Gladman,Gordon, AU - Venugopal,Prem, AU - Alphonso,Nelson, Y1 - 2013/07/31/ PY - 2013/05/23/received PY - 2013/07/16/accepted PY - 2014/1/9/entrez PY - 2014/1/9/pubmed PY - 2014/1/9/medline KW - congenital heart defects KW - multiple ventricular septal defects KW - palliation KW - pulmonary artery banding KW - surgical repair SP - 16 EP - 16 JF - Frontiers in pediatrics JO - Front Pediatr VL - 1 N2 - INTRODUCTION: A multicenter prospective study was conducted to evaluate a new strategy for multiple Ventricular Septal Defects (VSDs). MATERIALS AND METHODS: From 2004 to 2012 17 consecutive children (3 premature, 14 infants), mean age 3.2 months (9 days-9 months), mean body weight 4.2 kg (3.1-6.1 kg), with multiple VSDs underwent Pulmonary Artery Banding (PAB) with an adjustable FloWatch-PAB(®). Associated cardiac anomalies included patent ductus arteriosus (1), aortic coarctation (2), hypoplastic aortic arch (2), and left isomerism (3). Five patients (5/17 = 29.4%) required pre-operative mechanical ventilation, with a mean duration of 64 days (7-240 days) RESULTS: There were no early or late deaths during a mean follow-up of 48 months (7-98 months), with either FloWatch removal or last observation as end-points. FloWatch-PAB(®) adjustments were required in all patients: a mean of 4.8 times/patient (2-9) to tighten the PAB, and a mean of 1.1 times/patient (0-3) to release the PAB with the patient's growth. After a mean interval of 29 months (8-69 months) 10/17 (59%) patients underwent re-operation: 7/10 PAB removal, with closure of a remaining unrestrictive VSD in 6 (peri-membranous in 3 patients, mid-muscular in 2, and inlet in 1) and Damus-Kaye-Stansel, bi-directional Glenn, and atrial septectomy in 1; 3/9 patients required only PAB removal. All muscular multiple VSDs had closed in all 10 patients. PA reconstruction was required in 1/10 patient. In 5/7 of the remaining patients with the PAB still in situ, all muscular VSDs had already closed. The only 2 patients with persistent muscular multiple VSDs are the 2 patients with the shortest follow-up. CONCLUSION: This reproducible new strategy with an adjustable PAB simplifies the management of infants with multiple VSDs and provides the following advantages: (a) good results (0% mortality), delayed surgery with a high incidence (15/17 = 88%) of spontaneous closure of multiple muscular VSDs, and facilitated closure of residual unrestrictive VSD (peri-membranous, mid-muscular, or inlet) at an older age and higher body weight; PAB with FloWatch-PAB(®) and its subsequent removal can potentially be the only procedure required for Swiss cheese multiple VSDs without an associated peri-membranous unrestrictive VSD. SN - 2296-2360 UR - https://www.unboundmedicine.com/medline/citation/24400262/Multiple_ventricular_septal_defects:_a_new_strategy_ L2 - https://doi.org/10.3389/fped.2013.00016 DB - PRIME DP - Unbound Medicine ER -