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Mitochondrial fragmentation is an important cellular event induced by ruthenium(II) polypyridyl complexes in osteosarcoma cells.
ChemMedChem. 2014 Apr; 9(4):714-8.C

Abstract

A series of ruthenium(II) polypyridyl complexes were synthesized and evaluated for their in vitro anticancer activities. The results showed that ruthenium polypyridyl complexes, especially [Ru(bpy)2 (p-tFPIP)](2+) (2 a; bpy=bipyridine, tFPIP=2-(2-trifluoromethane phenyl)imidazole[4,5-f][1,10]phenanthroline), exhibited novel anticancer activity against human cancer cell lines, but with less toxicity to a human normal cell line. The results of flow cytometry and caspase activities analysis indicated that the 2 a-induced growth inhibition against MG-63 osteosarcoma cells was mainly caused by mitochondria-mediated apoptosis. DNA fragmentation and nuclear condensation as detected by TUNEL-DAPI co-staining further confirmed 2 a-induced apoptotic cell death. Further, fluorescence imaging revealed that ruthenium(II) polypyridyl complexes could target mitochondria to induce mitochondrial fragmentation, accompanied by depletion of mitochondrial membrane potential. Taken together, these findings suggest a potential application of theses ruthenium(II) complexes in the treatment of cancers.

Authors+Show Affiliations

Orthopedics Department, Guangdong Provincial Hospital of Traditional Chinese Medicine, 111 Dade Road, Guangzhou 510120, Guangdong (China).No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24403015

Citation

Du, Yanxin, et al. "Mitochondrial Fragmentation Is an Important Cellular Event Induced By ruthenium(II) Polypyridyl Complexes in Osteosarcoma Cells." ChemMedChem, vol. 9, no. 4, 2014, pp. 714-8.
Du Y, Fu X, Li H, et al. Mitochondrial fragmentation is an important cellular event induced by ruthenium(II) polypyridyl complexes in osteosarcoma cells. ChemMedChem. 2014;9(4):714-8.
Du, Y., Fu, X., Li, H., Chen, B., Guo, Y., Su, G., Zhang, H., Ning, F., Lin, Y., Mei, W., & Chen, T. (2014). Mitochondrial fragmentation is an important cellular event induced by ruthenium(II) polypyridyl complexes in osteosarcoma cells. ChemMedChem, 9(4), 714-8. https://doi.org/10.1002/cmdc.201300379
Du Y, et al. Mitochondrial Fragmentation Is an Important Cellular Event Induced By ruthenium(II) Polypyridyl Complexes in Osteosarcoma Cells. ChemMedChem. 2014;9(4):714-8. PubMed PMID: 24403015.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mitochondrial fragmentation is an important cellular event induced by ruthenium(II) polypyridyl complexes in osteosarcoma cells. AU - Du,Yanxin, AU - Fu,Xiaoyan, AU - Li,Hong, AU - Chen,Bolai, AU - Guo,Yuhai, AU - Su,Guoyi, AU - Zhang,Hu, AU - Ning,Feipeng, AU - Lin,Yongpeng, AU - Mei,Wenjie, AU - Chen,Tianfeng, Y1 - 2014/01/08/ PY - 2013/09/22/received PY - 2014/1/10/entrez PY - 2014/1/10/pubmed PY - 2014/12/17/medline KW - anticancer agents KW - apoptosis KW - mitochondria membrane potential KW - mitochondrial fragmentation KW - ruthenium polypyridyl complexes SP - 714 EP - 8 JF - ChemMedChem JO - ChemMedChem VL - 9 IS - 4 N2 - A series of ruthenium(II) polypyridyl complexes were synthesized and evaluated for their in vitro anticancer activities. The results showed that ruthenium polypyridyl complexes, especially [Ru(bpy)2 (p-tFPIP)](2+) (2 a; bpy=bipyridine, tFPIP=2-(2-trifluoromethane phenyl)imidazole[4,5-f][1,10]phenanthroline), exhibited novel anticancer activity against human cancer cell lines, but with less toxicity to a human normal cell line. The results of flow cytometry and caspase activities analysis indicated that the 2 a-induced growth inhibition against MG-63 osteosarcoma cells was mainly caused by mitochondria-mediated apoptosis. DNA fragmentation and nuclear condensation as detected by TUNEL-DAPI co-staining further confirmed 2 a-induced apoptotic cell death. Further, fluorescence imaging revealed that ruthenium(II) polypyridyl complexes could target mitochondria to induce mitochondrial fragmentation, accompanied by depletion of mitochondrial membrane potential. Taken together, these findings suggest a potential application of theses ruthenium(II) complexes in the treatment of cancers. SN - 1860-7187 UR - https://www.unboundmedicine.com/medline/citation/24403015/Mitochondrial_fragmentation_is_an_important_cellular_event_induced_by_ruthenium_II__polypyridyl_complexes_in_osteosarcoma_cells_ L2 - https://doi.org/10.1002/cmdc.201300379 DB - PRIME DP - Unbound Medicine ER -