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Intracranial volume before and after surgical treatment for isolated metopic synostosis.
J Craniofac Surg. 2014 Jan; 25(1):262-6.JC

Abstract

Metopic synostosis results in a keel-shaped forehead, hypotelorism, and an increased interparietal width. This study aimed to measure the frontal and total intracranial volume in patients with metopic synostosis before and after surgery and to compare the effect of 2 different operation methods. All patients operated for isolated metopic synostosis between 2002 and 2008 at Sahlgrenska University Hospital who had undergone preoperative and/or postoperative computed tomographic examination (at 3 y of age) were included. The patients were grouped according to operation method: (1) forehead remodeling in combination with a bone graft or (2) forehead remodeling in combination with a spring. Sex- and age-matched controls were identified. A previously developed MATLAB computer program was used to measure the frontal and total intracranial volumes. Sixty patients and 198 controls were included. Preoperatively, the patients with metopic synostosis had significantly lower frontal volumes than those of the controls (P < 0.001) but equal total intracranial volumes. The operations redistributed the intracranial volume and resulted in an improved, frontal-total intracranial volume ratio. However, at 3 years of age, the frontal volume (P < 0.001), total intracranial volume (P ≤ 0.002), and ratio between the 2 (P < 0.001) were significantly lower in the patients than in the controls. The 2 operation methods were equally efficient in creating an improved frontal-total ratio. Surgery for metopic synostosis improves the distribution of the intracranial volume but does not result in normal total intracranial volume or frontal volume at 3 years of age.

Authors+Show Affiliations

From the Departments of *Plastic Surgery, and †Radiation Physics, Institute for Clinical Sciences, Sahlgrenska Academy, Göteborg University, Sahlgrenska University Hospital, Göteborg, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24406590

Citation

Maltese, Giovanni, et al. "Intracranial Volume Before and After Surgical Treatment for Isolated Metopic Synostosis." The Journal of Craniofacial Surgery, vol. 25, no. 1, 2014, pp. 262-6.
Maltese G, Tarnow P, Wikberg E, et al. Intracranial volume before and after surgical treatment for isolated metopic synostosis. J Craniofac Surg. 2014;25(1):262-6.
Maltese, G., Tarnow, P., Wikberg, E., Bernhardt, P., Lagerlöf, J. H., Tovetjärn, R., & Kölby, L. (2014). Intracranial volume before and after surgical treatment for isolated metopic synostosis. The Journal of Craniofacial Surgery, 25(1), 262-6. https://doi.org/10.1097/SCS.0000000000000423
Maltese G, et al. Intracranial Volume Before and After Surgical Treatment for Isolated Metopic Synostosis. J Craniofac Surg. 2014;25(1):262-6. PubMed PMID: 24406590.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intracranial volume before and after surgical treatment for isolated metopic synostosis. AU - Maltese,Giovanni, AU - Tarnow,Peter, AU - Wikberg,Emma, AU - Bernhardt,Peter, AU - Lagerlöf,Jakob Heydorn, AU - Tovetjärn,Robert, AU - Kölby,Lars, PY - 2014/1/11/entrez PY - 2014/1/11/pubmed PY - 2015/6/25/medline SP - 262 EP - 6 JF - The Journal of craniofacial surgery JO - J Craniofac Surg VL - 25 IS - 1 N2 - Metopic synostosis results in a keel-shaped forehead, hypotelorism, and an increased interparietal width. This study aimed to measure the frontal and total intracranial volume in patients with metopic synostosis before and after surgery and to compare the effect of 2 different operation methods. All patients operated for isolated metopic synostosis between 2002 and 2008 at Sahlgrenska University Hospital who had undergone preoperative and/or postoperative computed tomographic examination (at 3 y of age) were included. The patients were grouped according to operation method: (1) forehead remodeling in combination with a bone graft or (2) forehead remodeling in combination with a spring. Sex- and age-matched controls were identified. A previously developed MATLAB computer program was used to measure the frontal and total intracranial volumes. Sixty patients and 198 controls were included. Preoperatively, the patients with metopic synostosis had significantly lower frontal volumes than those of the controls (P < 0.001) but equal total intracranial volumes. The operations redistributed the intracranial volume and resulted in an improved, frontal-total intracranial volume ratio. However, at 3 years of age, the frontal volume (P < 0.001), total intracranial volume (P ≤ 0.002), and ratio between the 2 (P < 0.001) were significantly lower in the patients than in the controls. The 2 operation methods were equally efficient in creating an improved frontal-total ratio. Surgery for metopic synostosis improves the distribution of the intracranial volume but does not result in normal total intracranial volume or frontal volume at 3 years of age. SN - 1536-3732 UR - https://www.unboundmedicine.com/medline/citation/24406590/Intracranial_volume_before_and_after_surgical_treatment_for_isolated_metopic_synostosis_ DB - PRIME DP - Unbound Medicine ER -