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Associations of matrix metalloproteinase-9 and monocyte chemoattractant protein-1 concentrations with carotid atherosclerosis, based on measurements of plaque and intima-media thickness.
Atherosclerosis 2014; 232(1):199-203A

Abstract

PURPOSE

To examine associations of matrix metalloproteinase-9 (MMP-9) and monocyte chemoattractant protein-1 (MCP-1) concentrations with the severity of carotid atherosclerosis, based on measurements of carotid plaque and intima-media thickness (IMT).

METHODS

This cross-sectional study included 116 stroke-free participants (45.7% males, 54.3% females; mean age, 64.73 ± 14.53 years). Serum MMP-9 and MCP-1 concentrations were measured, and plaque morphology, including total plaque score (PS), plaque stability, and IMT, was assessed ultrasonographically. Participants were grouped according to total PS (0, 1-2, ≥ 3), plaque stability (no plaque, stable, unstable) and IMT tertiles (<0.8 mm, 0.8-1 mm, >1 mm). Multinomial logistic regression models were used to assess the associations of MMP-9 and MCP-1 concentrations with plaque and IMT values after adjusting for vascular risk factors.

RESULTS

MMP-9 quartiles (vs. quartile 1) were significantly associated with a greater prevalence of plaque instability [Q2: odds ratio (OR) = 5.13, 95% confidence interval (CI) = 1.01-24.9, p = 0.042; Q3: OR = 15.5, 95% CI = 3.1-78.1, p = 0.001; Q4: OR = 13.2, 95% CI = 2.7-64.97, p = 0.001] and high total PS (Q3: OR = 10.02, 95% CI = 1.5-65.33, p = 0.016; Q4: OR = 21.5, 95% CI = 3.5-132.1, p = 0.001). MCP-1 concentration was significantly associated with IMT (OR = 22.94, 95% CI = 2.14-245.66, p = 0.01).

CONCLUSIONS

Elevated serum MMP-9 concentration was independently associated with high total carotid artery PS, plaque instability, and large IMT value. MCP-1 concentration was independently associated with IMT, but not with plaque morphology.

Authors+Show Affiliations

Department of Neurology, the Second Affiliated Hospital of Chong Qing Medical University, Number 76, LinJiang Road, YuZhong District, 400010 Chong Qing, China.Department of Neurology, the Second Affiliated Hospital of Chong Qing Medical University, Number 76, LinJiang Road, YuZhong District, 400010 Chong Qing, China.Department of Neurology, the Second Affiliated Hospital of Chong Qing Medical University, Number 76, LinJiang Road, YuZhong District, 400010 Chong Qing, China.Department of Neurology, the Second Affiliated Hospital of Chong Qing Medical University, Number 76, LinJiang Road, YuZhong District, 400010 Chong Qing, China.Department of Neurology, the Second Affiliated Hospital of Chong Qing Medical University, Number 76, LinJiang Road, YuZhong District, 400010 Chong Qing, China.Department of Neurology, the Second Affiliated Hospital of Chong Qing Medical University, Number 76, LinJiang Road, YuZhong District, 400010 Chong Qing, China.Department of Neurology, the Second Affiliated Hospital of Chong Qing Medical University, Number 76, LinJiang Road, YuZhong District, 400010 Chong Qing, China.Department of Neurology, the Second Affiliated Hospital of Chong Qing Medical University, Number 76, LinJiang Road, YuZhong District, 400010 Chong Qing, China.Department of Neurology, the Second Affiliated Hospital of Chong Qing Medical University, Number 76, LinJiang Road, YuZhong District, 400010 Chong Qing, China.Department of Neurology, the Second Affiliated Hospital of Chong Qing Medical University, Number 76, LinJiang Road, YuZhong District, 400010 Chong Qing, China. Electronic address: lifen_chen@163.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24401238

Citation

Tan, Changhong, et al. "Associations of Matrix Metalloproteinase-9 and Monocyte Chemoattractant Protein-1 Concentrations With Carotid Atherosclerosis, Based On Measurements of Plaque and Intima-media Thickness." Atherosclerosis, vol. 232, no. 1, 2014, pp. 199-203.
Tan C, Liu Y, Li W, et al. Associations of matrix metalloproteinase-9 and monocyte chemoattractant protein-1 concentrations with carotid atherosclerosis, based on measurements of plaque and intima-media thickness. Atherosclerosis. 2014;232(1):199-203.
Tan, C., Liu, Y., Li, W., Deng, F., Liu, X., Wang, X., ... Chen, L. (2014). Associations of matrix metalloproteinase-9 and monocyte chemoattractant protein-1 concentrations with carotid atherosclerosis, based on measurements of plaque and intima-media thickness. Atherosclerosis, 232(1), pp. 199-203. doi:10.1016/j.atherosclerosis.2013.11.040.
Tan C, et al. Associations of Matrix Metalloproteinase-9 and Monocyte Chemoattractant Protein-1 Concentrations With Carotid Atherosclerosis, Based On Measurements of Plaque and Intima-media Thickness. Atherosclerosis. 2014;232(1):199-203. PubMed PMID: 24401238.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of matrix metalloproteinase-9 and monocyte chemoattractant protein-1 concentrations with carotid atherosclerosis, based on measurements of plaque and intima-media thickness. AU - Tan,Changhong, AU - Liu,Yi, AU - Li,Weina, AU - Deng,Fen, AU - Liu,Xi, AU - Wang,Xin, AU - Gui,Yuejiang, AU - Qin,Lu, AU - Hu,Changlin, AU - Chen,Lifen, Y1 - 2013/11/25/ PY - 2013/07/11/received PY - 2013/11/06/revised PY - 2013/11/06/accepted PY - 2014/1/10/entrez PY - 2014/1/10/pubmed PY - 2014/9/17/medline KW - Carotid atherosclerosis KW - Intima–media thickness KW - Plaque score KW - Serum matrix metalloproteinase-9 KW - Serum monocyte chemoattractant protein-1 SP - 199 EP - 203 JF - Atherosclerosis JO - Atherosclerosis VL - 232 IS - 1 N2 - PURPOSE: To examine associations of matrix metalloproteinase-9 (MMP-9) and monocyte chemoattractant protein-1 (MCP-1) concentrations with the severity of carotid atherosclerosis, based on measurements of carotid plaque and intima-media thickness (IMT). METHODS: This cross-sectional study included 116 stroke-free participants (45.7% males, 54.3% females; mean age, 64.73 ± 14.53 years). Serum MMP-9 and MCP-1 concentrations were measured, and plaque morphology, including total plaque score (PS), plaque stability, and IMT, was assessed ultrasonographically. Participants were grouped according to total PS (0, 1-2, ≥ 3), plaque stability (no plaque, stable, unstable) and IMT tertiles (<0.8 mm, 0.8-1 mm, >1 mm). Multinomial logistic regression models were used to assess the associations of MMP-9 and MCP-1 concentrations with plaque and IMT values after adjusting for vascular risk factors. RESULTS: MMP-9 quartiles (vs. quartile 1) were significantly associated with a greater prevalence of plaque instability [Q2: odds ratio (OR) = 5.13, 95% confidence interval (CI) = 1.01-24.9, p = 0.042; Q3: OR = 15.5, 95% CI = 3.1-78.1, p = 0.001; Q4: OR = 13.2, 95% CI = 2.7-64.97, p = 0.001] and high total PS (Q3: OR = 10.02, 95% CI = 1.5-65.33, p = 0.016; Q4: OR = 21.5, 95% CI = 3.5-132.1, p = 0.001). MCP-1 concentration was significantly associated with IMT (OR = 22.94, 95% CI = 2.14-245.66, p = 0.01). CONCLUSIONS: Elevated serum MMP-9 concentration was independently associated with high total carotid artery PS, plaque instability, and large IMT value. MCP-1 concentration was independently associated with IMT, but not with plaque morphology. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/24401238/Associations_of_matrix_metalloproteinase_9_and_monocyte_chemoattractant_protein_1_concentrations_with_carotid_atherosclerosis_based_on_measurements_of_plaque_and_intima_media_thickness_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(13)00691-6 DB - PRIME DP - Unbound Medicine ER -