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Electrochemical oxidation and electroanalytical determination of xylitol at a boron-doped diamond electrode.
Talanta. 2014 Feb; 119:509-16.T

Abstract

Xylitol is a reduced sugar with anticariogenic properties used by insulin-dependent diabetics, and which has attracted great attention of the pharmaceutical, cosmetics, food and dental industries. The detection of xylitol in different matrices is generally based on separation techniques. Alternatively, in this paper, the application of a boron-doped diamond (BDD) electrode allied to differing voltammetric techniques is presented to study the electrochemical behavior of xylitol, and to develop an analytical methodology for its determination in mouthwash. Xylitol undergoes two oxidation steps in an irreversible diffusion-controlled process (D=5.05 × 10(-5)cm(2)s(-1)). Differential pulse voltammetry studies revealed that the oxidation mechanism for peaks P1 (3.4 ≤ pH ≤ 8.0), and P2 (6.0 ≤ pH ≤ 9.0) involves transfer of 1H(+)/1e(-), and 1e(-) alone, respectively. The oxidation process P1 is mediated by the (•)OH generated at the BDD hydrogen-terminated surface. The maximum peak current was obtained at a pH of 7.0, and the electroanalytical method developed, (employing square wave voltammetry) yielded low detection (1.3 × 10(-6) mol L(-1)), and quantification (4.5 × 10(-6) mol L(-1)) limits, associated with good levels of repeatability (4.7%), and reproducibility (5.3%); thus demonstrating the viability of the methodology for detection of xylitol in biological samples containing low concentrations.

Authors+Show Affiliations

Universidade Federal da Paraíba, Centro de Ciências Exatas e da Natureza, Departamento de Química, P.O. Box 5093, 58051-970 João Pessoa, PB, Brazil.Universidade Federal da Paraíba, Centro de Ciências Exatas e da Natureza, Departamento de Química, P.O. Box 5093, 58051-970 João Pessoa, PB, Brazil.Universidade Federal da Paraíba, Centro de Ciências Exatas e da Natureza, Departamento de Química, P.O. Box 5093, 58051-970 João Pessoa, PB, Brazil.Universidade Federal da Paraíba, Centro de Ciências Exatas e da Natureza, Departamento de Química, P.O. Box 5093, 58051-970 João Pessoa, PB, Brazil.Universidade Federal da Paraíba, Centro de Ciências Exatas e da Natureza, Departamento de Química, P.O. Box 5093, 58051-970 João Pessoa, PB, Brazil; Universidade Federal da Paraíba, Centro de Ciências Agrárias, Departamento de Ciências Fundamentais e Sociais, 58397-000 Areia, PB, Brazil.Universidade Federal da Paraíba, Centro de Ciências Exatas e da Natureza, Departamento de Química, P.O. Box 5093, 58051-970 João Pessoa, PB, Brazil.Instituto de Tecnologia e Pesquisa/Programa de Pós-graduação em Engenharia de Processos, Universidade Tiradentes, Avenida Murilo Dantas, 300, Farolândia, 49032-490 Aracaju, SE, Brazil.Universidade Federal da Paraíba, Centro de Ciências Exatas e da Natureza, Departamento de Química, P.O. Box 5093, 58051-970 João Pessoa, PB, Brazil. Electronic address: laqa@quimica.ufpb.br.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24401449

Citation

Lourenço, Anabel S., et al. "Electrochemical Oxidation and Electroanalytical Determination of Xylitol at a Boron-doped Diamond Electrode." Talanta, vol. 119, 2014, pp. 509-16.
Lourenço AS, Sanches FA, Magalhães RR, et al. Electrochemical oxidation and electroanalytical determination of xylitol at a boron-doped diamond electrode. Talanta. 2014;119:509-16.
Lourenço, A. S., Sanches, F. A., Magalhães, R. R., Costa, D. J., Ribeiro, W. F., Bichinho, K. M., Salazar-Banda, G. R., & Araújo, M. C. (2014). Electrochemical oxidation and electroanalytical determination of xylitol at a boron-doped diamond electrode. Talanta, 119, 509-16. https://doi.org/10.1016/j.talanta.2013.11.030
Lourenço AS, et al. Electrochemical Oxidation and Electroanalytical Determination of Xylitol at a Boron-doped Diamond Electrode. Talanta. 2014;119:509-16. PubMed PMID: 24401449.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrochemical oxidation and electroanalytical determination of xylitol at a boron-doped diamond electrode. AU - Lourenço,Anabel S, AU - Sanches,Fátima A C, AU - Magalhães,Renata R, AU - Costa,Daniel J E, AU - Ribeiro,Williame F, AU - Bichinho,Kátia M, AU - Salazar-Banda,Giancarlo R, AU - Araújo,Mário C U, Y1 - 2013/11/27/ PY - 2013/06/13/received PY - 2013/11/06/revised PY - 2013/11/08/accepted PY - 2014/1/10/entrez PY - 2014/1/10/pubmed PY - 2014/9/3/medline KW - Boron-doped diamond KW - Mouthwash KW - Square wave voltammetry KW - Xylitol SP - 509 EP - 16 JF - Talanta JO - Talanta VL - 119 N2 - Xylitol is a reduced sugar with anticariogenic properties used by insulin-dependent diabetics, and which has attracted great attention of the pharmaceutical, cosmetics, food and dental industries. The detection of xylitol in different matrices is generally based on separation techniques. Alternatively, in this paper, the application of a boron-doped diamond (BDD) electrode allied to differing voltammetric techniques is presented to study the electrochemical behavior of xylitol, and to develop an analytical methodology for its determination in mouthwash. Xylitol undergoes two oxidation steps in an irreversible diffusion-controlled process (D=5.05 × 10(-5)cm(2)s(-1)). Differential pulse voltammetry studies revealed that the oxidation mechanism for peaks P1 (3.4 ≤ pH ≤ 8.0), and P2 (6.0 ≤ pH ≤ 9.0) involves transfer of 1H(+)/1e(-), and 1e(-) alone, respectively. The oxidation process P1 is mediated by the (•)OH generated at the BDD hydrogen-terminated surface. The maximum peak current was obtained at a pH of 7.0, and the electroanalytical method developed, (employing square wave voltammetry) yielded low detection (1.3 × 10(-6) mol L(-1)), and quantification (4.5 × 10(-6) mol L(-1)) limits, associated with good levels of repeatability (4.7%), and reproducibility (5.3%); thus demonstrating the viability of the methodology for detection of xylitol in biological samples containing low concentrations. SN - 1873-3573 UR - https://www.unboundmedicine.com/medline/citation/24401449/Electrochemical_oxidation_and_electroanalytical_determination_of_xylitol_at_a_boron_doped_diamond_electrode_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-9140(13)00907-7 DB - PRIME DP - Unbound Medicine ER -