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Correlation of foveal photoreceptor integrity with visual outcome in idiopathic epiretinal membrane.
Curr Eye Res. 2014 Jun; 39(6):626-33.CE

Abstract

PURPOSE

To evaluate the correlation of foveal photoreceptor integrity with visual outcome in patients undergoing idiopathic epiretinal membrane (ERM) surgery using spectral domain optical coherence tomography (SD-OCT).

MATERIALS AND METHODS

Forty-three eyes of 43 patients were examined by SD-OCT before and at 1 and 6 months after vitrectomy for idiopathic ERM. Patients were divided into two groups based on the preoperative integrity of photoreceptor inner and outer segment junction (IS/OS) - Group I, intact IS/OS and Group D, disrupted IS/OS. Where present, disrupted length of IS/OS was measured, and the association between disrupted length of IS/OS and foveal thickness with best corrected visual acuity (BCVA) was evaluated.

RESULTS

There were 27 eyes with an intact IS/OS (Group I) and 16 eyes with a disrupted IS/OS (Group D). Patients in Group I had significantly better postoperative BCVA and greater improvement than those in Group D at 6 months after surgery (p = 0.001 and p = 0.030, respectively). By 6 months after surgery, the disrupted length of IS/OS observed preoperatively in Group D had decreased significantly (p = 0.007). The disrupted length of IS/OS before and at 6 months after the surgery in Group D showed a positive correlation with BCVA (r = 0.632 and p = 0.009; r = 0.658 and p = 0.006, respectively). Foveal thickness did not correlate significantly with preoperative and postoperative BCVA.

CONCLUSIONS

Preoperative disruption of foveal photoreceptors can be restored after ERM surgery. The preoperative integrity of foveal photoreceptors may be a clinically significant prognostic factor for visual recovery in patients with idiopathic ERM.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Kim HJ
Department of Ophthalmology, Konkuk University Medical Center, Konkuk University School of Medicine , Seoul , Republic of Korea.
Kang JW
No affiliation info available
Chung H
No affiliation info available
Kim HC
No affiliation info available

MeSH

AgedEpiretinal MembraneFemaleFovea CentralisHumansLens Implantation, IntraocularMalePhacoemulsificationPostoperative PeriodPreoperative PeriodRecovery of FunctionRetinal Photoreceptor Cell Inner SegmentRetinal Photoreceptor Cell Outer SegmentRetrospective StudiesTomography, Optical CoherenceVision DisordersVisual AcuityVitrectomy

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24401121

Citation

Kim, Hyung Jun, et al. "Correlation of Foveal Photoreceptor Integrity With Visual Outcome in Idiopathic Epiretinal Membrane." Current Eye Research, vol. 39, no. 6, 2014, pp. 626-33.
Kim HJ, Kang JW, Chung H, et al. Correlation of foveal photoreceptor integrity with visual outcome in idiopathic epiretinal membrane. Curr Eye Res. 2014;39(6):626-33.
Kim, H. J., Kang, J. W., Chung, H., & Kim, H. C. (2014). Correlation of foveal photoreceptor integrity with visual outcome in idiopathic epiretinal membrane. Current Eye Research, 39(6), 626-33. https://doi.org/10.3109/02713683.2013.860990
Kim HJ, et al. Correlation of Foveal Photoreceptor Integrity With Visual Outcome in Idiopathic Epiretinal Membrane. Curr Eye Res. 2014;39(6):626-33. PubMed PMID: 24401121.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation of foveal photoreceptor integrity with visual outcome in idiopathic epiretinal membrane. AU - Kim,Hyung Jun, AU - Kang,Joon-Won, AU - Chung,Hyewon, AU - Kim,Hyung Chan, Y1 - 2014/01/08/ PY - 2014/1/10/entrez PY - 2014/1/10/pubmed PY - 2014/10/30/medline SP - 626 EP - 33 JF - Current eye research JO - Curr Eye Res VL - 39 IS - 6 N2 - PURPOSE: To evaluate the correlation of foveal photoreceptor integrity with visual outcome in patients undergoing idiopathic epiretinal membrane (ERM) surgery using spectral domain optical coherence tomography (SD-OCT). MATERIALS AND METHODS: Forty-three eyes of 43 patients were examined by SD-OCT before and at 1 and 6 months after vitrectomy for idiopathic ERM. Patients were divided into two groups based on the preoperative integrity of photoreceptor inner and outer segment junction (IS/OS) - Group I, intact IS/OS and Group D, disrupted IS/OS. Where present, disrupted length of IS/OS was measured, and the association between disrupted length of IS/OS and foveal thickness with best corrected visual acuity (BCVA) was evaluated. RESULTS: There were 27 eyes with an intact IS/OS (Group I) and 16 eyes with a disrupted IS/OS (Group D). Patients in Group I had significantly better postoperative BCVA and greater improvement than those in Group D at 6 months after surgery (p = 0.001 and p = 0.030, respectively). By 6 months after surgery, the disrupted length of IS/OS observed preoperatively in Group D had decreased significantly (p = 0.007). The disrupted length of IS/OS before and at 6 months after the surgery in Group D showed a positive correlation with BCVA (r = 0.632 and p = 0.009; r = 0.658 and p = 0.006, respectively). Foveal thickness did not correlate significantly with preoperative and postoperative BCVA. CONCLUSIONS: Preoperative disruption of foveal photoreceptors can be restored after ERM surgery. The preoperative integrity of foveal photoreceptors may be a clinically significant prognostic factor for visual recovery in patients with idiopathic ERM. SN - 1460-2202 UR - https://www.unboundmedicine.com/medline/citation/24401121/Correlation_of_foveal_photoreceptor_integrity_with_visual_outcome_in_idiopathic_epiretinal_membrane_ DB - PRIME DP - Unbound Medicine ER -