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Prognostic significance of Ki-67 in chemotherapy-naive breast cancer patients with 10-year follow-up.
Anticancer Res. 2014 Jan; 34(1):259-68.AR

Abstract

BACKGROUND/AIM

In order to define accurate survival outcome in breast cancer, 10-year follow-up is required and such long-term survival information are few and difficult to gather.

PATIENTS AND METHODS

We recruited 253 breast cancer patients who undertook operation with no prior chemotherapy. Ten-year survival outcomes were evaluated by clinicopathological factors.

RESULTS

Significant univariate prognostic factors were: T factor, N factor, preoperative values of tumor markers, and biological factors. T-factor, CEA, hormone receptor, and Ki-67 were the final independent prognostic factors of recurrence-free survival through multivariate analysis. The Luminal A group except for the Ki-67-positive cases showed the best survival outcomes, while the HER2-positive or triple-negative (TN) groups showed worse prognosis than the Luminal A group, and Ki-67 was shown to be an excellent prognostic factor in each stage (p<0.01).

CONCLUSION

Ki-67 has a great potential as a prognostic biomarker while prognostic information of this sort could be beneficial for development of novel therapeutic strategies.

Authors+Show Affiliations

FACS, Department of Surgery, Kitasato University School of Medicine, 1-15-1, Kitasato, Minami-ku, Sagamihara, Japan. gekaw@med.kitasato-u.ac.jp.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24403472

Citation

Nishimiya, Hiroshi, et al. "Prognostic Significance of Ki-67 in Chemotherapy-naive Breast Cancer Patients With 10-year Follow-up." Anticancer Research, vol. 34, no. 1, 2014, pp. 259-68.
Nishimiya H, Kosaka Y, Yamashita K, et al. Prognostic significance of Ki-67 in chemotherapy-naive breast cancer patients with 10-year follow-up. Anticancer Res. 2014;34(1):259-68.
Nishimiya, H., Kosaka, Y., Yamashita, K., Minatani, N., Kikuchi, M., Ema, A., Nakamura, K., Waraya, M., Sengoku, N., Tanino, H., Kuranami, M., Watanabe, M., & Masahiko, W. (2014). Prognostic significance of Ki-67 in chemotherapy-naive breast cancer patients with 10-year follow-up. Anticancer Research, 34(1), 259-68.
Nishimiya H, et al. Prognostic Significance of Ki-67 in Chemotherapy-naive Breast Cancer Patients With 10-year Follow-up. Anticancer Res. 2014;34(1):259-68. PubMed PMID: 24403472.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic significance of Ki-67 in chemotherapy-naive breast cancer patients with 10-year follow-up. AU - Nishimiya,Hiroshi, AU - Kosaka,Yoshimasa, AU - Yamashita,Keishi, AU - Minatani,Naoko, AU - Kikuchi,Mariko, AU - Ema,Akira, AU - Nakamura,Kazunori, AU - Waraya,Mina, AU - Sengoku,Norihiko, AU - Tanino,Hirokazu, AU - Kuranami,Masaru, AU - Watanabe,Masahiko, AU - Masahiko,Watanabe, PY - 2014/1/10/entrez PY - 2014/1/10/pubmed PY - 2014/3/26/medline KW - Breast cancer KW - chemotherapy-naïve patients KW - clinicopathological parameters KW - multivariate analysis SP - 259 EP - 68 JF - Anticancer research JO - Anticancer Res VL - 34 IS - 1 N2 - BACKGROUND/AIM: In order to define accurate survival outcome in breast cancer, 10-year follow-up is required and such long-term survival information are few and difficult to gather. PATIENTS AND METHODS: We recruited 253 breast cancer patients who undertook operation with no prior chemotherapy. Ten-year survival outcomes were evaluated by clinicopathological factors. RESULTS: Significant univariate prognostic factors were: T factor, N factor, preoperative values of tumor markers, and biological factors. T-factor, CEA, hormone receptor, and Ki-67 were the final independent prognostic factors of recurrence-free survival through multivariate analysis. The Luminal A group except for the Ki-67-positive cases showed the best survival outcomes, while the HER2-positive or triple-negative (TN) groups showed worse prognosis than the Luminal A group, and Ki-67 was shown to be an excellent prognostic factor in each stage (p<0.01). CONCLUSION: Ki-67 has a great potential as a prognostic biomarker while prognostic information of this sort could be beneficial for development of novel therapeutic strategies. SN - 1791-7530 UR - https://www.unboundmedicine.com/medline/citation/24403472/Prognostic_significance_of_Ki_67_in_chemotherapy_naive_breast_cancer_patients_with_10_year_follow_up_ L2 - http://ar.iiarjournals.org/cgi/pmidlookup?view=long&amp;pmid=24403472 DB - PRIME DP - Unbound Medicine ER -